Bilateral extracephalic transcranial direct current stimulation improves endurance performance in healthy individuals.

BACKGROUND: Transcranial direct current stimulation (tDCS) has been used to enhance endurance performance but its precise mechanisms and effects remain unknown. OBJECTIVE: To investigate the effect of bilateral tDCS on neuromuscular function and performance during a cycling time to task failure (TTF) test. METHODS: Twelve participants in randomized order received a placebo tDCS (SHAM) or real tDCS with two cathodes (CATHODAL) or two anodes (ANODAL) over bilateral motor cortices and the opposite electrode pair over the ipsilateral shoulders. Each session lasted 10 min and current was set at 2 mA. Neuromuscular assessment was performed before and after tDCS and was followed by a cycling time to task failure (TTF) test. Heart rate (HR), ratings of perceived exertion (RPE), leg muscle pain (PAIN) and blood lactate accumulation (ΔB[La-]) in response to the cycling TTF test were measured. RESULTS: Corticospinal excitability increased in the ANODAL condition (P < 0.001) while none of the other neuromuscular parameters showed any change. Neuromuscular parameters did not change in the SHAM and CATHODAL conditions. TTF was significantly longer in the ANODAL (P = 0.003) compared to CATHODAL and SHAM conditions (12.61 ± 4.65 min; 10.61 ± 4.34 min; 10.21 ± 3.47 min respectively), with significantly lower RPE and higher ΔB[La-] (P < 0.001). No differences between conditions were found for HR (P = 0.803) and PAIN during the cycling TTF test (P = 0.305). CONCLUSION: Our findings demonstrate that tDCS with the anode over both motor cortices using a bilateral extracephalic reference improves endurance performance.

Prolonged constant load cycling exercise is associated with reduced gross efficiency and increased muscle oxygen uptake.

This study investigated the effects of prolonged constant load cycling exercise on cycling efficiency and local muscle oxygen uptake responses. Fourteen well-trained cyclists each completed a 2-h steady-state cycling bout at 60% of their maximal minute power output to assess changes in gross cycling efficiency (GE) and muscle oxygen uptake (mVO2 ) at time points 5, 30, 60, 90, and 120 min. Near-infrared spatially resolved spectroscopy (NIRS) was used to continually monitor tissue oxygenation of the Vastus Lateralis muscle, with arterial occlusions (OCC) applied to assess mVO2 . The half-recovery time of oxygenated hemoglobin (HbO2 ) was also assessed pre and post the 2-h cycling exercise by measuring the hyperemic response following a 5-min OCC. GE significantly declined during the 2-h cycling bout (18.4 ± 1.6 to 17.4 ± 1.4%; P < 0.01). Conversely, mVO2 increased, being significantly higher after 90 and 120 min than at min 5 (+0.04 mlO2 /min/100 g; P = 0.03). The half-recovery time for HbO2 was increased comparing pre and post the 2-h cycling exercise (+7.1 ± 19s), albeit not significantly (d: 0.48; P = 0.27). This study demonstrates that GE decreases during prolonged constant load cycling exercise and provides evidence of an increased mVO2 , suggestive of progressive mitochondrial or contractile inefficiency.

Knowledge is power: Issues of measuring training and performance in cycling.

Mobile power meters provide a valid means of measuring cyclists' power output in the field. These field measurements can be performed with very good accuracy and reliability making the power meter a useful tool for monitoring and evaluating training and race demands. This review presents power meter data from a Grand Tour cyclist's training and racing and explores the inherent complications created by its stochastic nature. Simple summary methods cannot reflect a session's variable distribution of power output or indicate its likely metabolic stress. Binning power output data, into training zones for example, provides information on the detail but not the length of efforts within a session. An alternative approach is to track changes in cyclists' modelled training and racing performances. Both critical power and record power profiles have been used for monitoring training-induced changes in this manner. Due to the inadequacy of current methods, the review highlights the need for new methods to be established which quantify the effects of training loads and models their implications for performance.

Transcranial direct current stimulation improves isometric time to exhaustion of the knee extensors.

Transcranial direct current stimulation (tDCS) can increase cortical excitability of a targeted brain area, which may affect endurance exercise performance. However, optimal electrode placement for tDCS remains unclear. We tested the effect of two different tDCS electrode montages for improving exercise performance. Nine subjects underwent a control (CON), placebo (SHAM) and two different tDCS montage sessions in a randomized design. In one tDCS session, the anodal electrode was placed over the left motor cortex and the cathodal on contralateral forehead (HEAD), while for the other montage the anodal electrode was placed over the left motor cortex and cathodal electrode above the shoulder (SHOULDER). tDCS was delivered for 10min at 2.0mA, after which participants performed an isometric time to exhaustion (TTE) test of the right knee extensors. Peripheral and central neuromuscular parameters were assessed at baseline, after tDCS application and after TTE. Heart rate (HR), ratings of perceived exertion (RPE), and leg muscle exercise-induced muscle pain (PAIN) were monitored during the TTE. TTE was longer and RPE lower in the SHOULDER condition (P<0.05). Central and peripheral parameters, and HR and PAIN did not present any differences between conditions after tDCS stimulation (P>0.05). In all conditions maximal voluntary contraction (MVC) significantly decreased after the TTE (P<0.05) while motor-evoked potential area (MEP) increased after TTE (P<0.05). These findings demonstrate that SHOULDER montage is more effective than HEAD montage to improve endurance performance, likely through avoiding the negative effects of the cathode on excitability.

Modeling Intermittent Running from a Single-visit Field Test.

This study assessed whether the distance-time relationship could be modeled to predict time to exhaustion (TTE) during intermittent running. 13 male distance runners (age: 33±14 years) completed a field test and 3 interval tests on an outdoor 400 m athletic track. Field-tests involved trials over 3 600 m, 2 400 m and 1 200 m with a 30-min rest between each run. Interval tests consisted of: 1 000 m at 107% of CS with 200 m at 95% CS; 600 m at 110% of CS with 200 m at 90% CS; 200 m at 150% of CS with 200 m at 80% CS. Interval sessions were separated by 24 h recovery. Field-test CS and D' were applied to linear and non-linear models to estimate the point of interval session termination. Actual and predicted TTE using the linear model were not significantly different in the 1 000 m and 600 m trials. Actual TTE was significantly lower (P=0.01) than predicted TTE in the 200 m trial. Typical error was high across the trials (range 334-1 709 s). The mean balance of D' remaining at interval session termination was significantly lower when estimated from the non-linear model (-21.2 vs. 13.4 m, P<0.01), however no closer to zero than the linear model. Neither the linear or non-linear model could closely predict TTE during intermittent running.

Validity and reliability of critical power field testing.

PURPOSE: To test the validity and reliability of field critical power (CP). METHOD: Laboratory CP tests comprised three exhaustive trials at intensities of 80, 100 and 105 % maximal aerobic power and CP results were compared with those determined from the field. Experiment 1: cyclists performed three CP field tests which comprised maximal efforts of 12, 7 and 3 min with a 30 min recovery between efforts. Experiment 2: cyclists performed 3 × 3, 3 × 7 and 3 × 12 min individual maximal efforts in a randomised order in the field. Experiment 3: the highest 3, 7 and 12 min power outputs were extracted from field training and racing data. RESULTS: Standard error of the estimate of CP was 4.5, 5.8 and 5.2 % for experiments 1-3, respectively. Limits of agreement for CP were -26 to 29, 26 to 53 and -34 to 44 W for experiments 1-3, respectively. Mean coefficient of variation in field CP was 2.4, 6.5 and 3.5 % for experiments 1-3, respectively. Intraclass correlation coefficients of the three repeated trials for CP were 0.99, 0.96 and 0.99 for experiments 1-3, respectively. CONCLUSIONS: Results suggest field-testing using the different protocols from this research study, produce both valid and reliable CP values.

Improved gross efficiency during long duration submaximal cycling following a short-term high carbohydrate diet.

To assess the effect of dietary manipulation on gross efficiency (GE), 15 trained male cyclists completed 3×2 h tests at submaximal exercise intensity (60% Maximal Minute Power). Using a randomized, crossover design participants consumed an isoenergetic diet (~4 000 kcal.day-1) in the 3 days preceding each test, that was either high in carbohydrate (HighCHO, [70% of the total energy derived from carbohydrate, 20% fat, 10% protein]), low in carbohydrate (LowCHO, [70% fat, 20% carbohydrate, 10% protein]) or contained a moderate amount of carbohydrate (ModCHO, [45% carbohydrate, 45% fat, 10% protein]). GE along with blood lactate and glucose were assessed every 30 min, and heart rate was measured at 5 s intervals throughout. Mean GE was significantly greater following the HighCHO than the ModCHO diet (HighCHO=20.4%±0.1%, ModCHO=19.6±0.2%; P<0.001). Additionally, HighCHO GE was significantly greater after 25 min (P=0.015) and 85 min (P=0.021) than in the LowCHO condition. Heart rate responses in the HighCHO condition were significantly lower than during the LowCHO tests (P=0.005). Diet had no effect on blood glucose or lactate (P>0.05). This study suggests that before the measurement of gross efficiency, participants' diet should be controlled and monitored to ensure the validity of the results obtained.

High agreement between laboratory and field estimates of critical power in cycling.

The purpose of this study was to investigate the level of agreement between laboratory-based estimates of critical power (CP) and results taken from a novel field test. Subjects were fourteen trained cyclists (age 40±7 yrs; body mass 70.2±6.5 kg; VO2max 3.8±0.5 L · min-1). Laboratory-based CP was estimated from 3 constant work-rate tests at 80%, 100% and 105% of maximal aerobic power (MAP). Field-based CP was estimated from 3 all-out tests performed on an outdoor velodrome over fixed durations of 3, 7 and 12 min. Using the linear work limit (Wlim) vs. time limit (Tlim) relation for the estimation of CP1 values and the inverse time (1/t) vs. power (P) models for the estimation of CP2 values, field-based CP1 and CP2 values did not significantly differ from laboratory-based values (234±24.4 W vs. 234±25.5 W (CP1); P<0.001; limits of agreement [LOA], -10.98-10.8 W and 236±29.1 W vs. 235±24.1 W (CP2); P<0.001; [LOA], -13.88-17.3 W. Mean prediction errors for laboratory and field estimates were 2.2% (CP) and 27% (W'). Data suggest that employing all-out field tests lasting 3, 7 and 12 min has potential utility in the estimation of CP.

The 3-min test does not provide a valid measure of critical power using the SRM isokinetic mode.

Recent datas suggest that the mean power over the final 30 s of a 3-min all-out test is equivalent to Critical Power (CP) using the linear ergometer mode. The purpose of the present study was to identify whether this is also true using an "isokinetic mode". 13 cyclists performed: 1) a ramp test; 2) three 3-min all-out trials to establish End Power (EP) and work done above EP (WEP); and 3) 3 constant work rate trials to determine CP and the work done above CP (W') using the work-time (=CP1/W'1) and 1/time (=CP2/W'2) models. Coefficient of variation in EP was 4.45% between trials 1 and 2, and 4.29% between trials 2 and 3. Limits of Agreement for trials 1-2 and trials 2-3 were -2±38 W. Significant differences were observed between EP and CP1 (+37 W, P<0.001), between WEP and W'1(-6.2 kJ, P=0.001), between EP and CP2 (+31 W, P<0.001) and between WEP and W'2 (-4.2 kJ, P=0.006). Average SEE values for EP-CP1 and EP-CP2 of 7.1% and 6.6% respectively were identified. Data suggest that using an isokinetic mode 3-min all-out test, while yielding a reliable measure of EP, does not provide a valid measure of CP.

The effect of turbo trainer cycling on pedalling technique and cycling efficiency.

Cycling can be performed on the road or indoors on stationary ergometers. The purpose of this study was to investigate differences in cycling efficiency, muscle activity and pedal forces during cycling on a stationary turbo trainer compared with a treadmill. 19 male cyclists cycled on a stationary turbo trainer and on a treadmill at 150, 200 and 250 W. Cycling efficiency was determined using the Douglas bags, muscle activity patterns were determined using surface electromyography and pedal forces were recorded with instrumented pedals. Treadmill cycling induced a larger muscular contribution from Gastrocnemius Lateralis, Biceps Femoris and Gluteus Maximus of respectively 14%, 19% and 10% compared with turbo trainer cycling (p<0.05). Conversely, Turbo trainer cycling induced larger muscular contribution from Vastus Lateralis, Rectus Femoris and Tibialis Anterior of respectively 7%, 17% and 14% compared with treadmill cycling (p<0.05). The alterations in muscle activity resulted in a better distribution of power during the pedal revolution, as determined by an increased Dead Centre size (p<0.05). Despite the alterations in muscle activity and pedalling technique, no difference in efficiency between treadmill (18.8±0.7%) and turbo trainer (18.5±0.6%) cycling was observed. These results suggest that cycling technique and type of ergometer can be altered without affecting cycling efficiency.

Inter- and intra-session reliability of muscle activity patterns during cycling.

The aim of this study was to determine the inter- and intra-session reliability of the temporal and magnitude components of activity in eight muscles considered important for the leg cycling action. On three separate occasions, 13 male non-cyclists and 11 male cyclists completed 6 min of cycling at 135, 150, and 165 W. Cyclists completed two additional 6-min bouts at 215 and 265 W. Surface electromyography was used to record the electrical activity of tibialis anterior, soleus, gastrocnemius medialis, gastrocnemius lateralis, vastus medialis, vastus lateralis, rectus femoris, and gluteus maximus. There were no differences (P > 0.05) in the muscle activity onset and offset or in the iEMG of any muscles between visits. There were also no differences (P > 0.05) between cyclists and non-cyclists in the variability of these parameters. Overall, standard error of measurement (SEM) and intra-class correlation analyses suggested similar reliability of both inter- and intra-session muscle activity onset and offset. The SEM of activity onset in tibialis anterior and activity offset in soleus, gastrocnemius lateralis and rectus femoris was markedly higher than in the other muscles. Intra-session iEMG was reliable (coefficient of variation (CV) = 5.3-13.5%, across all muscles), though a CV range of 15.8-43.1% identified low inter-session iEMG reliability. During submaximal cycling, the temporal components of muscle activity exhibit similar intra- and inter-session reliability. The magnitude component of muscle activity is reliable on an intra-session basis, but not on an inter-session basis.

Inverse relationship between V˙O2max and gross efficiency.

The aim of this study was to identify if an inverse relationship exists between Gross Efficiency (GE) and V˙O2max in trained cyclists. In Experiment 1, 14 trained cyclist's GE and V˙O2max were recorded at 5 different phases of a cycling 'self-coached' season using an incremental laboratory test. In Experiment 2, 29 trained cyclists undertook 12 weeks of training in one of 2 randomly allocated groups (A and B). Over the first 6 weeks Group A was prescribed specific high-intensity training sessions, whilst Group B were restricted in the amount of intensive work they could conduct. In the second 6-week period, both groups were allowed to conduct high intensity training. Results of both experiments in this study demonstrate training related increases in GE, but not V˙O2max. A significant inverse within-subject correlation was evident in experiment 1 between GE and V˙O2max across the training season (r=-0.32; P<0.05). In experiment 2, a significant inverse within-subject correlation was found between changes in GE and V˙O2max in Group A over the first 6 weeks of training (r=-0.78; P<0.01). Resultantly, a training related inverse relationship between GE and V˙O2max is evident in these groups of trained cyclists.

Controversies in the physiological basis of the 'anaerobic threshold' and their implications for clinical cardiopulmonary exercise testing.

This article reviews the notion of the 'anaerobic threshold' in the context of cardiopulmonary exercise testing. Primarily, this is a review of the proposed mechanisms underlying the ventilatory and lactate response to incremental exercise, which is important to the clinical interpretation of an exercise test. Since such tests are often conducted for risk stratification before major surgery, a failure to locate or justify the existence of an anaerobic threshold will have some implications for clinical practice. We also consider alternative endpoints within the exercise response that might be better used to indicate a patient's capacity to cope with the metabolic demands encountered both during and following major surgery.

Validity and reliability of the Wattbike cycle ergometer.

The purpose of this study was to assess the validity and reliability of the Wattbike cycle ergometer against the SRM Powermeter using a dynamic calibration rig (CALRIG) and trained and untrained human participants. Using the CALRIG power outputs of 50-1 250 W were assessed at cadences of 70 and 90 rev x min(-1). Validity and reliability data were also obtained from 3 repeated trials in both trained and untrained populations. 4 work rates were used during each trial ranging from 50-300 W. CALRIG data demonstrated significant differences (P<0.05) between SRM and Wattbike across the work rates at both cadences. Significant differences existed in recorded power outputs from the SRM and Wattbike during steady state trials (power outputs 50-300 W) in both human populations (156±72 W vs. 153±64 W for SRM and Wattbike respectively; P<0.05). The reliability (CV) of the Wattbike in the untrained population was 6.7% (95%CI 4.8-13.2%) compared to 2.2% with the SRM (95%CI 1.5-4.1%). In the trained population the Wattbike CV was 2.6% (95%CI 1.8-5.1%) compared to 1.1% with the SRM (95%CI 0.7-2.0%). These results suggest that when compared to the SRM, the Wattbike has acceptable accuracy. Reliability data suggest coaches and cyclists may need to use some caution when using the Wattbike at low power outputs in a test-retest setting.

The effects of training on gross efficiency in cycling: a review.

There has been much debate in the recent scientific literature regarding the possible ability to increase gross efficiency in cycling via training. Using cross-sectional study designs, researchers have demonstrated no significant differences in gross efficiency between trained and untrained cyclists. Reviewing this literature provides evidence to suggest that methodological inadequacies may have played a crucial role in the conclusions drawn from the majority of these studies. We present an overview of these studies and their relative shortcomings and conclude that in well-controlled and rigorously designed studies, training has a positive influence upon gross efficiency. Putative mechanisms for the increase in gross efficiency as a result of training include, muscle fibre type transformation, changes to muscle fibre shortening velocities and changes within the mitochondria. However, the specific mechanisms by which training improves gross efficiency and their impact on cycling performance remain to be determined.

Validity and reliability of the Ergomopro powermeter.

The aim of this investigation was to assess the validity and reliability of the Ergomopro powermeter. Nine participants completed trials on a Monark ergometer fitted with Ergomopro and SRM powermeters simultaneously recording power output. Each participant completed multiple trials at power outputs ranging from 50 to 450 W. The work stages recorded were 60 s in duration and were repeated three times. Participants also completed a single trial on a cycle ergometer designed to assess bilateral contributions to work output (Lode Excaliber Sport PFM). The power output during the trials was significantly different between all three systems, (p < 0.01) 231.2 +/- 114.2 W, 233.0 +/- 112.4 W, 227.8 +/- 108.8 W for the Monark, SRM and Ergomopro system, respectively. When the bilateral contributions were factored into the analysis, there were no significant differences between the powermeters (p = 0.58). The reliability of the Ergomopro system (CV%) was 2.31 % (95 % CI 2.13 - 2.52 %) compared to 1.59 % (95 % CI 1.47 to 1.74 %) for the Monark, and 1.37 % (95 % CI 1.26 - 1.50 %) for the SRM powermeter. These results indicate that the Ergomopro system has acceptable accuracy under these conditions. However, based on the reliability data, the increased variability of the Ergomopro system and bilateral balance issues have to be considered when using this device.