ABSTRACT
In a double-blind, dose comparison multicenter trial 115 patients with duodenal ulcer were treated with either 20 or 30 mg oral omeprazole once daily for 4 weeks. There was no difference in the healing rates for the two groups after 2 and 4 weeks. After 2 weeks with 20 and 30 mg healing frequencies were 79.0 and 72.7%, after 4 weeks 96.5 and 92.7%. No difference was observed between the groups in the number of pain episodes during day and night. No side effects to the drug occurred. A daily dose of 20 mg omeprazole may be effective in ulcer therapy.
Subject(s)
Benzimidazoles/administration & dosage , Duodenal Ulcer/drug therapy , Adult , Benzimidazoles/therapeutic use , Clinical Trials as Topic , Female , Humans , Male , Middle Aged , Omeprazole , Time Factors , Wound HealingABSTRACT
We studied a 71-year-old patient with sinusbradycardia due to ingestion of food. He had a history of two syncopes at lunch. Mechanical irritation of the esophagus close to the atrium as well as insufflation of air into the stomach caused bradycardia with a heart rate of 28 per minute. Bradycardia could be suppressed with atropin given intravenously. There were no abnormal roentgenographic and pathological findings regarding the esophagus and the stomach.