Universal energy scaling law for optimally excited nonlinear oscillators.

We compute the optimal temporal profile for an external driving force F(t) that can maximize the energy absorption of any driven nonlinear oscillator. The technique is based on constraining the maximum amplitude of the force field such that optimal control theory can provide quasianalytical solutions. We illustrate this computational technique for the undamped Duffing oscillator as well as for a driven quantum mechanical two-level system. We find that under optimal force conditions the asymptotic time-dependence of the maximum amplitude growth is given by a power law X(t)∼t^{2/α}, where the (possibly noninteger) exponent is determined by the highest degree of the oscillator's nonlinearity α. As a universal result, this predicts that the maximal energy absorption of any nonlinear oscillator grows (under an optimized force field) quadratically in time. We also find for the two-level system that-even under optimized excitation conditions-the maximally achievable inversion does not monotonically increase with the force amplitude. It is characterized by an interesting sequence of n-cycle thresholds as well as a self-termination of the growth.

"Puss caterpillar" envenomation: a report from North Carolina.

A 41-year-old white man with no specific past medical history presented to the Emergency Department on October 13, 1997, following what he described as a "caterpillar bite." The insect was subsequently identified as a "puss caterpillar" (Megalopyge opercularis). The patient experienced immediate excruciating pain that radiated throughout his left arm and gradually spread to the left chest area. He presented to a nearby emergency department several hours later and received treatment. The patient was subsequently admitted for observation and released several days later. Viewed in the context of previous clinical reports, this case highlights the broad range of clinical symptoms that can result from the puss caterpillar sting.

Egg hatching activity of trihydroxylated eicosanoids in the barnacle Balanus balanoides.

Previous work has shown that eicosanoid hatching factors can be isolated from tissues of a variety of barnacle species. To further investigate the nature of barnacle hatching factor an eicosanoid fraction isolated from homogenates of the barnacle Balanus balanoides was purified on RP-HPLC and trihydroxy fatty acid fractions were bioassayed for hatching activity and analysed by GC-MS. The identified eicosanoids were 8,11,12-trihydroxy-5,9,14-eicosatrienoic acid, 8,11,12-trihydroxy-5,9,14,17-eicosatetraenoic acid, 10,11,12-trihydroxy-5,8,14,17-eicosatetraenoic acid and 10,13, 14-trihydroxy-4,7,11,16,19-docosapentaenoic acid. These studies suggest that barnacles possess a potent n-9 lipoxygenase which can metabolise either arachidonic acid, eicosapentaenoic acid or docosahexaenoic acid. The predominant eicosanoids common to all active fractions were either 8,11,12-trihydroxyeicosatrienoic acid or an isomer of 8,11-12-trihydroxyeicosatetraenoic acid, which suggests that a particular configuration of an 8,11,12 triol is barnacle hatching factor.

Identification and egg hatching activity of monohydroxy fatty acid eicosanoids in the barnacle Balanus balanoides.

Monohydroxy fatty acids (MHFAs) were isolated from homogenates of the barnacle Balanus balanoides and identified by gas chromatography-mass spectrometry (GC-MS) as 14- and 17-hydroxy docosahexaenoic acids, 8-, 11-, 12-, 15- and 18-hydroxy eicosapentaenoic acids, 13- and 16-hydroxyoctadecatrienoic acids and 9-, 13- and 15-hydroxyoctadecadienoic acids. Each monohydroxy fatty acid was tested for egg hatching activity in a bioassay using Elminius modestus egg masses, but 8-hydroxy-5, 9, 11, 14, 17-eicosapentaenoic acid (8-HEPE) was the only MHFA with barnacle egg hatching activity. Studies on the egg hatching activity of MHFAs prepared from the oxidation of polyunsaturated fatty acids showed that activity was confined to the 8-hydroxy isomer of eicosapentaenoic acid and arachidonic acid, and that unsaturation at C5 and C14, but not C17, was essential for activity. In addition, the 8(R) conformation is necessary for activity, as 8(R)-HEPE caused egg hatching at 10(-7) M whereas the enantiomer 8(S)-HEPE was inactive.

Identification of novel hydroxy fatty acids in the barnacle Balanus balanoides.

The ability of the barnacle Balanus balanoides tissues to produce eicosanoid hatching factors from endogenous polyunsaturated fatty acids has been investigated. GC-MS analysis of an active HPLC fraction from the trihydroxy fatty acid band on TLC revealed the presence of a number of trihydroxy fatty acids and two compounds which were tentatively identified as chlorinated dihydroxy fatty acids. The identified trihydroxy fatty acids are 10,11,12-trihydroxy-5,8,14-eicosatrienoic acid, 10,11,12-trihydroxy-5,8,14,17-eicosatetraenoic acid, 13,14,15-trihydroxy-5,8,11,17-eicosatetraenoic acid and 12,13,14-trihydroxy-4,7,10,16,19-docosapentaenoic acid. The tentatively identified chlorinated dihydroxy fatty acids are 9-chloro- and/or 11-chloro-8,12-dihydroxyeicosatetraenoic acid. The formation of these compounds is evidence of lipoxygenase activities in Balanus balanoides and their identification will facilitate the understanding of the roles eicosanoids play in barnacle physiology, especially with regard to the larval hatching process.

Revascularization without embolization: coronary bypass in the presence of a calcified aorta.

The densely calcified ascending aorta presents a formidable challenge to the cardiac surgeon. Clamping such an aorta in the patient requiring myocardial revascularization may result in catastrophic cerebral embolism and mar an otherwise successful surgical outcome. Myocardial revascularization using ventricular fibrillation and hypothermia without aortic cross-clamping in 3 patients with severely calcified aortas is described.

Identification of the hatching factor of the barnacle Balanus balanoides as the novel eicosanoid 10,11,12-trihydroxy-5,8,14,17-eicosatetraenoic acid.

Barnacle egg hatching factor which is released into the mantle cavity where the egg masses are brooded and stimulates embryonic musculature resulting in hatching and liberation of the larvae into the sea has been isolated in a purified form from a common barnacle Balanus balanoides. Derivatised hatching factor has been analysed by GC-MS and identified as 10,11,12-trihydroxy-5,8,14,12-eicosatetraenoic acid, a novel eicosanoid probably formed from endogenous eicosapentaenoic acid (20:5w3). Hatching factor activity is the first specific physiological function to be established for this type of compound.

Left heart decompression via the pulmonary artery.

A technique of left heart decompression is presented which is simple and easy to apply. Cannulation of the main pulmonary artery with a coiled wire reinforced venous cannula provides access for continuous suction and effectively decompresses both the left and right sides of the heart. An in-line vacuum release valve controls the amount of suction.

The adenosine triphosphatase and calcium ion-transporting activities of the sarcoplasmic reticulum of developing musce.

1. The ATPase (adenosine triphosphatase) specific activity and the total nitrogen content of the myofibrillar fraction per g. wet weight of rabbit longissimus dorsi muscle increased steadily during the late foetal stages and the first few weeks after birth. 2. The ATPase specific activity of the sarcoplasmic-reticular fraction isolated by a sucrose-density-gradient procedure rose to a sharp peak 8-10 days after birth and then declined to the adult value, which was about 25% of the maximum. 3. The peak in ATPase activity was a feature of the sarcoplasmic reticulum isolated from muscle, and the time at which it occurred in relation to birth was related to the degree of development and the activity pattern of the muscle. 4. The peak in ATPase activity of the sarcoplasmic reticulum occurred at an earlier age if newborn animals were made to exercise earlier than was normal. 5. The ;extra' ATPase associated with the sarcoplasmic reticulum and the ability to concentrate Ca(2+) increased in a similar manner over the period of development studied. 6. It is postulated that the Ca(2+)-transport system of the sarcoplasmic reticulum consists of two components, namely the ATPase and the system coupling this enzyme to Ca(2+) transport. During development the ATPase develops first and has almost reached maximum activity in the longissimus dorsi muscle of the rabbit after 8-10 days. Subsequently the activity of the coupling system rises rapidly, leading to an increase in the capacity and efficiency of Ca(2+) transport.