Vascular conductance is reduced after menthol or cold application.

OBJECTIVE: To compare the effects of commercially sold menthol (3.5%) ointment and cold application on blood flow in the forearm. DESIGN: : Prospective counterbalanced design. SETTING: University research laboratory. PARTICIPANTS: Twelve (6 men and 6 women) college-aged students. INTERVENTIONS: Each participant had blood flow measured in the brachial artery for 5 minutes before and 10 minutes after menthol ointment or cold application to the forearm. MAIN OUTCOME MEASURES: Blood velocity, arterial diameter size, and blood pressure were recorded during testing procedures. Vascular conductance was calculated based on these measures and used to describe limb blood flow. RESULTS: We observed a significant reduction (35%; P = 0.004) in vascular conductance within 60 seconds of menthol and cold application to the forearm. Vascular conductance remained significantly reduced for 10 minutes by approximately 19% after both menthol and cold application [F(2.313, 43.594) = 10.328, P < 0.0001]. There was no significant difference between conditions [F(1, 19) = 0.000, P = 0.945]. CONCLUSIONS: The application of a 3.5% menthol ointment significantly reduces conductance in the brachial artery within 60 seconds of application, and this effect is maintained for at least 10 minutes after application. The overall decline in conductance is similar between menthol ointment and cold application.

Effects of handgrip training with venous restriction on brachial artery vasodilation.

UNLABELLED: Previous studies have shown that resistance training with restricted venous blood flow (Kaatsu) results in significant strength gains and muscle hypertrophy. However, few studies have examined the concurrent vascular responses following restrictive venous blood flow training protocols. PURPOSE: The purpose of this study was to examine the effects of 4 wk of handgrip exercise training, with and without venous restriction, on handgrip strength and brachial artery flow-mediated dilation (BAFMD). METHODS: Twelve participants (mean +/- SD: age = 22 +/- 1 yr, men = 5, women = 7) completed 4 wk of bilateral handgrip exercise training (duration = 20 min, intensity = 60% of the maximum voluntary contraction, cadence = 15 grips per minute, frequency = three sessions per week). During each session, venous blood flow was restricted in one arm (experimental (EXP) arm) using a pneumatic cuff placed 4 cm proximal to the antecubital fossa and inflated to 80 mm Hg for the duration of each exercise session. The EXP and the control (CON) arms were randomly selected. Handgrip strength was measured using a hydraulic hand dynamometer. Brachial diameters and blood velocity profiles were assessed, using Doppler ultrasonography, before and after 5 min of forearm occlusion (200 mm Hg) before and at the end of the 4-wk exercise. RESULTS: After exercise training, handgrip strength increased 8.32% (P = 0.05) in the CON arm and 16.17% (P = 0.05) in the EXP arm. BAFMD increased 24.19% (P = 0.0001) in the CON arm and decreased 30.36% (P = 0.0001) in the EXP arm. CONCLUSIONS: The data indicate handgrip training combined with venous restriction results in superior strength gains but reduced BAFMD compared with the nonrestricted arm.