[Use of contact lenses during general anesthesia]. / Uzití kontaktních cocek u celkových anestézií.

In 1987-8 the authors investigated changes of the cornea in patients during prolonged operations under general anaesthesia in IMV Brno. They analyzed the causes of corneal damage during prolonged unconsciousness and assessed the relationship of cornea changes on the decrease of lacrimation, change of BUT and period of unconsciousness during general anaesthesia. For the protection of the cornea of anaesthetized patients soft contact lenses were used and the sequelae of their application were compared with the application of other hitherto used protective devices (covering the cornea by an occlusion bandage, viscous drops eye jelly or eye ointment). Hydrophil contact lenses proved useful as a satisfactory protective device to cover the cornea during long-term anaesthesia.

[Beta 2-microglobulin and tumors of the central nervous system]. / Beta 2-mikroglobulin a nádory centrální nervové soustavy.

In 60 patients with tumours of the central nervous system (50 intracranial, 10 intraspinal) the beta 2-microglobulin in serum and cerebrospinal fluid was examined. The frequency of pathological finding was in both examined fluids considerable and differed with regard to the type and site of the tumours; it was particularly high in intracranial gliomas (in serum 87.1%, in cerebrospinal fluid 74.2%). For comparison a group of 55 patients with multiple sclerosis was examined where the incidence of elevated beta 2-microglobulin was markedly lower (in serum 29.1%, in cerebrospinal fluid 20%). Normal values in serum and cerebrospinal fluid were obtained in 50 subjects without organic lesions of the nervous system.

[The significance of isoelectric focusing of unconcentrated cerebrospinal fluid in the detection of oligoclonal zones in multiple sclerosis]. / Význam izoelektrické fokusace nekoncentrovaného mozkomísního moku v detekci oligoklonálních pruhu u sclerosis multiplex.

In a group of 31 patients with a confirmed diagnosis of multiple sclerosis the authors assessed the presence of oligoclonal abnormality of gammaglobulins in cerebrospinal fluid. Specimens of non-concentrated cerebrospinal fluid were examined by two separating methods which use as a vehicle polycryamide gel: isoelectric focusing and a modified electrophoretic technique. By isoelectric focusing an oligoclonal state was proved in 71%, the finding was doubtful in 16.1% and negative in 12.9%. The applied electrophoretic separation revealed an oligoclonal state in 58.1%, the finding was doubtful in 25.8%, negative in 16.1%. In cerebrospinal fluid where isoelectric focusing did not prove an oligoclonal finding, the latter was not detected by electrophoresis either. The method of isoelectric focusing is obviously more sensitive than mere electrophoretic separation. In common practice, it is, however, better to use electrophoresis in vehicles which positively influence the separation process, best in a polyacrylamide gel. Only when the finding is negative or doubtful and there is urgentclinical suspicion, it is suitable to supplement the examination by isoelectric focusing.

[Indicators of the incidence of cerebrovascular disorders in a selected part of the Brno agglomeration]. / Nekteré ukazatele výskytu cerebrovaskulárních onemocnení ve vymezené cásti brnenské aglomerace.

In a retrospective survey the annual incidence of cerebrovascular diseases was assessed in the Faculty Hospital the catchment area of which comprises the major portion of the Brno agglomeration. The number of patients with cerebrovascular diseases who received treatment in 1986 was 486. This corresponds to 0.17% and to 170 patients per 100,000 population. From the above number of patients 329 suffered from a first attack of the disease, i.e. 0.12% or 115 cases per 100,000. The age, sex, tape of attack, mortality social distribution and risk factors are evaluated.