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World J Biol Psychiatry ; 25(5): 283-290, 2024 06.
Article in English | MEDLINE | ID: mdl-38629762

ABSTRACT

OBJECTIVES: Molecular mechanisms of post-traumatic stress disorder (PTSD) development have been analysed by evaluati-ng changes in the expression level of long non-coding RNA (lncRNA) as a potential biomarker of the disease and as one of the molecular aspects associated with the disease development. METHODS: In our study, we used quantitative polymerase chain reaction (qPCR) to evaluate changes in the expression level of long non-coding RNA - Gomafu, NONMMUT033604.2, and NONMMUT064397.2 - in the hippocampus of mice that were subjected to an artificially induced middle single prolonged stress (mSPS) model of post-traumatic stress disorder. RESULTS: We found a significant reduction in the expression levels of each of the three lncRNAs tested: Gomafu in 45.4 times, NONMMUT033604.2 in 53.4 times, and NONMMUT064397.2 in 5.2 times. The results of the present study provide evidence that the mSPS model effectively induces PTSD-like behaviour in mice leading to a significant decrease in the expression level of Gomafu, NONMMUT033604.2 and NONMMUT064397.2 lncRNA in mice hippocampus. CONCLUSIONS: This data provides evidence that the three studied lncRNAs could be potential biomarkers of PTSD development.


Subject(s)
Disease Models, Animal , Down-Regulation , Hippocampus , RNA, Long Noncoding , Stress Disorders, Post-Traumatic , Animals , RNA, Long Noncoding/genetics , Hippocampus/metabolism , Stress Disorders, Post-Traumatic/genetics , Mice , Male , Stress, Psychological/genetics
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