ABSTRACT
Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in infancy and childhood. Approximately 20 % of patients with JIA suffer from the polyarticular form of the disease, which causes a substantial disease burden and long-term sequelae. Therapeutic approaches have used steroids and conventional disease modifying antirheumatic drugs (DMARD) but over the last decade new drugs have become available for the treatment of JIA, in particular biologic DMARD. This article summarizes the current therapy options for polyarticular JIA.
Subject(s)
Antibodies, Monoclonal/administration & dosage , Antirheumatic Agents/administration & dosage , Arthritis, Juvenile/drug therapy , Arthritis, Juvenile/prevention & control , Arthritis/drug therapy , Biological Products/administration & dosage , Steroids/administration & dosage , Arthritis/diagnosis , Arthritis/prevention & control , Arthritis, Juvenile/diagnosis , Child , Child, Preschool , Drug Design , Evidence-Based Medicine , Humans , Immunotherapy/trends , Infant , Infant, Newborn , Treatment OutcomeABSTRACT
Innovative developments in the pharmacotherapy of juvenile idiopathic arthritis and especially biologics allow the formulation of new therapeutic targets, such as the rapid induction of remission with shortening of the period of active disease and therefore preventing damage and disability. These new therapies also represent a challenge to the monitoring of drug safety, the pharmacovigilance. For this purpose the Society for Paediatric and Adolescent Rheumatology has set up an early register to record achievements in treatment improvement and in addition to independently assess information on drug safety, acute tolerance and long-term safety.
Subject(s)
Antibodies, Monoclonal/therapeutic use , Arthritis, Juvenile/drug therapy , Arthritis, Juvenile/epidemiology , Biological Products/therapeutic use , Drug-Related Side Effects and Adverse Reactions/epidemiology , Registries/statistics & numerical data , Adolescent , Child , Child, Preschool , Comorbidity , Female , Germany , Humans , Infant , Infant, Newborn , Male , Prevalence , Risk Assessment , Treatment OutcomeABSTRACT
Acute otitis media is one of the most common infections in childhood and the options of therapy have been examined in numerous studies. Nevertheless, there are controversial opinions regarding the question whether antibiotic therapy makes sense. This is proved through the many different ways that the primary treatment of the middle ear infection is handled throughout the international community. This work gives an overview of the current knowledge and based on these results gives practical recommendations to assist with the diagnosis and treatment of the individual patients.
