In vitro initial stability of a stemless humeral implant.

BACKGROUND: Stemless humeral prostheses have been recently introduced. We measured for the first time their in vitro primary stability and analyzed the influence of three clinically important parameters (bone quality, implant size and post-operative loading) on micromotion. We also assessed if displacement sensors are appropriate to measure implant micromotion. METHODS: A stemless humeral implant (Sidus® Stem-Free Shoulder, Zimmer GmbH, Winterthur, Switzerland) was implanted in 18 cadaveric humeri. Three-dimensional motion of the implant was measured under dynamic loading at three load magnitudes with displacement sensors. Additionally, the relative motion at the bone-implant interface was measured with an optical system in four specimens. RESULTS: Micromotion values derived from the displacement sensors were significantly higher than those measured by the optical system (P<0.005). Analysis of variance (ANOVA) indicated that bone density (P<0.0005) and load (P<0.0001) had a significant effect on implant micromotion, however the effect of implant size was not statistically significant (P=0.123). INTERPRETATION: Micromotion of this stemless design was shown to be significantly dependent on cancellous bone density. Patients must therefore have adequate bone quality for this procedure. The influence of load magnitude on micromotion emphasizes the need for controlled post-operative rehabilitation. Measurements with displacement sensors overestimate true interface micromotion by up to 50% and correction by an optical system is strongly recommended.

Finite element analysis of unicompartmental knee arthroplasty.

Concerns over accelerated damage to the untreated compartment of the knee following unicompartmental knee arthroplasty (UKA), as well as the relatively poor success rates observed for lateral as opposed to the medial arthroplasty, remain issues for attention. Finite element analysis (FEA) was used to assess changes to the kinematics and potential for cartilage damage across the knee joint in response to the implantation of the Oxford Mobile Bearing UKA. FE models of lateral and medial compartment arthroplasty were developed, in addition to a healthy natural knee model, to gauge changes incurred through the arthroplasty. Varus-valgus misalignments were introduced to the femoral components to simulate surgical inaccuracy or over-correction. Boundary conditions from the Stanmore knee simulator during the stance phase of level gait were used. AP translations of the tibia in the medial UKA models were comparable to the behaviour of the natural knee models (+/-0.6mm deviation from pre-operative motion). Following lateral UKA, 4.1mm additional posterior translation of the tibia was recorded than predicted for the natural knee. IE rotations of the medial UKA models were less consistent with the pre-operative knee model than the lateral UKA models (7.7 degrees vs. 3.6 degrees deviation). Varus misalignment of the femoral prosthesis was more influential than valgus for medial UKA kinematics, whereas in lateral UKA, a valgus misalignment of the femoral prosthesis was most influential on the kinematics. Resection of the cartilage in the medial compartment reduced the overall risk of progressive OA in the knee, whereas removing the cartilage from the lateral compartment, and in particular introducing a valgus femoral misalignment, increased the overall risk of progressive OA in the knee. Based on these results, under the conditions tested herein, both medial and lateral UKA can be said to induce kinematics of the knee which could be considered broadly comparable to those of the natural knee, and that even a 10 degrees varus-valgus misalignment of the femoral component may not induce highly irregular kinematics. However, elevated posterior translation of the tibia in lateral UKA and large excursions of the insert may explain the higher incidence of bearing dislocation observed in some clinical studies.

Fixation of the reversed shoulder prosthesis.

The last decade has seen an increased interest in reversed shoulder prostheses. Success rates with these designs have been varied, with initial performance marred by failures resulting from improper implant alignment and an emerging engineering understanding. Competitor products to the well-documented Grammont design have yielded increasingly high success rates. Understanding the relationships between implant design, surgical procedure, and clinical outcome is important so that current results can be improved upon. This study considers the performance of 3 different reversed shoulder designs from the perspective of osseointegration, with the results broadly validated through comparison with experimental data. Finite element modeling was used to clarify the relationships between lateral offset of the center of rotation, screw insertion angle, screw length, screw diameter, bone material quality, and the potential for interdigitation of the supporting bone onto the reversed prosthesis. The results indicate that screw length, insertion angle, and diameter, when maximized, allow the least relative motion between the implant and underlying bone. When the bone is stiffer, the relative motion of the implant is lower. In almost all scenarios modeled, the interface micromotion was small enough to suggest that the glenoid was stable enough to encourage bone ingrowth across the majority of the bone-implant interfaces.

Wear in the prosthetic shoulder: association with design parameters.

Total replacement of the glenohumeral joint provides an effective means for treating a variety of pathologies of the shoulder. However, several studies indicate that the procedure has not yet been entirely optimized. Loosening of the glenoid component remains the most likely cause of implant failure, and generally this is believed to stem from either mechanical failure of the fixation in response to high tensile stresses, or through osteolysis of the surrounding bone stock in response to particulate wear debris. Many computational studies have considered the potential for the former, although only few have attempted to tackle the latter. Using finite-element analysis an investigation, taking into account contact pressures as well as glenohumeral kinematics, has thus been conducted, to assess the potential for polyethylene wear within the artificial shoulder. The relationships between three different aspects of glenohumeral design and the potential for wear have been considered, these being conformity, polyethylene thickness, and fixation type. The results of the current study indicate that the use of conforming designs are likely to produce slightly elevated amounts of wear debris particles when compared with less conforming joints, but that the latter would be more likely to cause material failure of the polyethylene. The volume of wear debris predicted was highly influenced by the rate of loading, however qualitatively it was found that wear predictions were not influenced by the use of different polyethylene thicknesses nor fixation type while the depth of wearing was. With the thinnest polyethylene designs (2 mm) the maximum depth of the wear scar was seen to be upwards of 20% higher with a metal-backed fixation as opposed to a cemented design. In all-polyethylene designs peak polymethyl methacrylate tensile stresses were seen to reduce with increasing polyethylene thickness. Irrespective of the rate of loading of the shoulder joint, the current study indicates that it is possible to optimize glenoid component design against abrasive wear through the use of high conformity designs, possessing a polyethylene thickness of at least 6 mm.

Glenohumeral kinematics following total shoulder arthroplasty: a finite element investigation.

The osseous geometry of the glenohumeral joint is naturally nonconforming and minimally constrained, and the joint's stability is maintained by action of the rotator cuff muscles. Damage to these muscles is often associated with joint degeneration, and a variety of glenoid prostheses have been developed to impart varying degrees of stability postoperatively. The issues of conformity and constraint within the artificial shoulder have been addressed through in vivo and in vitro studies, although few computational models have been presented. The current investigation presents the results of three-dimensional finite element analyses of the total shoulder joint and the effects of design parameters upon glenohumeral interaction. Conformity was shown not to influence the loads required to destabilize the joint, although it was the principal factor determining the magnitude of humeral head translation. Constraint was found to correlate linearly with the forces required to dislocate the humeral head, with higher constraint leading to slightly greater humeral migration at the point of joint instability. The model predicts that patients with a dysfunctional supraspinatus would experience frequent eccentric loading of the glenoid, especially in the superior direction, which would likely lead to increased fixation stresses, and hence, a greater chance of loosening. For candidates with an intact rotator cuff, the models developed in this study predict that angular constraints of at least 14 degrees and 6.5 degrees in the superoinferior and anteroposterior axes are required to provide stable unloaded abduction of the humerus, with larger constraints of 18 degrees and 10 degrees necessitated by a dysfunctional supraspinatus. The tools developed during this study can be used to determine the capacity for different implant designs to provide resistance to excessive glenohumeral translations and reduce the potential for instability of the joint, allowing surgeons to optimize postoperative functional gains on a patient by patient basis.

Finite element modelling of glenohumeral kinematics following total shoulder arthroplasty.

Due to the shallowness of the glenohumeral joint, a challenging but essential requirement of a glenohumeral prosthesis is the prevention of joint dislocation. Weak glenoid bone stock and frequent dysfunction of the rotator cuff, both of which are common with rheumatoid arthritis, make it particularly difficult to achieve this design goal. Although a variety of prosthetic designs are commercially available only a few experimental studies have investigated the kinematics and dislocation characteristics of design variations. Analytical or numerical methods, which are predictive and more cost-effective, are, apart from simple rigid-body analyses, non-existent. The current investigation presents the results of a finite element analysis of the kinematics of a total shoulder joint validated using recently published experimental data for the same prostheses. The finite element model determined the loading required to dislocate the humeral head, and the corresponding translations, to within 4% of the experimental data. The finite element method compared dramatically better to the experimental data (mean difference=2.9%) than did rigid-body predictions (mean difference=37%). The goal of this study was to develop an accurate method that in future studies can be used for further investigations of the effect of design parameters on dislocation, particularly in the case of a dysfunctional rotator cuff. Inherently, the method also evaluates the glenoid fixation stresses in the relatively weak glenoid bone stock. Hence, design characteristics can be simultaneously optimised against dislocation as well as glenoid loosening.

Finite element models of total shoulder replacement: application of boundary conditions.

The widespread use of FEA within orthopaedics is often prohibited by the limits of available computational power, with simplifications to the model often necessary in order to permit solution. An example of this includes the use of osseous models that exclude muscular loading, and may consist of only a partial or truncated region of the anatomy. However, is it possible to make such simplifications without affecting the predictive quality of the model? This issue has been considered using the specific example of the total shoulder reconstruction, where the effects of including the entire osseous region and/or the muscle loadings, has been evaluated. The effect of including the muscle loadings and the entire osseous structure was seen to increase with distance from the articular surface of the glenoid prosthesis. Stresses in the cement mantle were reduced in the absence of either the entire scapula bone or the muscle loading. The study suggests that the use of a fully defined scapula (hard- and soft-tissue) is particularly important when investigating fixation, whilst less comprehensive models should be appropriate for studies of the prosthesis exclusively.

The effects of glenoid component alignment variations on cement mantle stresses in total shoulder arthroplasty.

Loosening of the glenoid component has been cited as the most frequent cause of patient dissatisfaction with total shoulder arthroplasty, and it has been demonstrated in clinical studies that misalignment of the prostheses can be a causative factor. Finite element analyses of five different glenoid component alignments (central, anteverted, retroverted, inferiorly inclined, and superiorly inclined) were conducted in order to predict changes in the survivability of the cement mantle surrounding the glenoid component. The potential for mechanical failure of the mantle in the centrally aligned implant, during unloaded abduction, was seen to be lower than for any other alignment. Normal bone outperformed simulated rheumatoid models in all cases. Retroversion was worse than anteversion, and superoinferior misalignment was worse than anteroposterior. The quality of the supporting bone stock was found to be particularly significant to cement survivability, more so than the occurrence of eccentric loading of the joint. Shear forces acting on the glenoid component were found to be more detrimental than axial forces, resulting in a greater likelihood of failure toward the extremes of motion. The study suggests that significant efforts should be made to align the glenoid component correctly and also to ensure suitably consistent support of the prosthesis within the bone.