Subject(s)
Enteral Nutrition/methods , Gastroscopy/methods , Adult , Aged , Enteral Nutrition/instrumentation , Female , Humans , Male , Middle AgedABSTRACT
Immunohistologic studies were performed to evaluate the expression and regional distribution of 20 colorectal carcinoma-associated antigens in the colonic mucosa of 12 normal adults. A distinct regional variation was seen in the expression of blood group A, B, Lewis(b), and extended Lewis(y) antigens, which were expressed predominantly in the right colon, whereas Lewis(a), Lewis(y), and H-type 2 were prevalent throughout. Lewis(x) and X-like antigens were only occasionally expressed. Two antibodies against sialylated Lewis(a) showed different staining patterns, with CA19.9 positive in only two biopsies and CO29.11 intensely positive in most. Two of the three antibodies detecting carcinoembryonic antigen epitopes (3d6 and COL-4) stained many biopsies, whereas COL-12 was rarely detected. No regional gradient was found in the expression of the other antigens studied (B72.3, ME491; GA73.3, ND1, and ND4). This mapping data will provide an important baseline for future studies of epitope distribution in the colon in premalignant and neoplastic conditions.
Subject(s)
Antigens, Neoplasm/immunology , Colorectal Neoplasms/immunology , Intestinal Mucosa/immunology , ABO Blood-Group System/immunology , Adult , Aged , Antigens, Differentiation/immunology , Antigens, Neoplasm/analysis , Biomarkers, Tumor/analysis , Carcinoembryonic Antigen/immunology , Epitopes , Female , Humans , Immunohistochemistry , Isoantigens/immunology , Male , Middle Aged , Reference ValuesABSTRACT
This case report documents extensive gastrointestinal cytomegalovirus infection in a patient with acquired immunodeficiency syndrome, presenting as diarrhea and involving stomach, duodenum, and colon. Endoscopic biopsy specimens and cultures were essential to make the diagnosis and to distinguish the illness from inflammatory bowel disease. A careful search for other potential pathogens was made as well. The discussion includes a review of literature regarding cytomegalovirus involvement of the gastrointestinal tract.
Subject(s)
Acquired Immunodeficiency Syndrome/complications , Colitis/complications , Cytomegalovirus Infections/complications , Adult , Antibodies, Monoclonal/immunology , Colitis/microbiology , Cytomegalovirus/isolation & purification , Homosexuality , Humans , Lung/microbiology , Male , T-Lymphocytes/immunologyABSTRACT
A patient with recurrent upper gastrointestinal bleeding after having a "C"-shaped mesocaval shunt created is reported. During endoscopic examination, the graft was seen to have eroded into the duodenal lumen. This rare complication of mesocaval shunts may become more common with the increaseing use of "C"-shaped grafts.
Subject(s)
Duodenum/pathology , Esophageal and Gastric Varices/surgery , Postoperative Complications/surgery , Duodenum/surgery , Esophagoscopy , Gastrointestinal Hemorrhage/surgery , Humans , Male , Middle Aged , Portasystemic Shunt, Surgical/adverse effects , Splenorenal Shunt, Surgical/adverse effects , Venae Cavae/surgeryABSTRACT
This report describes a middle-aged female who received imipramine for 7 days, developed severe cholestatic jaundice with features similar to primary biliary cirrhosis, and then improved clinically over the next 12 mo. Biochemical and histologic abnormalities persisted over a 14-yr period of follow-up, though subsequent administration of haloperidol may have influenced the long-term course. High levels of circulating immune complexes were also found 14 yr later, which raises questions about the relationship of primary biliary cirrhosis to drug-induced liver injury. A review of the literature on imipramine- and phenothiazine-related hepatic injuries reveals multiple similarities, and this case provides further evidence for a common hepatic reaction to the two drugs.
