ABSTRACT
Testicular tumors of germ cell origin are extremely rare in rats. We encountered 2 cases of teratoma and embryonal carcinoma in the testes of 8- and 10-week-old Sprague-Dawley IGS rats. A unilateral tumor mass with bilateral testicular atrophy was observed macroscopically in both cases. Microscopic examination revealed that the tumor mass had characteristic features of a teratoma and was composed of several types of differentiated cells and tissues at various stages of maturation. Embryonal carcinoma tissue, composed of undifferentiated cells with an embryonic and anaplastic appearance, was observed within the tumor mass. In addition, foci of intratubular teratomas and embryonal carcinomas were observed in the testis on the side without any obvious mass. No obvious germ cells were observed in the seminiferous tubules in the remnant nontumorous area. Furthermore, intratubular transition of cells was observed from the embryonal carcinoma tissue to the squamous epithelium. This finding indicates that an embryonal carcinoma differentiates toward a teratoma even at a very early stage of development of the germ cell tumor.
Subject(s)
Carcinoma, Embryonal/veterinary , Neoplasms, Multiple Primary/veterinary , Rats, Sprague-Dawley , Rodent Diseases/pathology , Teratoma/veterinary , Testicular Neoplasms/veterinary , Animals , Carcinoma, Embryonal/pathology , Male , Neoplasms, Multiple Primary/pathology , Rats , Teratoma/pathology , Testicular Neoplasms/pathologySubject(s)
Genitalia, Female/growth & development , Sexual Maturation , Aging , Animals , Cell Count , Endometrium/growth & development , Epithelial Cells/cytology , Epithelium/growth & development , Estradiol/blood , Female , Mitotic Index , Muscle Development , Myometrium/growth & development , Organ Size , Ovary/growth & development , Pregnancy , Rats , Uterus/growth & development , Vagina/growth & developmentABSTRACT
A total of 113 specimens collected from purulent skin lesions of household cats was examined bacteriologically. Ninety seven isolates obtained from 74 specimens (65.5%). Of these, 11 specimens (9.7%) contained obligate anaerobes only, 18 specimens (15.9%) yielded both obligate and facultative anaerobes. In the obligate anaerobes detected, genus Fusobacterium was the most frequently observed and F. nucleatum was most common species. Pasteurella multocida was the facultative anaerobe which was most frequently detected.
Subject(s)
Abscess/veterinary , Bacteria, Anaerobic/isolation & purification , Cat Diseases , Skin Diseases, Bacterial/veterinary , Abscess/microbiology , Actinomyces/isolation & purification , Animals , Bacteria, Anaerobic/classification , Bacteroides/isolation & purification , Cats , Clostridium/isolation & purification , Enterobacteriaceae/isolation & purification , Enterococcus/isolation & purification , Fusobacterium/isolation & purification , Pasteurella/isolation & purification , Skin Diseases, Bacterial/microbiology , Staphylococcus/isolation & purification , Streptococcus/isolation & purificationABSTRACT
Pasteurella multocida was isolated from 21 of 105 purulent skin lesions in household cats. The bacterium was in pure culture in nine specimens and predominant in six specimens. Its viable counts were 10(2) to 10(7) colony forming units/ml. Of 21 isolates of P. multocida, seventeen were considered to be capsular type A. The predominant capsular and somatic type was the serotype A:3,4. Inoculation of the filter-sterilized supernatants of the isolates induced an erythematous response in guinea pig skins. These findings suggest that P. multocida is a candidate as a pathogen of feline skin lesions and the erythema-inducing activity of the bacterium may participate in the formation of skin lesions in household cats.
