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Eur J Clin Pharmacol ; 46(5): 481-3, 1994.
Article in English | MEDLINE | ID: mdl-7957549

ABSTRACT

The genetic oxidation polymorphism was determined in 160 healthy Polish volunteers from the south-west of Poland (Wroclaw region), using sparteine as a model drug. The results of a Polish population study revealed a bimodal distribution of the sparteine metabolic ratio and showed the existence of two oxidation phenotypes designated as extensive and poor metabolizers. The frequency of poor metabolizers in our study (8.8%) compares well with most results of poor oxidation metabolizers in Caucasian populations.


Subject(s)
Polymorphism, Genetic , Sparteine/pharmacokinetics , Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Oxidation-Reduction , Poland , Sparteine/metabolism
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