ABSTRACT
The mean myeloperoxidase index (MPXI) is calculated during the routine complete blood count performed using the autoanalyzer ADVIA120/2120. The pattern of changes in the neutrophil myeloperoxidase levels in patients with specific infectious diseases was analyzed by assessing the MPXI levels. In patients with bacterial sepsis, identified by positive blood-culture tests, with (n = 29) and without (n = 51) systemic inflammatory response syndrome, the mean MPXI significantly reduced to -3.18 and -2.06, respectively. In contrast, among patients with nontuberculous nonseptic bacterial infections (n = 40), the mean MPXI significantly elevated to 5.51, while tuberculosis patients (n = 37) and patients with viral infection (n = 60) showed an unchanged MPXI (mean values, -0.46 and -1.06, respectively). Among the parameters of inflammation, only the C-reactive protein values showed a weak correlation with the MPXI levels. [Conclusion] These results indicate that MPXI is correlated with some specific infectious states, i.e. MPXI is low in bacterial sepsis and high in nontuberculous nonseptic bacterial infections. MPXI appears to be an independent and useful biomarker for the diagnosis and follow-up of infectious diseases, especially when the MPXI values are obtained at regular intervals during the disease courses of the patients.
Subject(s)
Bacterial Infections/enzymology , Neutrophils/enzymology , Peroxidase/blood , Adolescent , Adult , Bacterial Infections/blood , Biomarkers/blood , C-Reactive Protein/analysis , Child , Child, Preschool , Female , Humans , Infant , Infant, Newborn , Inflammation/enzymology , Male , Middle Aged , Sepsis/blood , Sepsis/enzymology , Tuberculosis/blood , Tuberculosis/enzymologyABSTRACT
Technetium 99m macroaggregated albumin (Tc-MAA) perfusion scintigraphy has been performed during hepatic arterial infusion chemotherapy using implantable reservoir. A total of 40 radionuclide (RI) studies were performed on 25 patients with liver metastasis of colorectal origin. Of 40 RI studies, 12 (30%) showed impaired liver perfusion. Three studies showed no perfusion of the liver, 3 increased radiotracer accumulations at liver hilus, 2 extrahepatic distributions, 2 catheter occlusions, 1 extravasation and 1 unilobar distribution. The accumulation of Tc-MAA in the tumor was graded from Grade I (tumor uptake decreased or similar relative to liver) to Grade III (tumor uptake remarkably increased). The response to chemotherapy was evaluable in 14 cases. A case with Grade I resulted in NC. Of 6 cases with Grade II, 1 resulted in MR, 3 in NC and 1 in PD. Of 8 cases with Grade III, 2 resulted in PR, 1 in MR and 5 in NC. Tumor response was observed in cases showing increased uptake of Tc-MAA. SPECT was performed in 7 cases, and revealed that hepatic tumors were hypervascular. We concluded that RI examination reveals not only hepatic perfusion, but also tumor microcirculation.
Subject(s)
Antineoplastic Agents/administration & dosage , Infusion Pumps, Implantable , Liver Neoplasms/drug therapy , Liver/diagnostic imaging , Colorectal Neoplasms/pathology , Humans , Infusions, Intra-Arterial , Liver Neoplasms/diagnostic imaging , Liver Neoplasms/secondary , Technetium Tc 99m Aggregated Albumin , Tomography, Emission-Computed, Single-PhotonABSTRACT
It was revealed by chance that the second FRC value measured by Chest Chestac 65V was significantly smaller than the first FRC value measured by Fukuda FRC Computer COMF-100 if the second repeated measurement in the same subjects was done shortly after the first FRC measurement with He closed-circuit method was performed. In order to clarify this phenomenon, the volumes of two different machines were accurately checked by a cylinder. No significant differences were found in the FRC values of two machines. In adult healthy subjects a small but significant difference between the first and the second ten minutes behind measurement was found even if the same machine was used. If FRC measurement was reexamined within a few minutes after the first one was done, much differences were found. Furthermore, diurnal variation of FRC values in the same subjects was also observed. FRC value in the morning was the highest.
Subject(s)
Circadian Rhythm , Functional Residual Capacity , Helium , Lung Volume Measurements , Adult , Female , Humans , Male , Methods , Middle Aged , Time FactorsABSTRACT
Permanent tracheostomy and tracheoesophageal anastomosis were performed as a means of surgical intervention for the treatment of intractable aspiration pneumonia. Conventional method of tracheoesophageal anastomosis has entailed various problems. The improved technique by the authors utilized the special histological features of the situation and makes possible safe and reliable anastomosis. This technique retains the tracheal perichondrium to strengthen the anastomosed portion of the trachea, and can thus prevent suture insufficiency due to tension upon the anastomotic site.
