ABSTRACT
To establish a modified homomorphic filter (BiFiC) for post-processing of composed MR images in clinical routine and to evaluate it in special regards to image quality and diagnostic safety. Twenty-three whole-spine examinations were post-processed with the filter. Qualitative image evaluation included documentation of lesions and their visualization at original and post-processed images. Variations of signal intensities were calculated pixel by pixel and visualized by color-coded maps. Quantitative data evaluation was conducted by region-by-region analysis with standardized regions of interests. The BiFiC filter could be implemented successfully on the scanner's software platform and used within clinical routine. Color-coded maps could demonstrate that the BiFiC filter improves the signal uniformity in all cases, including images with metallic artifacts caused by implants. The subjective image quality of the post-processed images was improved in 22 out of the 23 MR examinations; in one case it was rated as equal. All pathologies were visualized on post-processed images without the need of additional contrast adjustments. The implemented BiFiC filter significantly improves image signal homogeneity. The algorithm can consequently be integrated into clinical routine as an automatic image post-processing step.
Subject(s)
Image Enhancement/methods , Image Interpretation, Computer-Assisted/methods , Magnetic Resonance Imaging/methods , Multiple Myeloma/diagnosis , Signal Processing, Computer-Assisted , Spinal Neoplasms/diagnosis , Spine/pathology , Algorithms , Female , Humans , Male , Middle Aged , Pilot Projects , Reproducibility of Results , Sensitivity and SpecificityABSTRACT
PURPOSE: Evaluation of the global and regional reproducibility of T2 relaxation time in patellar cartilage at 1.5 T and 3 T. MATERIALS AND METHODS: 6 left patellae of 6 healthy volunteers (aged 25 - 30, 3 female, 3 male) were examined using a fat-saturated multiecho sequence and a T1-w 3D-FLASH sequence with water excitation at 1.5 Tesla and 3 Tesla. Three consecutive data sets were acquired within one MRI session with the examined knee being repositioned in the coil and scanner between each data set. The segmented cartilage (FLASH sequence) was overlaid on the multiecho data and T2 values were calculated for the total cartilage, 3 horizontal layers consisting of a superficial, intermedial and deep layer, 3 facets consisting of a medial, median (ridge) and lateral facet (global T2 values) and 27 ROIs/MRI slices (regional T2 value). The reproducibility (precision error) was calculated as the root mean square average of the individual standard deviations [ms] and coefficients of variation (COV) [%]. RESULTS: The mean global reproducibility error for T2 was 3.53 % (+/- 0.38 %) at 1.5 Tesla and 3.25 % (+/- 0.61 %) at 3 Tesla. The mean regional reproducibility error for T2 was 8.62 % (+/- 2.61 %) at 1.5 Tesla and 9.66 % (+/- 3.37 %) at 3 Tesla. There was no significant difference with respect to absolute reproducibility errors between 1.5 Tesla and 3 Tesla at a constant spatial resolution. However, different reproducibility errors were found between the cartilage layers. One third of the data variability could be attributed to the influence of the different cartilage layers, and another 10 % to the influence of the separate MRI slices. CONCLUSION: Our data provides an estimation of the global and regional reproducibility errors of T2 in healthy cartilage. In the analysis of small subregions, an increase in the regional reproducibility error must be accepted. The data may serve as a basis for sample size calculations of study populations and may contribute to the decision regarding the level of detail of an evaluation of study data.
