Volumetric fibular transfer planning with shape-based indicators in mandibular reconstruction.

In preoperative planning for mandibular reconstructive surgery, it is necessary to determine the osteotomy lines for fibular shaping and the proper placement of fibular segments in the mandible. Although virtual surgical planning has been utilized in preoperative decision making, current software designs require manual operation and a trial-and-error process to refine the reconstruction plan. We have developed volumetric fibular transfer simulation software that can quickly design a preoperative plan based on direct volume manipulation and quantitative comparison with the patient's original mandible. We propose three quantitative shape indicators-volume ratio, contour error, and maximum projection-for symmetrical lesions of the mandible, and have implemented a parallel computation algorithm for the semiautomatic placement of fibular segments. Using this virtual planning software, we conducted a retrospective study of the computed tomography data from nine patients. We found that combining direct volume manipulation with real-time local search of placement improved the applicability of the planning system to optimize mandibular reconstruction.

Volumetric surgical planning system for fibular transfer in mandibular reconstruction.

This presentation introduces a new software design for virtual preoperative planning for free fibular transfer in mandibular reconstructive surgery. Direct volume resection and manipulation of superimposed fibular segments allow interactive editing of the surgical plan without the need for a surface modeling process. We also introduce three shape indicators: volume ratio, contour error and maximum projection for evaluating the reconstruction plan from geometrical aspects. The indicators significantly quantify the difference between 2-segment and 3-segment cases, and suggest optimization of preoperative planning while satisfying appropriate placement margins for fibular segments.

Toxicity of agricultural chemicals in Daphnia magna.

BACKGROUND: Daphnia magna is a useful aquatic organism for testing ecological toxicities of environmental pollutants. However, there were only a few studies on agricultural chemicals using these organisms. METHODS: We investigated acute and subchronic toxicities of 30 agricultural chemicals commonly used in Japan in D. magna. Acute toxicity of the agricultural chemicals was determined using the concentrations yielding 50% immobility of D. magna after 24 hr and 48 hr exposure as end points. D. magna was cultivated with the chemical and algae until the first brood production. Lethal toxicity and the number of survival broods were determined within 13 days. RESULTS: All insecticides among the agricultural chemicals exhibited the strongest acute toxicity (LC50 from 0.00053 to 0.037 mg/L). More than 50% of the herbicides and fungicides did not exhibit acute toxicity at 10 mg/L. Chlornitrofen, pencycuron, and fenitrothion showed significantly lower LC50 values at 8 days than at 24 hr and 48 hr. Isoprothiolane, flutolanil, and thiophanatemethyl significantly delayed the first brood at concentrations less than half of those for LC50 (8 days). Thiobencarb, iprodione, flutolanil, mepronil, and thiophanatemethyl significantly reduced the size of the first brood at concentrations less than half of those for LC50 (8 days). CONCLUSIONS: In this study, chlornitrofen, pencycuron, and fenitrothion were suggested to have slow-acting toxicity. Also, thiobencarb, iprodione, flutolanil, mepronil, and thiophanatemethyl were suggested to have parthenogenetic toxicity.