ABSTRACT
BACKGROUND: Childhood obesity increases cardiovascular risk during adulthood. Retinol-binding protein-4, a pro-inflammatory adipokine, associated with obesity and insulin resistance also plays a role in atherogenesis in adults. The goal of this study was to identify the relation between RBP4 and atherogenic markers in obese children. METHODS: In a cross-sectional study, obese and non-obese children (8-18 years) were prospectively recruited from a pediatric Appalachian population. Clinical markers such as lipid profile, HbA1c, markers of insulin resistance and plasma levels of RBP4, sVCAM-1 and oxidized-low-density lipoprotein (Ox-LDL) were measured. RESULTS: Compared to non-obese children, RBP4 (P=0.016) and Ox-LDL (P<0.001) were significantly higher in obese children and were positively correlated with Body Mass Index (P<0.001), BMI-SDS (Standard-Deviation Score) (P<0.001) and waist circumference (P=0.03). CONCLUSIONS: No significant correlation was found between inflammatory markers and Homeostatic Model Assessment-2, HDL, triglycerides, and HbA1c in obese children.
Subject(s)
Atherosclerosis/blood , Pediatric Obesity/blood , Retinol-Binding Proteins, Plasma/analysis , Adolescent , Atherosclerosis/complications , Biomarkers/blood , Body Mass Index , Child , Cross-Sectional Studies , Female , Humans , Lipoproteins, LDL/blood , Male , Pediatric Obesity/complications , PubertyABSTRACT
Ezetimibe is a lipid-lowering agent that inhibits the intestinal absorption of cholesterol and other related phytosterols. It is used alone or in combination with other lipid-lowering agents in the treatment of various forms of hypercholesterolemia. Since its FDA approval in 2002, there are no known citations of ezetimibe-induced pancreatitis.
Subject(s)
Anticholesteremic Agents/adverse effects , Azetidines/adverse effects , Pancreatitis, Acute Necrotizing/chemically induced , Anticholesteremic Agents/therapeutic use , Azetidines/therapeutic use , Diagnosis, Differential , Dyslipidemias/drug therapy , Ezetimibe , Female , Follow-Up Studies , Humans , Lipase/blood , Middle Aged , Pancreatitis, Acute Necrotizing/diagnosis , Pancreatitis, Acute Necrotizing/enzymologyABSTRACT
We report a case of Crohn's disease that was associated with marked dermatologic manifestations depicting necrotizing vasculitis around the ankles. On further evaluation, this patient was found to have aortic narrowing, which fit the criteria for Takayasu's arteritis.
