ABSTRACT
Five forms of the drug alprazolam have been identified by thermal analysis and X-ray powder diffraction (XRD). The single crystal X-ray structures of two of these species, a polymorph 1 and a dihydrate 2, were determined. The dihydrate crystallized from a solution of alprazolam in methanol containing traces of water. Species 3 and 4 are nonstoichiometric solvates with ethanol and acetonitrile, respectively. The differential scanning calorimetric curves for the solvates 2-4 are similar, showing a desolvation endotherm, followed by an exotherm associated with recrystallization, and a final endotherm for the fusion of alprazolam. The solvates 3 and 4 were shown to be isomorphous by XRD. The products of desolvation of 2-4 were identified by their XRD traces. Solvates 2 and 3 yield polymorph 1 on desolvation, whereas solvate 4 yields a different polymorph.
Subject(s)
Alprazolam/chemistry , Calorimetry, Differential Scanning , Crystallization , Crystallography, X-Ray , Isomerism , Solubility , Solvents , Thermodynamics , ThermogravimetryABSTRACT
A case of Kallmann's syndrome (hypogonadotrophic eunochoidism plus anosmia) in which further investigation revealed the association of unilateral renal agenesis is described. The importance of excretory urography in the investigation of patients with Kallmann's syndrome is stressed.
