ABSTRACT
The effect of long-term intoxication of cadmium (administered subcutaneously in a dose of 1 mg Cd/kg of body weight once a week for one month) on the absorption of water, sodium, potassium, glucose, glycine and thiamine in the small intestine of rats was investigated. In addition, the influence of cernitins (special pollen extract) on the action of cadmium intoxication was tested. The cernitins were given by stomach pump in the form of an aqueous solution of Pollitabs Sport tablets in a dose of 1.5 mg of cernitin T-60 and 0.075 mg of cernitin GBX per individual twice a week for two weeks or four weeks according to the group of animals tested. The results indicated that long-term administration of cadmium increased the intestinal absorption of all tested substances. Meanwhile, the application of cernitins reduced the effects of cadmium intoxication upon intestinal absorption and the processes of absorption was close to normal.
Subject(s)
Cadmium/pharmacology , Intestinal Absorption/drug effects , Intestine, Small/metabolism , Plant Extracts , Pollen , Animals , Glucose/metabolism , Glycine/metabolism , Intestine, Small/drug effects , Male , Potassium/metabolism , Rats , Rats, Inbred Strains , Reference Values , Secale , Sodium/metabolism , Thiamine/metabolismABSTRACT
The effects of bile and digestive juices was studied on the intestinal absorption of water, sodium and glucose in the small intestine of rats after their intoxication with one dose of cadmium 1.33 mg/kg of body weight injected intravenously. The investigations were carried out on 60 rats by the method of intestinal perfusion. The obtained results showed that cadmium inhibited the intestinal absorption of these substances. Bile and digestive juices abolished partially this effect during their physiological secretion. After administration of cholagogues no protective role of bile and digestive juices was observed alleviating the toxic effects of cadmium, and the intestinal absorption was even more reduced.
