Moving Morehouse School of Medicine Translation Tx Research through MDTTs-Multidisciplinary Translational Teams.

Morehouse School of Medicine (SOM) works to achieve its vision of advancing health equity through conducting transformational, translation science (Tx). Tx describes our translational research continuum, symbolizing a method and scientific philosophy that intentionally promotes and supports convergence of interdisciplinary approaches and scientists to stimulate exponential advances for the health of diverse communities. Morehouse SOM actualizes Tx through multidisciplinary translational teams (MDTTs). We chronicle the identification of MDTTs by documenting formation, composition, functioning, successes, failures, and sustainability. Data and information were collected through key informant interviews, review of research documents, workshops, and community events. Our scan identified 16 teams that meet our Morehouse SOM definition of an MDTT. These team science workgroups cross basic science, clinical, and public health academic departments, and include community partners and student learners. We present four MDTTs, in various stages of progress, at Morehouse SOM and how they are advancing translational research.

Substance Use Correlates of Depression among African American Male Inmates.

Substance use correlates of depressive symptoms among incarcerated adult male African American substance users were examined in the current study. Frequency of drug use was assessed with 12 items specific to an individual's substance use. The Patient Depression Questionnaire (PHQ-9) was used to assess symptoms of depression. Approximately 90% of the sample displayed symptoms of depression ranging from minimal to severe. Regression models revealed that three substance use variables demonstrated a significant predictor of depression, including alcohol (ß = .16, p= .03), hallucinogens (ß =-.17, p =.021), and ecstasy (ß =-.14, p= .05). The study findings indicate a need to consider the role of specific substances with regard to symptoms of depression. The results are discussed in the context of transition planning for jail inmates.

Correlates of African American female adolescent offenders 3, 4-Methylenedioxymethamphetamine (MDMA or "Ecstasy") use and sexually transmitted infection morbidity.

The current study was designed to determine the extent to which self-reported ecstasy use in a population of juvenile adolescent detainees in a southern state is associated with high-risk health behaviors pertaining to sexually transmitted infection (STI) symptomology and past history of STI occurrence. Participants were 764 African American females extracted from an overall sample of 2,260 juvenile offenders housed at selected Youth Development Campuses in the state of Georgia. Significance tests were conducted using univariate logistic regressions to examine the independent associations of participant's self-reported ecstasy use and dichotomized HIV risk behavior correlates and history of having a prior STI before the most recent incarceration Participants who reported ecstasy use prior to incarceration were 1.7 (OR = 1.68, 95% CI = 0.78-3.64) and 1.8 times (OR = 1.87, 95% CI = 1.24-2.81) more likely respectively to indicate having had genital warts or chlamydia, and were more than 1.5 times (OR = 2.21, 95% CI = 0.83-5.44) and two times more likely to report having had gonorrhea or herpes, accordingly. Prevention programs for adolescent offender populations should develop interventions that target adolescents' substance use behavior as a function of STI risk taking as well as being culturally competent to deal specifically with these problem behaviors.

Self-reported ecstasy (MDMA) use and past occurrence of sexually transmitted infections (STIs) in a cohort juvenile detainees in the USA.

The current study was designed to determine the extent to which self-reported ecstasy use in a population of juvenile adolescent detainees in a southern state is associated with high-risk health behaviors pertaining to sexually transmitted infection (STI) symptomology and past history of STI occurrence. Participants were 2,260 juvenile offenders housed at selected Youth Development Campuses in the state of Georgia. Adjusted odds ratios (ORs) with 95 % confidence intervals (CIs) are presented. Juveniles who reported having used ecstasy previously were more likely to report that they had sore bumps of blisters near their sex organs before (OR 1.28, 95 % CI 0.74-2.21), with males who had used ecstasy prior incarceration being more than two times more likely to indicated that they had experienced having a drip or drainage from the penis (OR 1.76, 95 % CI 0.72-4.32), having vaginal discharge or odor from their vagina (OR 2.33, 95 % CI 1.16-4.65).

A comprehensive examination of the health knowledge, attitudes and behaviors of students attending historically black colleges and universities.

There is limited information about African American students attending Historically Black Colleges and Universities (HBCUs) in the areas of health behavior, health knowledge, and attitudes. To fill this gap, a comprehensive examination offirst-year students was undertaken at a consortium of HBCUs. A non-random sample of 1115 freshmen were administered a survey that assessed several domains including: (1) demographics, (2) general health, (3) smoking habits, (4) disease risk, (5) weight perception, (6) physical activity, (7) perceived stress, (8) eating habits, (9) social support, (10) personal/family medical history, (11) leadership, (12) domestic violence, (13) substance use, and (14) sexual behavior. In general, most students knew about health behaviors and disease risk. Areas that warrant further exploration include physical activity, sexual behavior, and drug use. The analyses provide key information for health education and prevention.

Alcohol, marijuana, and perceptions of influence on social and sexual behavior among African American adolescent female detainees.

Juvenile detainees comprise a population that engages in high-risk behavior. This study examined sexual risk and substance use behavior and the perceptions of African American female adolescent detainees (N = 765) regarding the influence of alcohol and marijuana use on their social and sexual behaviors. Overall, 58% and 64% reported alcohol and marijuana use, respectively. Alcohol's perceived influence on sexual behavior (p < .001) was significantly different between those who drank and those who did not; marijuana's influence on social (p < .01) and sexual (p < .001) behavior was significantly different between those who used marijuana and those who did not. There is a need for further study of the influence of substance use on social and sexual behavior among African American female adolescent detainees.