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Eur Neurol ; 68(1): 23-7, 2012.
Article in English | MEDLINE | ID: mdl-22677920

ABSTRACT

AIM: To determine whether corpus callosum atrophy predicts future clinical deterioration in multiple sclerosis. METHODS: In 39 multiple sclerosis patients the area of corpus callosum in the sagittal plane, T2 and T1 lesion volumes, brain parenchymal fraction and brain atrophy were determined at baseline and 1 year after treatment initiation. Non-parametric and multiple regression models were built to identify the most reliable predictors of disability and of its changes over 9 years. RESULTS: Corpus callosum atrophy during the first year of treatment was the best predictor of disability (r = -0.56) and of its increase at 9 years (r = 0.65). Corpus callosum atrophy of at least 2% predicted increase in disability with 93% sensitivity and 73% specificity (odds ratio = 35). CONCLUSION: Corpus callosum atrophy is a simple and accurate predictor of future disability accumulation and is feasible for routine clinical practice.


Subject(s)
Corpus Callosum/pathology , Multiple Sclerosis, Relapsing-Remitting/pathology , Adult , Atrophy/pathology , Disease Progression , Female , Humans , Longitudinal Studies , Magnetic Resonance Imaging , Male , Retrospective Studies , Sensitivity and Specificity
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