ABSTRACT
AIM: The analysis of the available reported data and epidemiological investigation data on the cases of Creutzfeld-Jakob disease (CJD) that emerged in the Nový Jicín district in 2001-2011, with a focus on the familial form of the disease. MATERIAL AND METHODS: Data from the Regional Public Health Service of the Moravian-Silesian Region, local Public Health Centre Nový Jicín, were used for the analysis. RESULTS: This is a retrospective report of 10 cases of familial Creutzfeld-Jakob disease (CJD) in the Nový Jicín district in 2001-2011, based on the data from the public health service. Overall eight cases were notified and seven suspected cases were identified retrospectively. Out of these 15 cases, five were concluded to be sporadic CJD and 10 to be familial CJD. The PRNP D178N mutation was found in two fatal cases from 2002 and 2003. Genetic investigation of their relatives was not performed for ethical reasons. CONCLUSION: The high incidence of familial CJD in the Nový Jicín district in 2001-2011 is surprising, but the retrospective investigation failed to provide further evidence to understand this outbreak.
Subject(s)
Creutzfeldt-Jakob Syndrome , Czech Republic , Humans , Retrospective StudiesABSTRACT
Legionella was discovered in the first half of the 20th century. The main representative of the genus is the bacterial species Legionella pneumophila. Legionella can cause a mild disease with fever but also severe to fatal pneumonia. At highest risk are individuals with an underlying disease, immunosuppressed patients or individuals exposed to other risk factors (e.g. users of addictive substances). Information on the etiology and epidemiology of legionellosis is presented. Selected risk factors are described as well as preventive measures to be taken in water supply and cooling systems. In conclusion, emphasis is placed on the prevention.
Subject(s)
Legionella/physiology , Legionellosis/epidemiology , Czech Republic/epidemiology , Humans , Legionella/genetics , Legionella/isolation & purification , Legionellosis/microbiology , Risk FactorsSubject(s)
Antimalarials/therapeutic use , Malaria/drug therapy , Quinolines/therapeutic use , Adolescent , Animals , Female , Humans , Mefloquine , Plasmodium falciparumABSTRACT
Investigation for Toxoplasma gondii infection using complement fixation test and microprecipitation method in agar gel was performed in fifteen patients with clinically and morphologically typical hairy-cell leukemia. Positive complement fixation test was found in four patients. In three patients an initially high complement fixation titer or its considerable increase associated with positive microprecipitation in agar gel suggested a recent toxoplasmosis. The importance of search for Toxoplasma gondii infection in hairy-cell leukemia patients especially before splenectomy and the necessity of reinvestigation after splenectomy is stressed.
