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1.

Birbeck granules (Langerhans' cell granules) in human lymph nodes.

Vernon, M L; Fountain, L; Krebs, H M; Horta-Barbosa, L; Fuccillo, D A; Sever, J L.

Am J Clin Pathol ; 60(6): 771-9, 1973 Dec.

Article in English | MEDLINE | ID: mdl-4758275

Subject(s)

Histiocytes , Langerhans Cells , Lymph Nodes/pathology , Colitis, Ulcerative/pathology , Diseases in Twins , Humans , Inguinal Canal , Lymph Nodes/cytology , Microscopy, Electron , Mitochondria , Multiple Sclerosis/pathology , Subacute Sclerosing Panencephalitis/pathology

2.

Viral investigations in ulcerative colitis and regional enteritis.

Farmer, G W; Vincent, M M; Fuccillo, D A; Horta-Barbosa, L; Ritman, S; Sever, J L; Gitnick, G L.

Gastroenterology ; 65(1): 8-18, 1973 Jul.

Article in English | MEDLINE | ID: mdl-4352745

Subject(s)

Antibodies, Viral , Colitis, Ulcerative/microbiology , Crohn Disease/microbiology , Cytomegalovirus/immunology , Antibody Formation , Biopsy , Colitis, Ulcerative/immunology , Complement Fixation Tests , Corticosterone/adverse effects , Crohn Disease/immunology , Culture Techniques , Cytomegalovirus/isolation & purification , Cytopathogenic Effect, Viral , Female , Fluorescent Antibody Technique , Humans , Male , Microscopy, Electron , Virus Cultivation

3.

Herpes simplex encephalitis in an anergic patient.

Price, R; Chernik, N L; Horta-Barbosa, L; Posner, J B.

Am J Med ; 54(2): 222-8, 1973 Feb.

Article in English | MEDLINE | ID: mdl-4685847

Subject(s)

Encephalitis/immunology , Herpes Simplex/immunology , Hodgkin Disease/complications , Immunosuppression Therapy/adverse effects , Adult , Autopsy , Biopsy , Cytarabine/therapeutic use , Encephalitis/drug therapy , Encephalitis/etiology , Encephalitis/pathology , Frontal Lobe/pathology , Herpes Simplex/drug therapy , Herpes Simplex/etiology , Humans , Male , Parietal Lobe/pathology

4.

Epidemiology of subacute sclerosing panencephalitis (SSPE). A report of the SSPE registry.

Jabbour, J T; Duenas, D A; Sever, J L; Krebs, H M; Horta-Barbosa, L.

JAMA ; 220(7): 959-62, 1972 May 15.

Article in English | MEDLINE | ID: mdl-4554467

Subject(s)

Subacute Sclerosing Panencephalitis/epidemiology , Adolescent , Adult , Age Factors , Antibodies/analysis , Brain/microbiology , Child , Child, Preschool , Female , Fluorescent Antibody Technique , Humans , Infant , Lymph Nodes/microbiology , Male , Measles/complications , Measles virus/isolation & purification , Registries , Sex Factors , Subacute Sclerosing Panencephalitis/etiology , Subacute Sclerosing Panencephalitis/physiopathology , Time Factors , United States

5.

Progressive multifocal leukoencephalopathy.

Horta-Barbosa, L; Hamilton, R; Fucillo, D A; Hogan, D; Sever, J L; Gerin, J.

N Engl J Med ; 286(19): 1060, 1972 May 11.

Article in English | MEDLINE | ID: mdl-4622718

Subject(s)

Demyelinating Diseases/microbiology , Brain/microbiology , Humans , Leukoencephalopathy, Progressive Multifocal/microbiology , Viruses/isolation & purification

6.

Subacute encephalitis and hypogammaglobulinemia.

Hanissian, A S; Jabbour, J T; DeLamerens, S; Garcia, J H; Horta-Barbosa, L.

Am J Dis Child ; 123(2): 151-5, 1972 Feb.

Article in English | MEDLINE | ID: mdl-4554550

Subject(s)

Agammaglobulinemia/complications , Encephalitis/complications , Agammaglobulinemia/pathology , Biopsy , Blood Proteins/analysis , Brain/pathology , Child, Preschool , Encephalitis/pathology , Fluorescent Antibody Technique , Humans , Immunoglobulins/analysis , Male

7.

Diagnosis of subacute sclerosing panencephalitis by a simple spinal fluid gel precipitation test for measles.

Dietzman, D E; Horta-Barbosa, L; Krebs, H M; Madden, D L; Fuccillo, D A; Sever, J L.

Pediatrics ; 49(1): 133-6, 1972 Jan.

Article in English | MEDLINE | ID: mdl-4621769

Subject(s)

Antibodies/cerebrospinal fluid , Measles/immunology , Subacute Sclerosing Panencephalitis/cerebrospinal fluid , Subacute Sclerosing Panencephalitis/diagnosis , Antibody Formation , Humans , Immunodiffusion , Methods , Subacute Sclerosing Panencephalitis/immunology

8.

Chronic viral infections of the central nervous system.

Horta-Barbosa, L; Fuccillo, D A; Sever, J L.

JAMA ; 218(8): 1185-8, 1971 Nov 22.

Article in English | MEDLINE | ID: mdl-4940819

Subject(s)

Central Nervous System Diseases/etiology , Virus Diseases/complications , Aleutian Mink Disease , Amyotrophic Lateral Sclerosis/etiology , Animals , Brain Diseases/veterinary , Central Nervous System Diseases/veterinary , Chronic Disease , Creutzfeldt-Jakob Syndrome/etiology , Dementia/etiology , Enterovirus B, Human/isolation & purification , Humans , Kuru/etiology , Leukoencephalopathy, Progressive Multifocal/etiology , Lymphocytic Choriomeningitis/veterinary , Measles virus/isolation & purification , Mink , Multiple Sclerosis/etiology , Papillomaviridae/isolation & purification , Parkinson Disease/etiology , Polyomaviridae , Polyradiculopathy/etiology , Scrapie , Sheep , Subacute Sclerosing Panencephalitis/etiology , Virus Diseases/veterinary

9.

Subacute sclerosing panencephalitis: isolation of suppressed measles virus from lymph node biopsies.

Horta-Barbosa, L; Hamilton, R; Wittig, B; Fuccillo, D A; Sever, J L; Vernon, M L.

Science ; 173(3999): 840-1, 1971 Aug 27.

Article in English | MEDLINE | ID: mdl-4937231

ABSTRACT

Measles virus was isolated in mixed cultures of lymph node cells and HeLa cells. The agent was isolated by cocultivation from biopsy specimens of two of five patients with subacute sclerosing panencephalitis. The virus was identified by hemagglutination-inhibition, immunofluorescent, and neutralization tests. Biopsies from controls did not show evidence of measles virus.

Subject(s)

Lymph Nodes/microbiology , Measles virus/isolation & purification , Subacute Sclerosing Panencephalitis/microbiology , Adolescent , Biopsy , Child , Female , Fluorescent Antibody Technique , HeLa Cells , Hemagglutination Inhibition Tests , Humans , Male , Neutralization Tests , Virus Cultivation

10.

Progressive increase in cerebrospinal fluid measles antibody levels in subacute sclerosing panencephalitis.

Horta-Barbosa, L; Krebs, H; Ley, A; Chen, T C; Gilkeson, M R; Sever, J L.

Pediatrics ; 47(4): 782-3, 1971 Apr.

Article in English | MEDLINE | ID: mdl-5089768

Subject(s)

Antibodies/analysis , Measles virus , Subacute Sclerosing Panencephalitis/cerebrospinal fluid , Complement Fixation Tests , Hemagglutination Inhibition Tests , Humans , Subacute Sclerosing Panencephalitis/blood , Subacute Sclerosing Panencephalitis/diagnosis , Subacute Sclerosing Panencephalitis/immunology

11.

Recent observations in Jakob-Creutzfeldt disease.

Watanabe, I; Kolar, O; Horta-Barbosa, L; Fucillo, D; Sever, J L; Thopson, J; Zeman, W.

J Neuropathol Exp Neurol ; 30(1): 123-4, 1971 Jan.

Article in English | MEDLINE | ID: mdl-4925305

Subject(s)

Central Nervous System Diseases/pathology , Blood Protein Electrophoresis , Creutzfeldt-Jakob Syndrome/blood , Creutzfeldt-Jakob Syndrome/cerebrospinal fluid , Creutzfeldt-Jakob Syndrome/pathology , Humans

12.

Virus-like particles and nucleoprotein-type filaments in brain tissue from two patients with Creutzfeldt-Jakob disease.

Vernon, M L; Horta-Barbosa, L; Fuccillo, D A; Sever, J L; Baringer, J R; Birnbaum, G.

Lancet ; 1(7654): 964-6, 1970 May 09.

Article in English | MEDLINE | ID: mdl-4191933

Subject(s)

Brain Chemistry , Brain/microbiology , Central Nervous System Diseases , Nucleoproteins/analysis , Viruses/isolation & purification , Adult , Aged , Creutzfeldt-Jakob Syndrome/etiology , Creutzfeldt-Jakob Syndrome/microbiology , Cytoplasm/analysis , Extracellular Space/analysis , Female , Humans , Male , Microscopy, Electron

13.

Some characteristics of SSPE measles virus.

Horta-Barbosa, L; Fuccillo, D A; Hamilton, R; Traub, R; Ley, A; Sever, J L.

Proc Soc Exp Biol Med ; 134(1): 17-21, 1970 May.

Article in English | MEDLINE | ID: mdl-5423500

Subject(s)

Diffuse Cerebral Sclerosis of Schilder/microbiology , Measles virus/immunology , Amnion/cytology , Animals , Chick Embryo , Complement Fixation Tests , Culture Techniques , Cytopathogenic Effect, Viral , Dogs , Hemagglutination Inhibition Tests , Hemagglutination Tests , Humans , Kidney/cytology , Measles virus/isolation & purification

14.

Isolation of measles virus from brain cell cultures of two patients with subacute sclerosing panencephalitis.

Horta-Barbosa, L; Fuccillo, D A; London, W T; Jabbour, J T; Zeman, W; Sever, J L.

Proc Soc Exp Biol Med ; 132(1): 272-7, 1969 Oct.

Article in English | MEDLINE | ID: mdl-4981174

Subject(s)

Brain/microbiology , Diffuse Cerebral Sclerosis of Schilder/microbiology , Measles virus/isolation & purification , Animals , Child , Culture Techniques , Cytopathogenic Effect, Viral , Fluorescent Antibody Technique , Haplorhini , HeLa Cells , Hemadsorption Inhibition Tests , Hemagglutination Inhibition Tests , Hemagglutination, Viral , Humans , Measles virus/immunology

15.

Serological tests for rubella.

Newman, S; Horta-Barbosa, L; Sever, J L.

Lancet ; 2(7617): 432, 1969 Aug 23.

Article in English | MEDLINE | ID: mdl-4184508

Subject(s)

Immunoglobulin G/analysis , Immunoglobulin M/analysis , Rubella/immunology , Blood , Centrifugation, Density Gradient , Hemagglutination Inhibition Tests , Humans , Infant, Newborn , Infant, Newborn, Diseases/immunology , Methods , Sucrose , Ultracentrifugation , Umbilical Cord

16.

Comparative sensitivity of tissue cultures to rubella virus: use of guinea pig cells for virus titration.

Horta-Barbosa, L; Warren, J.

Appl Microbiol ; 18(2): 251-5, 1969 Aug.

Article in English | MEDLINE | ID: mdl-4979943

ABSTRACT

A series of 19 different primary and serial tissue cultures were investigated for their sensitivity to virulent or attenuated rubella virus (RV). Primary guinea pig tissues, a serial passage of baby hamster kidney, and primary human amnion were comparable to African green monkey kidney tissue cultures in their sensitivity. In general, primary human tissues were relatively insusceptible to the Gilchrist strain of RV. RV interfered with the growth of vesicular stomatitis virus. Based on this finding, it was possible to develop an assay method in guinea pig tissue cultures by using VSV as the challenge virus. This system appeared to be comparable in sensitivity to the use of primary monkey kidney tissue cultures for the detection of small amounts of RV and offers the advantages of economy, rapidity, and safety.

Subject(s)

Culture Techniques , Rubella virus/isolation & purification , Virus Cultivation , Animals , Bone Marrow , Carnivora , Cell Line , Cornea , Cricetinae , Embryo, Mammalian , Guinea Pigs , Haplorhini , Humans , Kidney , Lung , Mice , Rabbits , Spleen , Swine , Thymus Gland , Thyroid Gland

17.

Subacute sclerosing panencephalitis.

Fuccillo, D A; Horta-Barbosa, L; Sever, J L.

Lancet ; 1(7605): 1101, 1969 May 31.

Article in English | MEDLINE | ID: mdl-4181767

Subject(s)

Encephalitis/microbiology , Measles virus/isolation & purification , Brain/microbiology , Fluorescent Antibody Technique , Humans , Thymus Gland/microbiology

18.

Subacute sclerosing panencephalitis: isolation of measles virus from a brain biopsy.

Horta-Barbosa, L; Fuccillo, D A; Sever, J L; Zeman, W.

Nature ; 221(5184): 974, 1969 Mar 08.

Article in English | MEDLINE | ID: mdl-5765518

Subject(s)

Brain/microbiology , Diffuse Cerebral Sclerosis of Schilder/etiology , Measles virus/isolation & purification , Biopsy , Child , Humans

19.

Rubella virus.

Horta-Barbosa, L; Fuccillio, D; Sever, J L.

Curr Top Microbiol Immunol ; 47: 69-81, 1969.

Article in English | MEDLINE | ID: mdl-5774846

Subject(s)

Rubella virus , Rubella/prevention & control , Abnormalities, Multiple , Animals , Female , Humans , Infant, Newborn , Models, Biological , Rodentia , Vaccines

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