ABSTRACT
BACKGROUND: Clinical and epidemiologic features of coronary heart disease may not be explained solely by established risk factors. The role of infectious pathogens in the development and rupture of atherosclerotic plaques remains elusive but an association between Chlamydia pneumoniae, Mycoplasma pneumoniae and CHD has been reported previously. OBJECTIVES: To determine whether there is an association between mycoplasmal infections and CHD. METHODS: We conducted a prospective cohort analysis of 150 consecutive hospitalized patients with CHD (85 with acute coronary syndrome and 65 admitted for unrelated reasons) and 98 healthy blood donors. Antibody titers for Mycoplasma pneumoniae, M. fermentans, M. hominis and Ureaplasma urealyticum were measured with the agglutination test or specific enzyme-linked immunosorbent assay in all three groups of patients. RESULTS: Analysis of the antibody titers did not reveal any significant difference in the presence of mycoplasmal antibodies between the patients with ACS, patients with known stable CHD hospitalized for non-CHD reasons, and healthy blood donors. CONCLUSIONS: Determination of specific antibodies did not reveal a significant association among different types of mycoplasmal infection and CHD.
Subject(s)
Antibodies, Bacterial/blood , Coronary Disease/immunology , Mycoplasma/immunology , Acute Coronary Syndrome/immunology , Agglutination Tests , Coronary Disease/etiology , Enzyme-Linked Immunosorbent Assay , Female , Humans , Male , Middle Aged , Mycoplasma Infections/complications , Mycoplasma fermentans/immunology , Mycoplasma hominis/immunology , Mycoplasma pneumoniae/immunology , Prospective Studies , Ureaplasma urealyticum/immunologySubject(s)
Antibodies, Monoclonal/therapeutic use , Antirheumatic Agents/therapeutic use , Arthritis, Rheumatoid/drug therapy , Tuberculosis/diagnosis , Tumor Necrosis Factor-alpha/antagonists & inhibitors , Arthritis, Rheumatoid/complications , Female , Humans , Infliximab , Middle Aged , Tuberculosis/complications , Tuberculosis/etiologyABSTRACT
Acne can be associated with severe musculoskeletal and constitutional symptoms. This is a case history of a 15 year-old boy with severe acne, treated with isotretinoin, who was admitted because of high fever and weight loss of 3 weeks duration. His complaints were of severe chest and back pain, and inability to walk. His laboratory results revealed elevated erythrocyte sedimentation rate and C-reactive protein. On a pelvic radiograph bilateral sacroiliitis was noticed. Radionuclide bone scan revealed increased uptake in the right sacroiliac joint, in small vertebral bodies and sternum. A diagnosis of acne-associated musculoskeletal syndrome was made and the patient was treated with high dose steroids. His symptoms resolved and his acne improved. This case report sheds light on the relationship between acne and associated musculoskeletal syndromes. Physicians should be aware of this association in order to provide prompt and efficient treatment.
Subject(s)
Acne Vulgaris/complications , Musculoskeletal Diseases/etiology , Adolescent , Blood Sedimentation , C-Reactive Protein/metabolism , Dermatologic Agents/therapeutic use , Humans , Isotretinoin/therapeutic use , Male , Musculoskeletal Diseases/drug therapy , SyndromeABSTRACT
Popliteal cyst rupture is a known phenomenon following strenuous labor or sport activity. We present a case in which popliteal cyst rupture followed an unusual strenuous physical activity--devoted prayer during the holy month of the Ramadan.
Subject(s)
Physical Exertion , Popliteal Cyst/complications , Rupture/etiology , Humans , Islam , Israel , Male , Middle AgedABSTRACT
Mycoplasma have been shown to be involved in the alteration of several eukaryotic cell functions, such as cytokine production, gene expression and more. We have previously reported that infection of human myelomonocytic U937 cell line with live Mycoplasma fermentans (M. fermentans) inhibited tumour necrosis factor (TNF-alpha)-induced apoptosis. Mycoplasmal membrane lipoproteins are considered to be the most potent initiators of inflammatory reactions in mycoplasmal infections. The aim of this study was to clarify whether the inhibitory effect on TNFalpha-induced apoptosis is exerted by M. fermentans lipoproteins (LPMf). A significant reduction in TNFalpha-induced apoptosis was demonstrated by stimulation of U937 cells with M. fermentans total proteins, LPMf or MALP-2 (M. fermentans synthetic lipopeptide), but not with M. fermentans hydrophilic protein preparation (AqMf). To investigate the mechanism of M. fermentans antiapoptotic effect, the reduction of mitochondrial transmembrane potential (delta psi m) was measured. M. fermentans total proteins LPMf and MALP-2, but not AqMf, inhibited the reduction of delta psi m. In addition, M. fermentans total proteins LPMf and MALP-2, but not AqMf, downregulated the formation of active caspase-8. NF-kappaB was transactivated in cells treated with M. fermentans lipoproteins, and was essential for host cell survival, but not for the inhibition of TNFalpha-induced apoptosis by LPMf. Our results suggest that the inhibitory effect exerted by M. fermentans on TNFalpha-induced apoptosis in U937 cells is due to the membrane lipoproteins of these bacteria.
Subject(s)
Apoptosis , Bacterial Proteins/metabolism , Lipoproteins/metabolism , Mycoplasma fermentans/chemistry , Tumor Necrosis Factor-alpha/metabolism , Caspase 8/metabolism , Humans , Lipopeptides , Membrane Potential, Mitochondrial , Membrane Proteins/metabolism , Mycoplasma fermentans/cytology , NF-kappa B/metabolism , Oligopeptides/metabolism , U937 CellsABSTRACT
A 48-year-old woman presented with acute coronary syndrome and underwent coronary angiography which revealed myocardial bridging at the distal end of the left anterior descending artery with otherwise normal coronary arteries. The patient used to take ergotamine for her chronic migraine. Possible association with myocardial bridging which was found in this patient is discussed.
