A Comparision of Hemodynamic Changes of Total Intravenous Anesthesia (TIVA) and Isoflurane for Tonsillectomy in Children / 대한마취과학회지

BACKGROUND: In anesthesia for tonsillectomy in children, deep general anesthesia, rapid recovery to consciousness and the return of protective airway reflexes are desirable. This study was designed to estimate the efficacy of TIVA with propofol and fentanyl compared with isoflurane-N2O. METHODS: Forty pediatric patients in ASA class I for tonsillectomy were allocated randomly to either TIVA with propofol and fentanyl (n=20, T) or isoflurane-N2O (n=20, I) group. Anesthesia was induced with propofol 1 mg/kg, fentanyl 3 microgram/kg IV and was maintained by continuous infusion of propofol 6~10 mg/kg/hr, fentanyl 6~10 microgram/kg/hr in T group and was induced with thiopental 5 mg/kg IV and maintained by inhalation of 1.2~2.5 vol% isoflurane in I group. The changes of hemodynamics, recovery time and complications were evaluated. RESULTS: Systolic and diastolic pressure were increased in I group than T group at 1 min after intubation (p<0.05). Heart rate was increased in I group than T group at 1 min after intubation, 1 min and 5 min after incision, changing tube, end of operation and 5 min after end of operation (p<0.05). The recovery time was shorter in T group than I group (p<0.05). Pain on injection was more frequent in T group than I group (p<0.05), and excitatory effect during emergence was more frequent in I group than T group (p<0.05). CONCLUSIONS: TIVA with fentanyl and propofol is better than isoflurane-N2O for anesthesia of tonsillectomy in children in view of small hemodynamic change, early and gentle recovery pattern and side effects.

The Effect of Anesthesia with Propofol-N2O on Neonate and Maternal Awareness during Cesarean Section / 대한마취과학회지

BACKGROUND: In anesthesia for cesarean section, there is an increased incidence of maternal awareness because a light plane of general anesthesia is chosen for fetal safety and rapid recovery. Propofol may be the choice if smooth induction and rapid maternal recovery are desired. Authors tried to know that propofol has properties which suggest that it might be useful alternative to thiopental and enflurane. METHODS: Forty patients in ASA class I or II scheduled for cesarean section were allocated randomly to either propofol (n=20) (P) or thiopental-enflurane (n=20) (T-E) group. Anesthesia was induced with propofol 2 mg/kg IV and maintained by continuous infusion of propofol 8 mg/kg/hr in P group and was induced with thiopental 4 mg/kg IV and maintained by inhalation of 1 vol% enflurane in T-E group. All patients received vecuronium 0.1 mg/kg and 50% N2O-O2. Blood pressure, heart rate, Apgar score, umbilical arterial blood gas analysis and the incidence of maternal awareness using the isolated forearm technique (IFT) were evaluated. RESULTS: Diastolic pressure was decreased in P group than T-E group at 10 min after delivery. Heart rate was increased in P group than T-E group at immediate after extubation (p<0.05). For apgar score, umbilical artery gas analysis and maternal awareness there were not significant differences between two groups. CONCLUSIONS: In comparison with thiopental-enflurane, propofol infusion (8 mg/kg/hr) coupled with N2O was proved to be clinically satisfactory anesthesia for cesarean section with no adverse effects on both mother and neonate.

Cardiovascular Response of Esmolol and Diltiazem to Endotracheal Extubation / 대한마취과학회지

BACKGROUND: Tracheal extubation causes hypertension and tachycardia. In susceptable patients, even this short period of hypertension and tachycardia can result in myocardial ischemia. The purpose of this study was to evaluate the effect of esmolol and diltiazem in attenuating cardiovascular responses to tracheal extubation. METHODS: Changes in heart rate, systolic and diastolic blood pressure were measured during extubation and emergence from anesthesia in 60 ASA physical status I patients to assess the effect of esmolol and diltiazem. The patients were randomly assigned to one of three groups (n=20 for each group) : saline 5 ml (as a control), 0.2 mg/kg diltiazem and 1.5 mg/kg esmolol. These medications were given 2 min before tracheal extubation. RESULTS: Both groups of diltiazem and esmolol were greater attenuating effect on changes of heart rate, systolic and diastolic blood pressure than control group. The inhibitory effect on changes of heart rate was greater with esmolol than diltiazem, but the attenuating effect on changes of systolic blood pressure was greater with diltiazem than esmolol. CONCLUSIONS: We concluded that a bolus dose of intravenous diltiazem 0.2 mg/kg or esmolol 1.5 mg/kg given at 2 min before extubation was of value in attenuating the cardiovascular changes occuring in association with tracheal extubation and emergence from anesthesia. Esmolol is more effective than diltiazem in attenuating the heart rate changes. Diltiazem is more effective than esmolol in attenuating the systolic blood pressures changes.

Changes in Airway Pressure, Blood Gas and Postoperative Emesis of 50% N2O in Laparoscopic Cholecystectomy / 대한마취과학회지

BACKGROUND: The use of laparoscopic techniques in general surgery has gained increasing popularity. The small, limited incisions are well accepted by patients and there is the benefit of a faster recovery. But the contribution of N2O to nausea and vomiting is still controversial. This study was undertaken to evaluate the effect of N2O for airway pressure, blood gas and postoperative emesis in laparoscopic cholecystectomy. METHODS: Twenty ASA physical status I, II patients for elective laparoscopic cholecystectomy were randomly divided into two groups. First group (n=10) of patients was anesthetized with isoflurane(0.5~1.5 vol%)-O2 (2 l/min)-air (2 l/min). Second group (n=10) of patients was anesthetized with isoflurane (0.5~1.5 vol %)-O2 (2 l/min)-N2O(2 l/min). After induction of anesthesia, ventilation was controlled with tidal volume 10 ml/kg and respiratory rate 11/min and not changed throughout the operation. After measuring of control value of PaCO2, pH and airway pressures before CO2 insufflation, repeatedly measured at 20 min, 40 min after CO2 insufflation and 10 min after CO2 exsufflation. We observed the patients concerning nausea and vomiting for postoperative period. RESULTS: There were no significant intraoperative differences between the both groups with respect to PaCO2, pH and airway pressures. In the both groups, PaCO2 and airway pressure throughout the operation are significantly increased in comparison to control values. The pH is significantly decreased in comparison to control values. The incidence of postoperative nausea and vomiting was similar in both groups. CONCLUSIONS: N2O had no clinically apparent effects on airway pressure, blood gas and postoperation emesis during laparoscopic cholecystectomy.

Analgesic Effects of Epidural Bupivacaine, Alone or in Combination with Clonidine on Pain after Cesarean Section / 대한마취과학회지

Epidural clonidine produces analgesia via non-opioid mechanism and it may be used as an adju-vant to local anesthetics in obstetric analgesia. To evaluate the effects of epidural clonidine and bupivacaine for post-cesarean section analgesia, we designed a double-blind study. Sixty patients scheduled for elective cesarean section were divided into three groups. Group 1 (n=20) received 0.125% bupivacaine 2 ml/hour epidurally for 2 days. Group 2 (n=20) received 150 ug clonidine bolus, followed by 0.125% bupivacaine 2 ml/hour and clonidine 10 ug/hour for 2 days. Group 3 (n=20) received 150 ug clonidine bolus, followed by 0.125% bupivacaine 2 ml/hour and clonidine 20 ug/hour for 2 days. At the end of the cesarean section, above drug was administered epidurally. Postoperative analgesia was assessed by recording VAS(visual analogue scales) at 1, 2, 4, 8, 16, 32 and 48 postoperative hours. Sedation score, heart rate and systolic and diastolic blood pressure were also checked. The results were as follows: 1) VAS were significantly decreased in group 2 at 1~16 hours and in group 3 at 1~32 hours compared with group 1, They were decreased in group 3 compared with group 2 at 1~48 hours but no significance was seen between two groups. 2) The changes of systolic and diastolic blood pressures & sedation scores were not significantly different between any two groups. In summary, co-administration of clonidine and bupivacaine epidurally provided more profound analgesia compared with bupivacaine alone after cesarean section.

Comparison of Intra-Articular Bupivacaine and Morphine for Pain Relief after Knee Arthroscopy / 대한마취과학회지

The combination of intra-articular morphine and bupivacaine has been suggested as an ideal analgesic after arthroscopy. We performed a randomized double-blind controlled study in patients undergoing elective knee arthroscopy to investigate the analgesic effect of intra-articular morphine and bupivacaine. Sixty ASA physical status 1~2 patients were randomized into one of three treatment groups. All patients received general anesthesia with N2O, O2 and inhalational agents. The drugs were given by intra-articular injection by the surgeon before tourniquet release at the end of the operation. According to the mode of the drugs administered, the patients were divided into three groups; 1) Groupl (n=20) received 0.25% bupivacaine 2) Group2 (n=20) received morphine 1 mg in saline 3) Group3 (n=20) received morphine 1 mg in 0.25% bupivacaine. The injected volume was 25 ml, and all solutions contained 1:250,000 epinephrine. Additional postoperative analgesia was provided with intramuscular diclofenac sodium. The visual analogue pain scores in the recovery room(0.5 h) and 2, 4, 8, 12 and 24 h after surgery, time to first analgesic use, and total 24 h additional analgesic requirements were recorded. The results were as follows; 1) Visual analogue pain scores were lower in group 1 and 3 at 1~8 h. 2) Visual analogue pain scores were lower in group 2 and 3 at 24 h. 3) Additional analgesic requirements were lower for the first 12 h in group 1 and 3, but no difference was seen between groups over the 24 h study period. We conclude that, after elective knee arthroscopy, intra-articular morphine 1 mg in 0.25% bupivacaine 25 ml, with 1: 250,000 epinephine, may provide superior postoperative analgesia up to 24 h than bupivacaine or morphine alone.

A Dose-Response Effects of Oral Clonidine on Cardiovascular System and Sedative Action / 대한마취과학회지

Clonidine, an 2 agonist, has been shown to be effective as preanesthetic medication in adults. To evaluate the effects of clonidine on the sedation and cardiovascular changes induced by intubation, we administered clonidine (2.0-2.5g/kg, 4.5-5.0g/kg, peros) 90-120min before induction of anesthesia. We measured heart rate, systolic pressure and diastolic pressure before premedication, before induction, after intubation and 5, 10, 15, 20 and 30 min after intubation and evaiuated sedative sction before induction. The results are as follows: 1) Before intubation heart rate decreased significantly in both clonidine groups compared with diazepam group (P<0.05). 2) Before intubation clonidine 4.5-5.0g/kg group produced a significant reduction in systolic pressure compared with diazepam group (P<0.05). 3) After intubation systolic and diastolic blood pressure increased in all group but the increasing rate was significently less then in clonidine 4.5-5.0g/kg group (P<0.05). 4) After intubstion the increase in heart rate in both clonidine groups were significsntly less than in diazepam group (P<0.005). 5) Sedative actions were not significantly different in all groups.

A comparison of cardiovascular changes of parturient and blood - gas status of newborn umbilical cord blood according to induction agents for Caesarean section / 대한마취과학회지

In anesthesia for Caesarean section, some induction agents have been used. Thiopental so- dium is regarded as the standard induction agent. Propofol and ketamine have properties which suggest that it might be useful alternstives to thiopental. The purpose of our study was to evaluate the maternal and neonatal effect of propofol and ketamine used as induction agent for general anesthesia for elective Caeearean section. Sixty mothers undergoing elective Caesarean section under general anesthesia were allocated randomly to receive thiopental 4 mg/kg or ketamine 1 mg/kg or propofol 2 mg/ kg for induction of anesthesia. The results were as follows; 1) There were significant increase in systolic pressure, diastolic pressure and heart rate at postintubation within three groups(p<0.05). But there were no significant differences in cardiovascular responses between three groups during the induction. 2) The Apgar scores and blood gas analyses of neonates did not differ between three groups significsntly and the results were within normal range in all groups. As a result, propofol and ketamine are acceptable alternatives to thiopental for the induction of general anesthesia in Caesarean section. But in view of maternal cardiovascular changes and fetal well being, propofol and ketamine offer no significant advantage over thiopental.

Relatins of needle gauge & bevel direction for postdural puncture headache / 대한마취과학회지

Postdural puncture headache (PDPH) is probably the most common complication of spinal anesthesia. The incidence of spinal headache is believed to be related to age, sex, pregnancy, size of the dural puncture needle, direction of the needle bevel, and the angle at which the needle penetrates the dura. This study were done to see the relation of sex, age, needle size (23 gauge, 25 gauge & 27 gauge needle) & bevel direction (parallel, perpendicular insertion to the longutudinal dural fiber) on the incidence, duration, severity, and location. The following results were observed: 1) The overall incidence of headache was 7.9% (49 cases). 2) The size of the needle was statistically significant assouation of PDPH. 3) Headache occured in highest frequency in patients in the second and third decades. 4) The frequency of PDPH was inversely associated with age. 5) The onset of headache was 1-2 days (68%) and duration of headache was 4-5 days (82%) in postanesthetic day. 6) The severity of headache was mild and moderate in 90% cases.

Continuous Postoperative Regional Analgesia By Nerve Sheath Block For Limb Amputation Surgery / 대한마취과학회지

A study of continuous postoperative regional analgesia by nerve sheath block for limb amputation is presented. The authors reviewed 65 patients with amputation at the level proximal to the wrist or ankle. 15 patients of which were managed with continuous postoperative regional analgesia (CPRA) by nerve sheath block. At the time of exposure of nerve trunk during amputation, a catheter was introduced directy into the transected nerve sheath through a seperated stab wound, then infuse 0.5% bupivacaine 5ml prior to wound closure and postoperatively at the rate of 2 ml/4~6 hours for 3~4 days. The results were as follows : 1) Effective amputation stump analgesia was obtained, significantly reducing the need for narcotic analgesics. 2) 46 (70%) patients experienced Phantom phenomena and 30 (46%) patients experienced Phantom pain, a less frequently in CPRA group. 3) Phantom pain was more commonly observed in patients with rnore severe preamputation pain. 4) There were no significant relationships between the occurence of Phantom pain and the age of amputee or the level of amputation. We concluded that continuous postoperative regional analgesia by nerve sheath block significantly reduced the narcotic requirements in patients with ampotation surgeries.

Anesthetic Experience of Takayasu Arteritis Following Operation - A case report / 대한마취과학회지

Takayasu Arteritis is a systemic disease of unknown cause characterized by occlusion of the thoracic and aMominal aorta and its branches. Although it is typically a disease of young oriental women, the disease is occasionally reported in other groups. A 29-year-old pregnant woman was admitted for emergency cesarean section. Anethesia was induced with thiopental and succinylcholine and maintained with vecuronium-nitrous oxide-oxygen. After delivery, anesthesia was supplemented with fentanyl and droperidol. After delivery we couldnt detect radial arterial blood pressure in both side. Our experience would provide basic information regarding possible emergency surgery for patients with this intractable disease.

Anesthetic Experience of Takayasu Arteritis Following Operation - A case report / 대한마취과학회지

Takayasu Arteritis is a systemic disease of unknown cause characterized by occlusion of the thoracic and aMominal aorta and its branches. Although it is typically a disease of young oriental women, the disease is occasionally reported in other groups. A 29-year-old pregnant woman was admitted for emergency cesarean section. Anethesia was induced with thiopental and succinylcholine and maintained with vecuronium-nitrous oxide-oxygen. After delivery, anesthesia was supplemented with fentanyl and droperidol. After delivery we couldnt detect radial arterial blood pressure in both side. Our experience would provide basic information regarding possible emergency surgery for patients with this intractable disease.

Cardiac Arrest due to Unsuspected pheochromocytoma Presenting during Gastric Polyp Operation / 대한마취과학회지

The anesthetic management of patient with pheochromocytoma is often difficult even when a clear-cut preoperative diagnosis has been made. We experienced a patient with a gastric polyp and an unsuspected pheochromocytoma which presented with transient hypertension during general anesthesia for an elective subtotal gastrectomy. The patient developed severe hypertension and arrhythmia leading to cardiac arrest just after the skin incision. This case illustrate the value of preoperative evaluation in a patient with transient hypertension.

Blood Presure Changes and Blood Loss in General Anesthesia for Total Hip Replacement / 대한마취과학회지

31 cases of general anesthesia for total hip replacement which were performed at K.N.U. hospital from 1980 to 1982 were measured blood pressure, blood loss, hemoglobin, and hematocrit before, during, and after operation. Blood pressure were monitored right before and at 1, 3, 5 and 8 min intervals after the insertion of the acrylic cement into the acetabulum and the femur. There was a tendency to decrease in blood pressure at 3 min after the insertion of acrylic cement in to the femur. The blood loss during and duration of 36 hrs after halothane anesthesia revealed tendency to decrease compared with the enflurane and ether. Hemoglobin and hematocrit values taken on before, during, and the 1st day after operation did not show and changes.

Effects of Open Chest Surgery on Blood Gas Valnes during Volume Controlled Ventilation Anesthesia / 대한마취과학회지

This study was attempted to observe the possible effects of open chest and the decubitus position on blood gas values during controlled ventilation. We used a volume-type ventilator to maintain regular tidal volume throughout the operation. A total of 51 cases which underwent open chest surgery between 1979 and 1981 in Department of Anesthesiology in Kyungpook National University Hospital were selected. PaO2, PaCO2, pH and MAP were measured at ten minutes after induction (control group), decubitus position (ducubitus group) and chest was opened(open chest group). The PaCO2 value in open chest and decubitus group revealed a tendency of elevation compared with the control group. The PaCO2 value in open chest revealed no remarkable change compared with the control group. The pH in open chest and decubitus group showed a tendency to increase compared with the control group. The MAP showed a tendency to decrease in open chest & decubitus groups and decreased gradually. From the above results, MAP showed a gradual decrease but the increase of pH and PaO2 suggested the inclination of respiratory alkalosis due to hyperventilation during volume controlled ventilation anesthesia.