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Bioorg Khim ; 40(2): 170-7, 2014.
Article in Russian | MEDLINE | ID: mdl-25895336

ABSTRACT

Convenient two-step synthesis of conjugates of HS-CoA and D-pantetheine with aminooxy analogues of Spm, Spd and Put was suggested. The use of acetone linker provided target conjugates with quantitative yields. The activity of CoA-derived "bisubstrate" inhibitors being active at microM concentrations was at least 100 times better than that of corresponding derivatives of D-pantetheine.


Subject(s)
Acetyltransferases/chemical synthesis , Polyamines/metabolism , Spermidine/chemical synthesis , Spermine/chemical synthesis , Acetyl Coenzyme A/chemistry , Acetyltransferases/chemistry , Bacteria/chemistry , Bacteria/metabolism , Bacteria/pathogenicity , Kinetics , Pantetheine/chemistry , Polyamines/chemistry , Spermidine/chemistry , Spermine/chemistry
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