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A major locus conferring susceptibility to infection by Streptococcus pneumoniae in mice.
Denny, Paul; Hopes, Elaine; Gingles, Neill; Broman, Karl W; McPheat, William; Morten, John; Alexander, Janet; Andrew, Peter W; Brown, Steve D M.
Mamm Genome ; 14(7): 448-53, 2003 Jul.
Article in English | MEDLINE | ID: mdl-12925893

ABSTRACT

We have studied the genetics of susceptibility to infection by Streptococcus pneumoniae in mice. Linkage analysis of the F(2) generation from a cross between resistant BALB/cO1aHsd and susceptible CBA/CaO1aHsd strains allowed us to map a major locus controlling the development of bacteremia and survival after intranasal infection.


Subject(s)
Genetic Predisposition to Disease , Pneumococcal Infections/genetics , Streptococcus pneumoniae , Animals , Crosses, Genetic , Genetic Linkage , Mice , Mice, Inbred BALB C , Mice, Inbred CBA
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