ABSTRACT
The aqueous extracts of Datura fastuosa leaves and seeds were evaluated for the analgesic effect on acetic acid-induced writhing and hot plate reaction in mice. According to the results, D. fastuosa leaves and seeds extracts at oral doses of 400 and 800 mg/kg are effective as analgesic. The analgesic activity of leaf extract is reduced by naloxone but not that of seed extract.
Subject(s)
Analgesics/pharmacology , Datura , Pain/prevention & control , Phytotherapy , Plant Extracts/pharmacology , Acetic Acid , Administration, Oral , Analgesics/administration & dosage , Analgesics/therapeutic use , Animals , Dose-Response Relationship, Drug , Hot Temperature , Mice , Pain/chemically induced , Pain Measurement/drug effects , Plant Extracts/administration & dosage , Plant Extracts/therapeutic use , Plant Leaves , SeedsABSTRACT
The essential oil of Lippia multiflora Moldenke (Verbenaceae) produced by conventional hydrodistillation was analyzed and studied for its analgesic, antipyretic and anti-inflammatory activities in rats and mice. At the doses used (2, 4 and 8 ml/kg o.s.) the essential oil of L. multiflora showed significant and dose-dependent analgesic effect on acetic acid-induced writhing in mice. Only the dose of 8 ml/kg of essential oil, antagonized hyperexia induced by brewer's yeast. No effect on granuloma formation was observed.
