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Characterization of a multicopper oxidase gene from Staphylococcus aureus.
Sitthisak, S; Howieson, K; Amezola, C; Jayaswal, R K.
Appl Environ Microbiol ; 71(9): 5650-3, 2005 Sep.
Article in English | MEDLINE | ID: mdl-16151171

ABSTRACT

A multicopper oxidase gene from Staphylococcus aureus was cloned and overexpressed. Purified recombinant multicopper oxidase oxidized the substrate 3,3'-dimethoxybenzidine in the presence of copper. Disruption of mco showed copper sensitivity and H(2)O(2) resistance, suggesting roles for mco in copper homeostasis and oxidative stress response. Northern blot analysis showed copper-induced mco transcription.


Subject(s)
Copper/metabolism , Gene Expression Regulation, Bacterial , Oxidoreductases/genetics , Staphylococcus aureus/enzymology , Cloning, Molecular , Copper/pharmacology , Dianisidine/metabolism , Heat-Shock Response , Hydrogen Peroxide/pharmacology , Molecular Sequence Data , Oxidation-Reduction , Oxidative Stress , Oxidoreductases/metabolism , Sequence Analysis, DNA , Staphylococcus aureus/drug effects , Staphylococcus aureus/genetics , Staphylococcus aureus/physiology
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