Subject(s)
Akinetic Mutism/etiology , Hydrocephalus/surgery , Parkinson Disease/etiology , Ventriculoperitoneal Shunt/adverse effects , Akinetic Mutism/diagnosis , Akinetic Mutism/therapy , Antiparkinson Agents/therapeutic use , Bromocriptine/therapeutic use , Child , Female , Humans , Parkinson Disease/diagnosis , Parkinson Disease/therapy , Physical Therapy Modalities , Treatment OutcomeABSTRACT
BACKGROUND AND PURPOSE: Intramedullary spinal cord tumors (IMSCT) are relatively rare neoplasms, accounting for less than 5% of all central nervous system tumors. The optimum management of these tumors still remains controversial. Many decades ago, partial surgical resection followed by radiotherapy was the conventional management for IMSCT. Nowadays, maximal surgical resection of IMSCT without adjuvant therapy is the rule. We discuss the management of our cohort of 45 patients and review retrospectively the surgical outcome and survival. METHODS AND RESULTS: We reviewed the charts of 45 patients who underwent surgery for IMSCT in our institution since 1990. The study included 23 female and 22 male with a mean age of 28.7 years (range: 18 months-64 years). In 40 patients, the final diagnosis was based on the results of MR imaging. The cervical location of the tumor was the most common (20 cases). Surgical procedures included a gross-total resection in 31 cases, subtotal resection in six cases, partial resection in five cases and a biopsy in three cases. The large majority of patients had histologically-proven low-grade tumors composed essentially of astrocytomas (44,4%) and ependymomas (28,8%). There was no mortality related to surgery. Concerning the functional outcome at six months, we noted that 22.2% of our patients deteriorated, 47.3% stayed the same and 30.5% improved. We found that patients with mild or no preoperative deficits were exceptionally damaged by the surgical procedure. CONCLUSIONS: The gold-standard treatment of IMSCT remains maximal microsurgical resection without adjuvant therapy. For malignant or rapidly recurrent IMSCT, the optimum management is still controversial. Determinant predictors for a good outcome after surgery of IMSCT are histological type of lesion, total removal of the tumor and a satisfactory neurological status before surgery.
Subject(s)
Spinal Cord Neoplasms/surgery , Adolescent , Adult , Biopsy , Child , Child, Preschool , Disease Progression , Female , Humans , Infant , Magnetic Resonance Imaging , Male , Microsurgery , Middle Aged , Spinal Cord/pathology , Spinal Cord Neoplasms/pathology , Treatment OutcomeABSTRACT
Extraneural diffusion of glioblastoma is very unusual. Extracranial metastases generally occur after craniotomy or a long survival time. Metastases usually involve the lungs, pleura, lymph nodes and occasionally the bone. We report herein a case of bone dissemination occurring 18 month after the initial diagnosis and treatment of supratentorial glioblastoma.
Subject(s)
Glioblastoma/secondary , Spinal Neoplasms/secondary , Supratentorial Neoplasms/pathology , Thoracic Vertebrae , Adult , Humans , MaleSubject(s)
Hyperlipoproteinemia Type II , Aortic Valve Stenosis/diagnosis , Aortic Valve Stenosis/etiology , Aortic Valve Stenosis/surgery , Child , Coronary Disease/diagnosis , Coronary Disease/etiology , Echocardiography, Doppler , Electrocardiography , Female , Humans , Hyperlipoproteinemia Type II/complications , Hyperlipoproteinemia Type II/genetics , Hypertrophy, Left Ventricular/diagnosis , Hypertrophy, Left Ventricular/etiology , Mitral Valve Insufficiency/diagnosis , Mitral Valve Insufficiency/etiology , Mitral Valve Insufficiency/surgeryABSTRACT
Thyroglossal duct cyst, a common clinical entity, may undergo malignant change. The majority of such malignancies are capillary adenocarcinomas; squamous cell carcinomas are rare. Only 7 cases have been reported since 1950. The authors present a case of a 65 years old man who died 16 months after the tumor's discovery.
