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Bioorg Med Chem
; 20(22): 6613-20, 2012 Nov 15.
Article
in English
| MEDLINE
| ID: mdl-23063517
ABSTRACT
The 4-isoxazolyl-dihydropyridines (IDHPs) exhibit inhibition of the multidrug-resistance transporter (MDR-1), and exhibit an SAR distinct from their activity at voltage gated calcium channels (VGCC). Among the four most active IDHPs, three were branched at C-5 of the isoxazole, including the most active analog, 1k.