Assessing functional recovery following total knee replacement surgery using objective classification of level gait data and patient-reported outcome measures.

BACKGROUND: Patient recovery can be quantified objectively, via gait analysis, or subjectively, using patient reported outcome measures. Association between these measures would explain the level of disability reported in patient reported outcome measures and could assist with therapeutic decisions. METHODS: Total knee replacement outcome was assessed using objective classification and patient-reported outcome measures (Knee Outcome Survey and Oxford Knee Scores). A classifier was trained to distinguish between healthy and osteoarthritic characteristics using knee kinematics, ground reaction force and temporal gait data, combined with anthropometric data from 32 healthy and 32 osteoarthritis knees. For the osteoarthritic cohort, classification of 20 subjects quantified changes at up to 3 timepoints post-surgery. FINDINGS: Osteoarthritic classification was reduced for 17 subjects when comparing pre- to post-operative assessments, however only 6 participants achieved non-pathological classification and only 4 of these were classified as non-pathological at 12 months. In 15 cases, the level of osteoarthritic classification did not decrease between every post-operative assessment. For an individual's recovery, classification outputs correlated (r > 0.5) with knee outcome survey for 75% of patients and oxford knee score for 78% of patients (based on 20 and 9 subjects respectively). Classifier outputs from all visits of the combined total knee replacement sample correlated moderately with knee outcome survey (r > 0.4) and strongly with oxford knee score (r > 0.6). INTERPRETATION: Biomechanical deficits existed in most subjects despite improvements in Patient Reported Outcome Measures, with larger changes reported subjectively as compared to measured objectively. Objective Classification provides additional insight alongside Patient Reported Outcomes when reporting recovered outcomes.

Correlations between patient-perceived outcome and objectively-measured biomechanical change following Total Knee Replacement.

BACKGROUND: Total Knee Replacement (TKR) surgery is being utilised in a younger, more active population with greater functional expectations. Understanding whether patient-perceived measures of function reflect objective biomechanical measures is critical in understanding whether functional limitations can be adequately captured within a clinical setting. RESEARCH QUESTION: Do changes in objective gait biomechanics measures reflect patient-reported outcome measures at approximately 12 months following TKR surgery? METHODS: Three-dimensional gait analysis was performed on 41 patients with OA who were scheduled for TKR surgery, 22 of which have returned for a (9-24 month) follow-up assessment. Principal Component Analysis was used to define features of variation between OA subjects and an additional 31 non-pathological control subjects. These were used to train the Cardiff Classifier, an objective classification technique, and subsequently quantify changes following TKR surgery. Patient-perceived changes were also assessed using the Oxford Knee Score (OKS), Knee Outcome Survey (KOS), and Pain Audit Collection System scores (PACS). Pearson and Spearman correlation coefficients were calculated to establish the relationship between changes in objectively-measured and perceived outcome. RESULTS: Objective measures of biomechanical change were strongly correlated to changes in OKS(r=-0.695, p < 0.001) and KOS(r=-.810, p < 0.001) assessed outcomes. Pain (PACS) was only related to biomechanical function post-operatively (r=-.623, p = 0.003). SIGNIFICANCE: In this biomechanics study, the relationship between changes in objective function and patient-reported measures pre to post TKR surgery is stronger than in studies which did not include biomechanics metrics. Quality of movement may hold more significance for a patient's perception of improvement than functional measures which consider only the time taken or distance travelled during functional activities.

Abnormal loading and functional deficits are present in both limbs before and after unilateral knee arthroplasty.

Unilateral knee replacement is often followed by a contralateral replacement in time and the biomechanics of the other knee before and after knee replacement remains poorly understood. The aim of this paper is to distinguish the features of arthritic gait in the affected and unaffected legs relative to a normal population and to assess the objective recovery of gait function post-operatively, with the aim of defining patients at risk of poor post-operative function. Twenty patients with severe knee OA but no pain or deformity in any other lower limb joint were compared to twenty healthy subjects of the same age. Gait analysis was performed and quadriceps and hamstrings co-contraction was measured. Fifteen subjects returned 1year following knee arthroplasty. Moments and impulses were calculated, principal component analysis was used to analyse the waveforms and a classification technique (the Cardiff Classifier) was used to select the most discriminant data and define functional performance. Comparing pre-operative function to healthy function, classification accuracies for the affected and unaffected knees were 95% and 92.5% respectively. Post-operatively, the affected limb returned to the normal half of the classifier in 8 patients, and 7 of those patients returned to normal function in the unaffected limb. Recovery of normal gait could be correctly predicted 13 out of 15 times at the affected knee, and 12 out of 15 times at the unaffected knee based on pre-operative gait function. Focused rehabilitation prior to surgery may be beneficial to optimise outcomes and protect the other joints following knee arthroplasty.

The application of NCaRBS to the Trendelenburg test and total hip arthroplasty outcome.

This paper compares the frontal plane hip function of subject's known to have had hip arthroplasty via either the lateral (LA) or posterior (PA) surgical approaches and a group of subjects associated with no pathology (NP). This is investigated through the Trendelenburg test using 3D motion analysis and classification. Here, a recent development on the Classification and Ranking Belief Simplex (CaRBS) technique, able to undertake n-state classification, so termed NCaRBS is employed. The relationship between post-operative hip function measured during a Trendelenburg Test using three patient characteristics (pelvic obliquity, frontal plane hip moment and frontal plane hip power) of LA, PA and NP subjects are modelled together. Using these characteristics, the classification accuracy was 93.75% for NP, 57.14% for LA, 38.46% for PA. There was a clear distinction between NP and post-surgical function. 3/6 LA subjects and 6/8 PA subjects were misclassified as having NP function, implying that greater function is restored following the PA to surgery. NCaRBS achieved a higher accuracy (65.116%) than through a linear discriminant analysis (48.837%). A Neural Network with two-nodes achieved the same accuracy (65.116%) and as expected was further improved with three-nodes (69.767%). A valuable benefit to the employment of the NCaRBS technique is the graphical exposition of the contribution of patient characteristics to the classification analysis.

The effect of osteoarthritis of the knee on the biomechanics of other joints in the lower limbs.

The aim of this study was to examine the loading of the other joints of the lower limb in patients with unilateral osteoarthritis (OA) of the knee. We recruited 20 patients with no other symptoms or deformity in the lower limbs from a consecutive cohort of patients awaiting knee replacement. Gait analysis and electromyographic recordings were performed to determine moments at both knees and hips, and contraction patterns in the medial and lateral quadriceps and hamstrings bilaterally. The speed of gait was reduced in the group with OA compared with the controls, but there were only minor differences in stance times between the limbs. Patients with OA of the knee had significant increases in adduction moment impulse at both knees and the contralateral hip (adjusted p-values: affected knee: p < 0.01, unaffected knee p = 0.048, contralateral hip p = 0.03), and significantly increased muscular co-contraction bilaterally compared with controls (all comparisons for co-contraction, p < 0.01). The other major weight-bearing joints are at risk from abnormal biomechanics in patients with unilateral OA of the knee.

A CaRBS analysis of hip replacement approaches and non-pathology.

This study investigates the differences in hip biomechanics for subjects following a total hip arthroplasty (THA), through the lateral approach (LA) and posterior approach (PA), to those with no pathology (NP). The principal component analysis was performed on two kinematic and two kinetic waveforms (subject-based characteristics) from level gait to identify salient portions of the waveforms for comparison between the subject cohorts. These were classified to identify the differences between post-THA and non-pathological cohorts. The primary technique exposited in the THA analysis is classification and ranking belief simplex (CaRBS). Within the analysis, from the configuration of a CaRBS model, there is discussion on the model fit and contribution of the subject-based characteristics. Where appropriate, comparisons to the CaRBS model are made with the results from a logistic regression (LR) analysis. In terms of model fit, using CaRBS, 24 out of 27 LA/PA subjects (88.89%) and 13 out of 16 NP subjects (81.25%) were correctly classified as exhibiting either post-THA or NP hip functional characteristics during level gait, combining to 86.05% classification accuracy, compared with 81.40% classification accuracy when using LR.

Motion analysis of the glenohumeral joint during activities of daily living.

The shoulder complex has a larger range of motion (ROM) than any other joint complex in the human body, leaving it prone to numerous injuries. Objective kinematic analysis could yield useful functional insights that may assist clinical practice. Non-invasive optoelectronic motion analysis techniques have been used to assess the shoulders of five healthy subjects performing ROM tasks and 10 functional tasks of daily living. The four most demanding tasks - touching the side and back of the head, brushing the opposite side of the head, lifting an object to shoulder height and lifting an object to head height, required 78%, 60%, 61% and 71%, respectively, of the glenohumeral elevation necessary for full abduction in the scapular plane for the 10 shoulders. This has implications for clinical practice where maximum arm elevation is commonly used to determine a patient's ability to return to work and other everyday activities.

Does the choice of stair gait cycle affect resulting knee joint kinematics and moments?

Stair gait is a useful activity for the assessment of knee function. The aim of this study was to determine whether knee joint kinematics and moments are affected by the choice of stair gait cycle (SGC) and the step used to measure ground reaction forces (GRFs). This was investigated through motion analysis of ten non-pathological subjects as they ascended and descended a four-step staircase. The SGCs compared for ascent were, first, step 1 (measuring GRFs) to step 3 and, second, step 2 (measuring GRFs) to step 4, and vice versa for stair descent. Knee joint kinematics were not significantly influenced by the choice of SGC. For ascent, significantly larger peak adduction moments were measured for SGCs beginning on step 1 (0.30 +/- 0.08 N m/kg) than for SGCs beginning on step 2 (0.23 +/- 0.09 N m/kg). For descent, the second flexion moment peak was found to be significantly larger for SGCs ending on step 2 (1.17 +/- 0.25 N m/kg) than for SGCs ending on step 1 (0.97 +/- 0.19 N m/kg), and the first adduction moment peak was found to be significantly larger for SGCs ending on step 2 (0.28 +/- 0.15 N m/kg) than for SGCs ending on step 1 (0.21 +/- 0.18 N m/kg). This study highlights important considerations when planning stair gait measurement protocols and comparing results from studies made by other laboratories.

Challenges facing quantification of rat locomotion along beams of varying widths.

Optoelectronic motion capture systems have been widely used to investigate temporal gait parameters in humans and animals in order to understand function and behavioural attributes of different pathologies, e.g. Parkinson's disease (PD). The aim of the present paper was to investigate the practicality of utilising this system to investigate the effects of a unilateral 6-hydroxydopamine (6-OHDA) lesion on rat locomotion while walking on beams of varying widths (graduated, narrow, and wide). Temporal gait parameters of ten male Lister Hooded rats (five controls and five hemiparkinsonian) were observed using passive markers placed in locations that were representative of their four limbs and their body axis. The results demonstrate that marker-based motion capture can provide an effective and simple approach to quantifying temporal gait parameters for rat models of PD. They also reveal how the width of the path affects the locomotion in both experimental cohorts. Such measurements can be compared with human motion analysis to explore correlations between the animal model and human behaviour, which is an important step for translational medicine.

Introducing a new staircase design to quantify healthy knee function during stair ascent and descent.

The design, manufacture and validation of a new free standing staircase for motion analysis measurements are described in this paper. The errors in vertical force measurements introduced when the stairs interface with a force plate (FP) are less than 0.6%. The centre of pressure error introduced is less than 0.7 mm compared to the error from the FP. The challenges of introducing stair gait into a clinical trial with a limited number of FPs and time limitations for assessment sessions are addressed by introducing this cost effective solution. The staircase was used in a study to measure non-pathological knee function of 10 subjects performing stair ascent and descent. The resulting knee kinematics and knee joint moments are in agreement with previous studies. The kinematic and joint moment profiles provide a normative range, which will be useful in future studies for identifying alterations in joint function associated with pathology and intervention.

Dynamic tracking of the scapula using skin-mounted markers.

The shoulder complex is prone to numerous pathologies and instabilities due to its large range of motion. The extent of injury is assessed through a series of observations and physical examinations. It is hypothesized that objective kinematic analysis of the shoulder could yield useful functional insights to aid clinical practice. Non-invasive motion analysis techniques to monitor shoulder function have been developed using passive markers; however, accurate measurement of scapula kinematics is problematic because of overlying tissue. The scapula locator is the accepted standard by which alternative non-invasive techniques of scapula tracking are validated. In this study, the viability of using skin-mounted markers to measure dynamic scapula movement is determined. Complete kinematic descriptions of ten healthy shoulders were obtained. Elevations of the glenohumeral joint were similar with both techniques, indicating that the skin marker method is suitable for gathering functional glenohumeral data. The main differences of note are seen at the scapulothoracic articulation where the skin marker method underestimated lateral rotation by more than 50 degrees at maximum elevation. However, the correlation between the two approaches is greater than 0.7, suggesting that it may be possible to derive linear regression models to predict dynamic scapulothoracic lateral rotation accurately using skin-mounted scapula markers.

Medical engineering at Cardiff University. Part 1: Undergraduate programmes of study.

Cardiff University has offered a medical engineering undergraduate programme since 2001 and hence delivers one of the longest-running and most established medical engineering programmes within the UK. It currently offers BEng (Hons) and MEng (Hons) programmes that are both accredited by the Institution of Mechanical Engineers and include the option to undertake a year in industrial employment. The admissions policy ensures that the intake consists of a diverse range of students and is typically very successful in attracting female students. The programmes consist of six key academic threads which ensure that the content is both relevant and continuous, with all threads tailored to provide a patient-focused learning environment. Students initially learn core and fundamental principles in years 1 and 2, supported by a range of laboratories and practical experimentation. The latter years then encourage the students to corroborate and apply this knowledge, including involvement in a range of project-based learning exercises. The programme is delivered by a core of experienced academic medical engineers, with support from other engineering colleagues, as well as colleagues from the School of Biosciences, the School of Medicine, and the National Health Service. Thus, the programme delivers a wide range of modules which guarantee that graduating students have a thorough understanding of all possible career options. These two factors are significant in making it possible for students to follow their chosen career path upon graduation.

Medical engineering at Cardiff University. Part 2: Postgraduate programmes of study.

The Medical Engineering team within the School of Engineering, Cardiff University, delivers two postgraduate programmes of study. Established over 10 years ago, the part-time MSc programmes in Orthopaedic Engineering and Clinical Engineering offer the opportunity of further study while remaining within full-time employment. Both programmes deliver 120 taught credits over two academic years via a series of residential weekends, with successful completion enabling the student to undertake and then defend a 60-credit research dissertation. Fulfilling a specific role on the career pathway for both student cohorts, the strength of each programme is indicated by the consistent number of applicants.

Comparing different data collection and analysis techniques for quantifying healthy knee joint function during stair ascent and descent.

There is currently no standard data collection or analysis method for the assessment of stair gait using motion analysis. This makes the comparison of results from different studies difficult. It is important to gain an appreciation of the discrepancies in kinematic and kinetic information generated by employing different computational approaches, as these differences may be critical in cases where methodologies were to change over a long-term study. This study explores the effect of using different methodologies for the assessment of non-pathological knee function of ten subjects during stair ascent and descent. Two methods of computing knee kinematics were compared: (a) using in-house software and a pointer method of anatomical calibration and (b) using commercial software, Visual3D (C-motion, Inc.) and skin-mounted markers. Significant differences were found between the two methods when calculating a frontal plane range of motion (p < 0.05). Three methods of computing knee moments were compared. Knee moments computed using the inverse dynamic analysis (IDA) approach of Visual3D (C-motion, Inc.) were significantly different (p < 0.05) to those calculated using in-house IDA software that ignores the foot and ankle and to those computed using a vector cross-product approach. This study highlights the implications of comparing data generated from different collection and analysis methods.

Objective functional assessment of total hip arthroplasty following two common surgical approaches: the posterior and direct lateral approaches.

Despite the high number of total hip arthroplasty (THA) procedures performed each year, there is no common consensus on the best surgical approach. Gait is known to improve following THA although it does not return to what is typically quantified as normal, and surgical approach is believed to be a contributing factor. The current study evaluates postoperative hip function and provides an objective assessment following two common surgical approaches: the McFarland-Osborne direct lateral and the southern posterior. Faced with the common problem of providing an objective comparison from the wealth of data collected using motion analysis techniques, the current study investigates the application of an objective classification tool to provide information on the effectiveness of each surgery and to differentiate between the characteristics of hip function following the two approaches. Seven inputs for the classifier were determined through statistical analysis of the biomechanical data. The posterior approach group exhibited greater characteristics of non-pathological gait and displayed a greater range of functional ability as compared with the lateral approach cohort. The classification tool has proved to be successful in characterizing non-pathological and THA function but was insufficient in distinguishing between the two surgical cohorts.

An objective tool for assessing the outcome of total knee replacement surgery.

The need for an objective tool to assess the outcome of total knee replacement (TKR) surgery is widely recognized. This study investigates the potential of an objective diagnostic tool for assessing the outcome of TKR surgery based on motion analysis techniques. The diagnostic tool has two main elements: collection of data using motion analysis, and the assessment of knee function using a classifier that is based around the Dempster-Shafer theory of evidence. The tool was used to analyse the knee function of nine TKR subjects preoperatively and at three stages post-operatively. Using important measurable characteristics of the knee, the tool was able to establish the level of benefit achieved by surgery and to enable a comparison of subjects. No subject recovered normal knee function following TKR surgery. This has important implications for knee implant designs.

Three-dimensional measurement of intervertebral kinematics in vitro using optical motion analysis.

Measurement of the stiffness of spinal motion segments is widely used for evaluating the stability of spinal implant constructs. A three-dimensional motion analysis technique has been developed that allows accurate measurement of the relative movement of the vertebral bodies about a well-defined anatomical axis system. The position of marker clusters on each vertebra is tracked using digital infrared cameras (Qualisys AB, Gothenburg). Landmarks are identified using a marked pointer, and an anatomical coordinate system is defined for each vertebra. The transformation relating the upper and lower vertebrae is calculated, using the joint coordinate system approach of Grood and Suntay to find the rotations and translations in each anatomical plane. The stiffness of vertebrectomy constructs was investigated using a Synex vertebral body replacement and an anterior rod with one or two screws in each vertebral body, with or without damage to the posterior longitudinal ligament (PLL). A moment of 2 N m was applied about each anatomical axis, and the range of motion about each axis was calculated. The range of motion in flexion-extension and lateral bending was significantly greater with only one screw. When the PLL was cut, there was no significant increase in the range of motion.

How accurate is partial weightbearing?

The accuracy of partial weightbearing was assessed in six healthy volunteers and 23 patients who had sustained either a fracture of a lower limb or surgery. They were trained to weightbear partially using the conventional bathroom scale method and were assessed in a gait laboratory using force platforms. The amount of weight exerted on the involved limb during three-point crutch walking was determined. Four of six volunteers exerted a mean of 27% of body weight more than required. The remaining two volunteers exerted a mean of 8.5% of body weight less than required. Of the 23 patients, 21 exerted a mean of 35.3% of body weight more than that prescribed and two patients exerted a mean of 11.97% of body weight less than that prescribed. In both groups there was little relationship between the weightbearing prescribed and actual weightbearing. None of the patients or volunteers was able to reproduce the extent of partial weightbearing for which they were trained using the bathroom scale method, confirming that this technique of instructing patients in partial weightbearing is inaccurate.

A novel approach to forensic investigation: three-dimensional kinematic and kinetic motion analysis.

Following a domestic incident, a five-year-old child was pronounced dead on arrival at hospital. The subsequent post-mortem examination found that the cause of death was peritonitis as a result of a rupture of the duodenum. During the police interview, the main suspect alleged that the injury occurred whilst playing a game which involved standing on the child's abdomen and chest. A reconstruction of the game was performed using 3-dimensional kinematic and kinetic motion analysis to investigate the feasibility of the statement as described by the defendant. Presented is a summary of the investigation together with a description of kinematic and kinetic methods employed.