1.
Org Lett
; 7(20): 4507-10, 2005 Sep 29.
Article
in English
| MEDLINE
| ID: mdl-16178570
ABSTRACT
[reaction: see text] A new protocol for the sequential allylic transfer reaction of a diene with two aldehydes in the construction of cyclic systems containing four stereogenic centers is achieved in a one-pot operation. Reaction of the diene-alehyde 1 with aldehyde in the presence of the diboronyl reagent catalyzed by a nickel complex produces products 2 and 3 depending on reaction conditions in high levels of diastereoselectivity. Extension of this method to the synthesis of six-membered rings is also investigated.