Simultaneous Venous-Arterial Doppler Ultrasound During Early Fluid Resuscitation to Characterize a Novel Doppler Starling Curve: A Prospective Observational Pilot Study.

Background: The likelihood of a patient being preload responsive-a state where the cardiac output or stroke volume (SV) increases significantly in response to preload-depends on both cardiac filling and function. This relationship is described by the canonical Frank-Starling curve. Research Question: We hypothesize that a novel method for phenotyping hypoperfused patients (ie, the "Doppler Starling curve") using synchronously measured jugular venous Doppler as a marker of central venous pressure (CVP) and corrected flow time of the carotid artery (ccFT) as a surrogate for SV will refine the pretest probability of preload responsiveness/unresponsiveness. Study Design and Methods: We retrospectively analyzed a prospectively collected convenience sample of hypoperfused adult emergency department (ED) patients. Doppler measurements were obtained before and during a preload challenge using a wireless, wearable Doppler ultrasound system. Based on internal jugular and carotid artery Doppler surrogates of CVP and SV, respectively, we placed hemodynamic assessments into quadrants (Qx) prior to preload augmentation: low CVP with normal SV (Q1), high CVP and normal SV (Q2), low CVP and low SV (Q3) and high CVP and low SV (Q4). The proportion of preload responsive and unresponsive assessments in each quadrant was calculated based on the maximal change in ccFT (ccFTΔ) during either a passive leg raise or rapid fluid challenge. Results: We analyzed 41 patients (68 hemodynamic assessments) between February and April 2021. The prevalence of each phenotype was: 15 (22%) in Q1, 8 (12%) in Q2, 39 (57%) in Q3, and 6 (9%) in Q4. Preload unresponsiveness rates were: Q1, 20%; Q2, 50%; Q3, 33%, and Q4, 67%. Interpretation: Even fluid naïve ED patients with sonographic estimates of low CVP have high rates of fluid unresponsiveness, making dynamic testing valuable to prevent ineffective IVF administration.

Carotid Artery Corrected Flow Time Measured by Wearable Doppler Ultrasound Accurately Detects Changing Stroke Volume During the Passive Leg Raise in Ambulatory Volunteers.

BACKGROUND: The change in the corrected flow time of the common carotid artery (ccFTΔ) has been used as a surrogate of changing stroke volume (SVΔ) in the critically-ill. Thus, this relatively easy-to-obtain Doppler measure may help clinicians better define the intended effect of intravenous fluids. Yet the temporal evolution of SVΔ and ccFTΔ has not been reported in volunteers undergoing a passive leg raise (PLR). METHODS: We recruited clinically-euvolemic, non-fasted, adult, volunteers in a local physiology lab to perform 2 PLR maneuvers, each separated by a 5 minute 'wash-out'. During each PLR, SV was measured by a non-invasive pulse contour analysis device. SV was temporally-synchronized with a wireless, wearable Doppler ultrasound worn over the common carotid artery that continuously measured ccFT. RESULTS: 36 PLR maneuvers were obtained across 19 ambulatory volunteers. 8856 carotid Doppler cardiac cycles were analyzed. The ccFT increased nearly ubiquitously during the PLR and within 40-60 seconds of PLR onset; the rise in SV from the pulse contour device was more gradual. SVΔ by +5% and +10% were both detected by a +7% ccFTΔ with sensitivities, specificities and areas under the receiver operator curve of 59%, 95% and 0.77 (p < 0.001) and 66%, 76% and 0.73 (p < 0.001), respectively. CONCLUSIONS: The ccFTΔ during the PLR in ambulatory volunteers was rapid and sustained. Within the limits of precision for detecting a clinically-significant rise in SV by a non-invasive pulse contour analysis device, simultaneously-acquired ccFT from a wireless, wearable ultrasound system was accurate at detecting 'preload responsiveness'.

The Correlation between Carotid Artery Corrected Flow Time and Velocity Time Integral during Central Blood Volume Loss and Resuscitation.

Background: Doppler ultrasound of the common carotid artery is used to infer central hemodynamics. For example, change in the common carotid artery corrected flow time (ccFT) and velocity time integral (VTI) are proposed surrogates of changing stroke volume. However, conflicting data exist which may be due to inadequate beat sample size and measurement variability - both intrinsic to handheld systems. In this brief communication, we determined the correlation between changing ccFT and carotid VTI during progressively severe central blood volume loss and resuscitation. Methods: Measurements were obtained through a novel, wireless, wearable Doppler ultrasound system. Sixteen participants (ages of 18-40 years with no previous medical history) were studied across 25 lower body-negative pressure protocols. Relationships were assessed using repeated-measures correlation regression models. Results: In total, 33,110 cardiac cycles comprise this analysis; repeated-measures correlation showed a strong, linear relationship between ccFT and VTI. The strength of the ccFT-VTI relationship was dependent on the number of consecutively averaged cardiac cycles (R1 cycle = 0.70, R2 cycles = 0.74, and R10 cycles = 0.81). Conclusions: These results positively support future clinical investigations employing common carotid artery Doppler as a surrogate for central hemodynamics.

Síndrome de Mondor, relato de caso e revisão da literatura / Mondor's Disease, case report and literature review

A síndrome de Mondor é uma tromboflebite das veias superficiais da mama, que pode levar também ao comprometimento do sistema linfático. É uma doença benigna, rara e autolimitada. JMC, 42 anos, foi submetida à cirurgia de lipoaspiração e mastopexia, evoluindo bem no pós operatório imediato e recente. A paciente parou o uso de anticoncepcionais há 5 anos e havia realizado duas cesárias prévias. A lipoaspiração foi realizada em flancos e abdome, com vibrolipoaspirador microaire; técnica tumesceste. Na cirurgia mamária com pedículo inferior não areolado, foi feita ressecção mínima de parênquima mamário no lado E (70 gr) para simetrização. Tempo cirúrgico: 3 horas, deambulando algumas horas depois da cirurgia. Medicações pós operatórias incluiram antibiótico profilático e analgésicos, que o paciente recebeu no dia seguinte à cirurgia. Compareceu a todos os retornos de pós-operatório, sem nenhuma intercorrência. Realizou 30 sessões de drenagem linfática e ultrassom, ao longo de 3 meses, e retornou as suas atividades laborais após 30 dias. Por volta de 6 meses após os procedimentos, retornou com queixa de dor e endurecimento na porção superior de hemiabdome E. Ao exame físico foi identificado aparecimento de cordão endurecido, doloroso quando realizava extensão do abdome, caracterizando a sindome de Mondor. Foi instituido terapêutica de calor local e massagem associado a antiinflamatório via oral, havendo regressão do quadro após 1 mês. O tratamento da doença de Mondor é conservador e sintomático. Calor local, repouso e analgésicos ajudam a diminuir a dor, sinal clinico característico do cordão fibroso formado em decorrência do processo tromboflebítico.

Mondor 's syndrome is a thrombophlebitis of the superficial veins of the breast, which may also lead to impairment of the lymphatic system. It is a benign disease, rare and self-limited. JMC, 42 years old, was submitted to liposuction and breast lift, doing well in the immediate and late postoperative period. The patient stopped using contraceptives for 5 years and went trough two previous caesarians. Liposuction was performed on the flanks and abdomen, with Microaire Vibroliposuction Machine; tumescent technical. In the breast surgery with inferior pedicle not areolate, minimal resection of breast parenchyma was made on the left side (70 g) for symmetrization. Surgery time: 3 hours, ambulating a few hours after surgery. Postoperative medication included prophylactic antibiotics and analgesics, which patient received the next day after surgery. The patient attended all postoperative returns without any problem. 30 sessions of lymphatic drainage and ultrasound were made over 3 months, and the patient returned to work activities after 30 days. Six months after the procedure, the patient returned complaining of pain and hardening in the upper portion of left hemi-abdomen. In the physical examination was identified a hardened cord appearance, painful when performed extension of the abdomen, featuring Mondor ' s syndrome. Was instituted local heat therapy and massage associated with oral anti-inflammatory, with regression of the condition after one month. The treatment of Mondor 's disease is conservative and symptomatic. Local heat, rest and analgesics help to relief the pain, which is a clinical sign of fibrous cord formed as a result of thrombophlebitis process.

Pneumonia caused by Bordetella bronchiseptica in two HIV-positive patients / Pneumonia causada por Bordetella bronchiseptica em dois pacientes HIV-positivos

ABSTRACT: CONTEXT AND OBJECTIVE: Bordetella bronchiseptica (BB) is a Gram-negative coccobacillus responsible for respiratory diseases in dogs, cats and rabbits. Reports on its development in humans are rare. However, in immunosuppressed patients, especially in those with the immunodeficiency virus (HIV), BB can cause severe pulmonary infections. We report on two cases of pneumonia caused by BB in HIV-positive male patients in a university hospital. CASE REPORT: The first case comprised a 43-year-old patient who was admitted presenting chronic leg pain and coughing, with suspected pneumonia. BB was isolated from sputum culture and was successfully treated with trimethoprim/sulfamethoxazole in association with levofloxacin. The second case comprised a 49-year-old patient who was admitted presenting fever, nausea, sweating and a dry cough, also with suspected pneumonia. BB was isolated from sputum culture, tracheal secretions and bronchoalveolar lavage. The disease was treated with ciprofloxacin but the patient died. CONCLUSION: BB should be included in the etiology of pneumonia in immunodeficient HIV patients. As far as we know, these two were the first cases of pneumonia due to BB to occur in this university hospital.

RESUMO CONTEXTO E OBJETIVO: Bordetella bronchiseptica (BB) é um cocobacilo Gram-negativo responsável por causar doenças no trato respiratório de cães, gatos e coelhos. São raros os relatos do desenvolvimento desse microrganismo em seres humanos. Porém, em pacientes imunodeprimidos, especialmente nos portadores do vírus da imunodeficiência humana (HIV), a BB pode causar infecções pulmonares graves. Nós relatamos dois casos de pneumonia por BB em pacientes do sexo masculino, HIV-positivos em um hospital universitário. RELATO DE CASO: No primeiro caso, o paciente de 43 anos foi internado apresentando dor crônica nos membros inferiores e tosse com suspeita de pneumonia. Na cultura de escarro, foi isolado BB, e a infecção foi tratada com sucesso com a associação de sulfametoxazol/trimetroprima e levofloxacino. No segundo caso, o paciente de 49 anos foi internado apresentando febre, náuseas, sudorese e tosse seca, também com suspeita de pneumonia. Das culturas de escarro, secreção traqueal e lavado bronco-alveolar, foi isolado BB, infecção tratada com ciprofloxacino: porém, o paciente foi a óbito. CONCLUSÃO: BB deve ser incluído na etiologia de pneumonia em pacientes imunocomprometidos com HIV. Pelo que é de nosso conhecimento, estes dois relatos foram os primeiros casos de pneumonia por BB que ocorreram neste hospital universitário.

Pneumonia caused by Bordetella bronchiseptica in two HIV-positive patients.

CONTEXT AND OBJECTIVE: Bordetella bronchiseptica (BB) is a Gram-negative coccobacillus responsible for respiratory diseases in dogs, cats and rabbits. Reports on its development in humans are rare. However, in immunosuppressed patients, especially in those with the immunodeficiency virus (HIV), BB can cause severe pulmonary infections. We report on two cases of pneumonia caused by BB in HIV-positive male patients in a university hospital. CASE REPORT: The first case comprised a 43-year-old patient who was admitted presenting chronic leg pain and coughing, with suspected pneumonia. BB was isolated from sputum culture and was successfully treated with trimethoprim/sulfamethoxazole in association with levofloxacin. The second case comprised a 49-year-old patient who was admitted presenting fever, nausea, sweating and a dry cough, also with suspected pneumonia. BB was isolated from sputum culture, tracheal secretions and bronchoalveolar lavage. The disease was treated with ciprofloxacin but the patient died. CONCLUSION: BB should be included in the etiology of pneumonia in immunodeficient HIV patients. As far as we know, these two were the first cases of pneumonia due to BB to occur in this university hospital.

Blefaroplastia inferior com suporte cantal lateral / Lower eyelid blepharoplasty with lateral canthal support

INTRODUÇÃO: A abordagem transcutânea no rejuvenescimento palpebral inferior é uma técnica versátil e que permite amplo acesso a todas as estruturas periorbitárias. Apesar disso, muitos têm optado por outras vias de acesso, como a transconjuntival, devido ao risco aumentado de mal posicionamento palpebral. A utilização de suporte cantal lateral de rotina tem sido indicada sistematicamente para minimizar este risco. O presente trabalho revisou 136 casos operados com acesso transcutâneo e reforço cantal com cantopexia e suspensão orbicular. MÉTODO: Estudo retrospectivo de casos de blefaroplastia inferior primária transcutânea com cantopexia operados entre janeiro de 2008 e janeiro de 2014. Foram avaliados, por meio de fotos e registro de prontuários, a presença de dermatocalasio, bolsas palpebrais e flacidez tarsal. A técnica cirúrgica e o índice de complicações foram obtidos a partir da descrição cirúrgica e anotações clínicas. RESULTADOS: Foram operados 136 pacientes, com follow-up pós-operatório médio de 180 dias. Consideramos como complicações pós-operatórias epífora (15%), mal posicionamento palpebral (2,94%), hematoma orbital (0%), quemose (9,5%) e sensação de corpo estranho (6%). Sete pacientes (5,1%) precisaram de revisão cirúrgica. CONCLUSÃO: A realização de suporte cantal deveria ser considerada como parte integrante da blefaroplastia inferior transcutânea. Os autores acreditam que a cantopexia seja uma boa opção nos casos primários por sua fácil execução, baixa morbidade e eficácia comprovada na prevenção da esclera aparente, do arredondamento do canto lateral do olho e ectrópio.

INTRODUCTION: The transcutaneous approach in lower eyelid rejuvenation is a versatile technique allowing broad access to all periorbital structures. Nevertheless, many surgeons opt to use different access routes such as the transconjunctival approach, to avoid the increased risk of eyelid malposition. However, the use of a routine lateral canthal support was shown to consistently minimize this risk. This study reviewed 136 cases of patients who were operated on using the transcutaneous approach and canthal support with canthopexy and orbicularis suspension. METHOD: Our study used a retrospective design to investigate patients undergoing primary transcutaneous lower blepharoplasties performed with canthopexy, between January 2008 and January 2014. We assessed the presence of dermatochalasis, eyelid bags and tarsal sagging by analyzing patients' images and medical records. We used surgical descriptions and clinical notes to study the surgical technique used and the rate of complications associated with the same. RESULTS: Our study involved monitoring the post-operative condition of 136 patients for approximately 180 days after they underwent surgery. The occurrence of any of the following was considered a postoperative complication: epiphora (15%), eyelid malposition (2.94%), orbital hematoma (0%), chemosis (9.5%), and foreign body sensation (6%). Seven patients (5.1%) required surgical revision. CONCLUSION: Our assessment revealed that canthal support must be considered as an integral part of transcutaneous lower blepharoplasty. The authors believe that canthopexy is a good option in primary cases owing to its easy implementation, low morbidity, and efficacy in preventing apparent sclera, round eye lateral corner, and ectropion.