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SAFB1- and SAFB2-mediated transcriptional repression: relevance to cancer.

Hong, Elaine A; Gautrey, Hannah L; Elliott, David J; Tyson-Capper, Alison J.

Biochem Soc Trans ; 40(4): 826-30, 2012 Aug.

Article in English | MEDLINE | ID: mdl-22817742

ABSTRACT

SAFB1 (scaffold attachment factor B1) and a second family member SAFB2, are multifunctional proteins implicated in a variety of cellular processes including cell growth, apoptosis and stress response. Their potential function as tumour suppressors has been proposed based on well-described roles in tran-scriptional repression. The present review summarizes the current knowledge of SAFB1 and SAFB2 proteins in transcriptional repression with relevance to cancer.

Subject(s)

Matrix Attachment Region Binding Proteins/metabolism , Neoplasms/metabolism , Animals , Humans , Matrix Attachment Region Binding Proteins/genetics , Neoplasms/genetics , Nuclear Matrix-Associated Proteins/genetics , Nuclear Matrix-Associated Proteins/metabolism , Receptors, Estrogen/genetics , Receptors, Estrogen/metabolism , Transcription, Genetic/genetics

ABSTRACT

Subject(s)

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