Subject(s)
Humans , Male , Female , Infant , Child , Adolescent , Skin Neoplasms/diagnostic imaging , Myofibroma/diagnostic imaging , Diagnosis, Differential , UltrasonographyABSTRACT
ANTECEDENTES Y OBJETIVOS: El Wound-QoL es un cuestionario validado para medir la calidad de vida en pacientes con heridas crónicas, que fue desarrollado originalmente para su uso en alemán. El objetivo de este estudio fue traducir el cuestionario Wound-QoL para su uso en la práctica clínica y estudios de investigación en España, así como validar esta versión. MATERIALES Y MÉTODOS: Se realizaron dos traducciones independientes del Wound-QoL, directa e inversa, a partir de la versión original en alemán, seguidas de un consenso de expertos sobre las versiones resultantes. Después de su perfeccionamiento se realizó un estudio piloto y posteriormente el estudio de validación. RESULTADOS: Se incluyó un total de 115 pacientes. La edad media fue de 69,5 (DE 14,5) años, y el 60,0% eran mujeres. La versión española del Wound-QoL mostró una excelente consistencia interna (índice alfa de Cronbach > 0,8 en todas las escalas). El análisis factorial dio como resultado las mismas escalas que la versión original. Se objetivaron características satisfactorias de la distribución de la puntuación global y de las subescalas. La validez de constructo y la validez convergente con otros resultados (calidad de vida genérica, tasa de curación) fueron satisfactorias. La gran mayoría de los pacientes consideraron que el cuestionario era una herramienta sencilla y factible. El tiempo medio necesario para completar el cuestionario fue de 5 minutos. El 99,1% de los participantes consideraron que las preguntas eran fáciles de entender y el 94,7% declaró que personal. CONCLUSIONES: La versión española del Wound-QoL muestra una excelente validez en la práctica clínica. Por lo tanto, puede ser recomendada para su uso tanto en la rutina clínica como en los ensayos
BACKGROUND AND AIMS: The Wound-QoL is a validated and feasible questionnaire for measuring disease-specific health-related quality of life in chronic wounds, originally developed for use in German. The objective of this study was to translate the Wound-QoL for use in clinical care and in clinical trials in Spain and to validate this version. MATERIALS AND METHODS: Two independent fourth- and back translations of the Wound-QoL from the original German version were conducted, followed by an expert consensus of the resulting versions. After refinement, the final tool was piloted in N = 10 patients and then used in the validation study. RESULTS: A total of 115 patients were recruited. Mean age was 69.5 (SD 14.5) years, 60.0% were female. The Spanish version of Wound-QoL showed high internal consistency (Cronbach's alpha > 0.8 in all scales). Factor analysis resulted in the same scales as the original version. There were satisfactory distribution characteristics of the global score and the subscales. Construct validity and convergent validity with other outcomes (generic QoL, healing rate) were satisfactory. The vast majority of patients considered the Wound-QoL a simple and feasible tool. Mean time needed for completing the questionnaire was 5 minutes. Overall, 99.1% of the participants found it easy to understand the questions and 94.7% stated that the questionnaire suits the personal situation. CONCLUSIONS. The Spanish version of the Wound-QoL shows good validity in clinical practice. It can be recommended for use in clinical routine and trials
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Surveys and Questionnaires/standards , Translations , Quality of Life , Wounds and Injuries/physiopathology , Prospective Studies , Reproducibility of Results , Spain , Chronic DiseaseABSTRACT
BACKGROUND AND AIMS: The Wound-QoL is a validated and feasible questionnaire for measuring disease-specific health-related quality of life in chronic wounds, originally developed for use in German. The objective of this study was to translate the Wound-QoL for use in clinical care and in clinical trials in Spain and to validate this version. MATERIALS AND METHODS: Two independent fourth- and back translations of the Wound-QoL from the original German version were conducted, followed by an expert consensus of the resulting versions. After refinement, the final tool was piloted in N=10 patients and then used in the validation study. RESULTS: A total of 115 patients were recruited. Mean age was 69.5 (SD 14.5) years, 60.0% were female. The Spanish version of Wound-QoL showed high internal consistency (Cronbach's alpha>0.8 in all scales). Factor analysis resulted in the same scales as the original version. There were satisfactory distribution characteristics of the global score and the subscales. Construct validity and convergent validity with other outcomes (generic QoL, healing rate) were satisfactory. The vast majority of patients considered the Wound-QoL a simple and feasible tool. Mean time needed for completing the questionnaire was 5minutes. Overall, 99.1% of the participants found it easy to understand the questions and 94.7% stated that the questionnaire suits the personal situation. CONCLUSIONS: The Spanish version of the Wound-QoL shows good validity in clinical practice. It can be recommended for use in clinical routine and trials.
Subject(s)
Quality of Life , Translations , Aged , Factor Analysis, Statistical , Female , Humans , Spain , Surveys and QuestionnairesABSTRACT
No disponible
Subject(s)
Humans , Male , Middle Aged , Thrombophlebitis/diagnostic imaging , Radiography, Thoracic/methods , Remission, Spontaneous , Watchful WaitingSubject(s)
Thoracic Wall/pathology , Thrombophlebitis/diagnosis , Humans , Male , Middle Aged , Thrombophlebitis/physiopathologyABSTRACT
Photodynamic therapy (PDT) involves the use of photochemical reactions mediated through the interaction of photosensitizing agents, light, and oxygen for the treatment of malignant or benign diseases. Topical photosensitizers employed in dermatology are 5-aminolevulinic acid (5 ALA) and methyl aminolevulinate, classically used for the treatment of superficial non-melanoma skin cancer and their precursors. Recently the efficacy of PDT has been introduced in other benign diseases. Elastosis perforans serpiginosa (EPS) is a rare skin disorder characterized by transepidermal elimination of abnormal elastic fibers. Management of this condition is complicated, various methods have been used but with limited success. We report a case of EPS in a 30-yeard-old woman treated with 5 ALA-PDT. After 4 sessions the lesions have almost completely disappeared with no residual side effects. Therefore we present an effective and safe alternative for the treatment of EPS.
Subject(s)
Aminolevulinic Acid/therapeutic use , Photochemotherapy/methods , Photosensitizing Agents/therapeutic use , Skin Diseases/drug therapy , Adult , Female , HumansABSTRACT
La pustulosis exantemática generalizada aguda, el síndrome de Stevens-Johnson, la necrólisis epidérmica tóxica y el síndrome de hipersensibilidad a fármacos con síntomas sistémicos y eosinofilia son reacciones de hipersensibilidad grave a fármacos. Aunque cada una de ellas se describe como una entidad bien constituida con criterios diagnósticos propios, en la práctica clínica se encuentran algunos casos que manifiestan características de 2 de estas entidades, abriendo el diálogo ante la posible existencia de formas combinadas. La existencia de estas formas solapadas entre 2 toxicodermias graves es motivo de controversia en los últimos años en diferentes foros de dermatología. En el artículo se aportan 2 nuevos casos de formas solapadas entre pustulosis exantemática generalizada aguda y síndrome de Stevens-Johnson/necrólisis epidérmica tóxica, se revisan los casos previos publicados y el estado actual de esta controversia en la literatura
Acute generalized exanthematous pustulosis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms are all severe hypersensitivity reactions to medications. While each of these reactions is a well-established entity with specific diagnostic criteria, clinicians see cases that fulfill criteria for more than one form, prompting discussion on the possibility of combined forms. Such overlapping clinical pictures meeting the criteria for 2 conditions have thus become a topic of debate in dermatology in recent years. We describe 2 patients with cutaneous drug reactions having the characteristics of both acute generalized exanthematous pustulosis and Stevens-Johnson syndrome -toxic epidermal necrolysis. We also review previously published cases and current thinking on such overlapping conditions
Subject(s)
Humans , Male , Female , Aged , Aged, 80 and over , Skin Diseases, Vesiculobullous/complications , Acute Generalized Exanthematous Pustulosis/complications , Acute Generalized Exanthematous Pustulosis/therapy , Skin Diseases, Vesiculobullous/chemically induced , Stevens-Johnson Syndrome/complications , Stevens-Johnson Syndrome/therapy , Drug Eruptions/complications , Drug Eruptions/therapy , Drug Hypersensitivity/complications , Drug Hypersensitivity/diagnosis , Drug Hypersensitivity/therapy , Diagnosis, DifferentialABSTRACT
Acute generalized exanthematous pustulosis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms are all severe hypersensitivity reactions to medications. While each of these reactions is a well-established entity with specific diagnostic criteria, clinicians see cases that fulfill criteria for more than one form, prompting discussion on the possibility of combined forms. Such overlapping clinical pictures meeting the criteria for 2 conditions have thus become a topic of debate in dermatology in recent years. We describe 2 patients with cutaneous drug reactions having the characteristics of both acute generalized exanthematous pustulosis and Stevens-Johnson syndrome -toxic epidermal necrolysis. We also review previously published cases and current thinking on such overlapping conditions.
