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BMJ Open ; 12(2): e059160, 2022 Feb 14.
Article in English | MEDLINE | ID: mdl-35165115

ABSTRACT

INTRODUCTION: Chronic kidney disease (CKD) and cardiac disease are two significant health conditions that can impact a women's pregnancy; however, little is known about their prevalence and health impact within the population. These pregnancies are associated with significant risks of morbidity and mortality and propose a challenge to clinicians. The aim of this longitudinal cohort study is to prospectively record the incidence, prevalence, aetiology, outcomes and follow-up of maternal CKD and cardiac disease in the obstetric population of South Australia. METHODS AND ANALYSIS: This study is a state-wide multicentre prospective cohort study in South Australia that will begin recruitment in 2022 and is planned for at least 5 years. Pregnant women with chronic or acquired kidney or cardiac disease will be enrolled across the state's major public obstetric hospitals. The data collected will focus on the chronic disease aetiology, peripartum interventions, delivery, obstetric and neonatal outcomes, progression of underlying disease and patient-related outcome measures. Women will have data collected each trimester during pregnancy and then at follow-up 6 weeks, 6 months and 12 months post partum. Clear inclusion and exclusion criteria have been developed which importantly includes new diagnosis of chronic disease in pregnancy. ETHICS AND DISSEMINATION: Approval was obtained from the local Health Network Human Research Ethics Committee. Summary data will be reviewed and reported in accordance with Strengthening the Reporting of Observational Studies in Epidemiology criteria 6 monthly and results will be published in peer-reviewed journals and presented at conferences. Findings will be presented to relevant local clinicians and hospitals at regular intervals. Consumer versions of research outputs will be developed in conjunction with the consumer reference group.


Subject(s)
Heart Diseases , Renal Insufficiency, Chronic , Australia/epidemiology , Cohort Studies , Female , Heart Diseases/epidemiology , Humans , Infant, Newborn , Kidney , Longitudinal Studies , Multicenter Studies as Topic , Pregnancy , Prospective Studies , Renal Insufficiency, Chronic/epidemiology , South Australia/epidemiology
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