ALGORITHM OF COMPLEX REHABILITATION OF PATIENTS WITH IATROGENIC OCCLUSAL DISORDERS COMBINED WITH VERTICAL MALOCCLUSION.

OBJECTIVE: The aim: To propose the algorithm of complex rehabilitation of patients with iatrogenic occlusal disorders combined with vertical malocclusion and prove its efficiency. PATIENTS AND METHODS: Materials and methods: 55 patients with iatrogenic occlusal disorders combined with vertical malocclusion aged from 23 to 47 years old (mean age 36.1±5.2 years) including 32 females and 23 males were examined at Dental Medical Center of Bogomolets National Medical University during 2019-2021 years. All patients before and 6 months after treatment underwent clinical and laboratory examination, X-ray, electromyography, T-Scan Digital Occlusal Analysis. RESULTS: Results: In all 3 groups of patients we observed complete disappearance or significant reduction of complaints and symptomatic manifestations after 6 months of complex rehabilitation. CONCLUSION: Conclusions: Our study showed that the proposed algorithm of complex rehabilitation of patients with iatrogenic occlusal disorders combined with vertical malocclusion, which provides a multidisciplinary and individualized approach, improves the efficiency of orthodontic treatment of such patients and significantly reduces the duration of treatment in all 3 groups. This sequence of diagnostic and treatment measures gives the best opportunities for the patient to achieve maximum functional and aesthetic result.

The influence of drug treatment on cardio-vascular system of the rats with congenital hypothyroidism.

OBJECTIVE: Introduction: In the treatment of hypothyroidism substitution therapy with L-thyroxine is used, it is also advisable to use the metabolites with membrane-stabilizing properties that normalize the metabolism in the body, for example, calcitonin, which significantly reduces the depth of the dystrophic phenomena in the myocardium. The aim was to study the patterns of structural changes in the left ventricular myocardial capillaries of rats with congenital hypothyroidism in combinative drug therapy with L-thyroxine and calcitonin. PATIENTS AND METHODS: Materials and methods: 30 white Wistar line rats were used as experimental animals: 10 with treatment and 10 without as well as control - 10 intact Wistar line rats of the same age. Mercazolil was used to inhibit thyroid gland in order to model congenital hypothyroidism. After birth, the rats received L-thyroxine at a dose of 10 µg / kg per os daily, calcitonin at a dose of 1.0 MU / kg per day intramuscularly, then with mother's milk, later by themselves for 100 days. The arterial pressure was measured in all experimental groups during extraction from the experiment by plethysmograph, their left ventricular myocardium was examined under electron microscope and micropinocytotic vesicles in their cells were studied morphometrically. RESULTS: Results: In rats with congenital hypothyroidism, for which L-thyroxin drug in combination with calcitonin was used as a substitution therapy, after pharmacological correction, in general there is no pronounced heteromorphism of the ultrastructure of the left ventricular myocardial blood capillaries, which was characteristic for animals without pharmacological correction. The analysis showed normalization of the content of free thyroxine in blood plasma and blood pressure of rats with congenital hypothyroidism after complex substitution therapy. CONCLUSION: Conclusions: In rats with congenital hypothyroidism, which received L-thyroxine and calcitonin at birth, the myocardium capillaries generally remain intact and have morphological and functional characteristics similar to intact animals, which is the theoretical basis for the need for calcitonin to be used in substitution therapy in hypothyroidism.