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Objective To investigate the curative effects of fluvastatin and its anti-inflammation mechanism in early diabetic nephropathy (EDN).Methods 140 patients with EDN were randomly divided into two groups,the control group (n=70) and the treated group (n=70).The control group received conventional therapy,while the treated group was added oral 40 microgram of fluvastatin every night.Compare the UAER,Scr and CRP 3,6 and 9 months later respectively.Results UAER and Scr had been decreased more significantly and quickly(three months earlier) in treated group than in control group. CRP had been decreased significantly in treated group,while no significant decrease had been found in control group during the follow-up of nine months.Furthermore,similar results were also obtained in those EDN with normolipidemia when further analyzed.Conclusion Fluvastatin can ameliorate microalbuminuria and improve renal function by its anti-inflammation effect by decreasing CRP,which is independent of its lowering lipidemia effect.
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0.05).But in the group EDN and CDN,Lp(a) was significantly higher as compared with the former two groups (P
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Objective To study the effects of integrated liposomal prostagladin E 1(Lipo PGE 1) and fosinopril on early diabetic nephropathy (DN) and clinical DN.Methods 86 patients of type 2 diabetic patients with DN were randomly divided into control group (fosinopril) and treated group(fosinopril+Lipo PGE 1).UARE,Scr and BUN figures were compared between two groups before treatment and eight weeks after treatment.Results UAER had been decreased significantly in both groups(P0.05).Furthermore,no significant decrease of BUN、FBG、MPA、TC and TG had been found in both groups.Conclusion Integrated Lipo PGE 1and fosinopril can ameliorate proteinuria and improve renal function of the patients with early DN and clinical DN of normal renal function.
