Comparison of anti-plaque efficacy between a low and high cost dentifrice: A short term randomized double-blind trial.

OBJECTIVE: The aim of this study was to compare the anti-plaque efficacy of a low and high cost commercially available tooth paste among 13-20 years old adolescents in a Residential Home, Bhopal, India. MATERIALS AND METHODS: The study was randomized double-blind parallel clinical trial conducted in a Residential Home, Bhopal, India. A total of 65 patients with established dental plaque and gingivitis were randomly assigned to either low cost or high cost dentifrice group for 4 weeks. The plaque and gingival scores at baseline and post-intervention were assessed and compared. Statistical analysis was performed using paired t-test and the independent sample t-test. The statistical significance was fixed at 0.05. RESULTS: Results indicated a significant reduction in plaque and gingival scores in both groups post-intervention compared with the baseline. Difference between the groups was not significant. No adverse events were reported and both the dentifrices were well-tolerated. CONCLUSION: Low cost dentifrice is equally effective to the high cost dentifrice in reducing plaque and gingival inflammation.

Cyclin B1 overexpression in conventional oral squamous cell carcinoma and verrucous carcinoma- A correlation with clinicopathological features

Background: Nuclear localization of cyclin B1 is an indicator for cells undergoing mitotic division, and the overexpression has shown promising results as a good prognostic predictor for patients of squamous cell carcinoma (SCC). Cyclin B1 overexpression among histological grades of conventional oral squamous cell carcinoma (COSCC), as well as comparison with verrucous carcinoma (VC) has been less investigated. Study Design: Immunohistochemical expression of cyclin B1 was compared with various clinicopathological features in 30 primary COSCC and 31 primary VC cases. Result: Cyclin B1 showed significant overexpression for some clinical features for both the variants of oral squamous cell carcinoma. In histopathological variants, statistical significance was observed among grades of COSCC, as well as COSCC and its grades with VC. The concomitant increase in cyclin B1 overexpression from VC to grades COSCC was observed. Conclusion: Our study findings draw attention to cyclin B1 overexpression is involved in early carcinogenesis, cell differentiation and tumor proliferation (AU)

Cyclin B1 overexpression in conventional oral squamous cell carcinoma and verrucous carcinoma- A correlation with clinicopathological features.

BACKGROUND: Nuclear localization of cyclin B1 is an indicator for cells undergoing mitotic division, and the overexpression has shown promising results as a good prognostic predictor for patients of squamous cell carcinoma (SCC). Cyclin B1 overexpression among histological grades of conventional oral squamous cell carcinoma (COSCC), as well as comparison with verrucous carcinoma (VC) has been less investigated. STUDY DESIGN: Immunohistochemical expression of cyclin B1 was compared with various clinicopathological features in 30 primary COSCC and 31 primary VC cases. RESULT: Cyclin B1 showed significant overexpression for some clinical features for both the variants of oral squamous cell carcinoma. In histopathological variants, statistical significance was observed among grades of COSCC, as well as COSCC and its grades with VC. The concomitant increase in cyclin B1 overexpression from VC to grades COSCC was observed. CONCLUSION: Our study findings draw attention to cyclin B1 overexpression is involved in early carcinogenesis, cell differentiation and tumor proliferation.

Malocclusion and treatment needs of cleft lip and/or palate subjects aged between 12 and 18 years visiting KLE's Hospital, Belgaum, India.

PURPOSE: The aim of the present study was to investigate the malocclusion status and treatment needs of adolescents with cleft lip and/or palate aged between 12 and 18 years, and to compare them with those of non-cleft subjects. MATERIALS AND METHODS: A cross-sectional survey was conducted at the Outpatient Department, Plastic and Reconstructive Surgery, KLE's Hospital and Medical Research Centre, Belgaum, India, during the period March to September 2004. The sample comprised 56 cleft lip and/or palate subjects aged between 12 and 18 years who were matched with 168 non-cleft subjects (controls) selected from the general population. The clinical examination was conducted using methods recommended by the World Health Organization oral health surveys. The Dental Aesthetic Index (DAI) was used to record the data. RESULTS: About 37.5% of cleft lip and/or palate subjects and 60.71% of controls scored a DAI ≤ 25 (no abnormality or minor malocclusion). About 51.78% of cleft lip and/or palate subjects and approximately one-third of controls (35.71%) scored a DAI of 26 to 30 (definite malocclusion). Subjects with cleft lip and/or palate disorder (8.92%) and controls (2.97%) scored a DAI of 31 to 35 (severe malocclusion, P = 0.06). Subjects with cleft lip and/or palate disorder (1.78%) and controls (< 1%) scored a DAI ≥ 36 (handicapping malocclusion). CONCLUSIONS: A majority of the cleft lip and/or palate subjects exhibited severe malocclusion, and treatment was highly desirable when compared to non-cleft subjects.