ABSTRACT
It is found that 3 months after removal of thyroid gland in rats, a suppression of thymic endocrine function, loss of weight and cellularity occurs. These changes are mainly caused by a weakening of index of proliferative activity. In animals that postoperatively received substitutive thyroxin hormonotherapy and courses of thymulin these disorders don't occur or they are not expressed significantly.
Subject(s)
Apoptosis/drug effects , Hormone Replacement Therapy , Thymus Gland/drug effects , Thymus Hormones/pharmacology , Thyroidectomy , Thyroxine/pharmacology , Animals , Body Weight/drug effects , Cell Proliferation/drug effects , Male , Organ Size/drug effects , Rats , Thymus Gland/pathology , Thymus Hormones/therapeutic use , Thyroxine/therapeutic useABSTRACT
The effect of thymalin on peroxidation of lipids in thyroidectomized rats that received thyroxin at a dose 2 mg/ kg was examined. It was found that 3 months after operation a decrease in body weight (over 2 times), weight of spleen and amount of cells in it took place. An increase of TB-activated products in livers and spleens of thyroidectomized rats 3 month later was not essential. Indices of enzyme activity of antioxidant system in liver were within normal ranges while indices of activity of catalase and superoxidedysmuthase in spleen increased by 4,3 and 1,3 times, respectively. Simultaneous administration of thyroxin and thymalin promotes more effective normalization of POL peroxidation, inhibits development of pathologic changes in organism after removal of thyroid gland.
Subject(s)
Antioxidants/metabolism , Catalase/metabolism , Hormone Replacement Therapy/methods , Lipid Peroxides/metabolism , Superoxide Dismutase/metabolism , Thyroidectomy , Animals , Body Weight/drug effects , Drug Therapy, Combination , Liver/drug effects , Liver/enzymology , Liver/metabolism , Male , Organ Size/drug effects , Rats , Rats, Wistar , Spleen/drug effects , Spleen/enzymology , Spleen/metabolism , Thymus Hormones/administration & dosage , Thymus Hormones/therapeutic use , Thyroxine/administration & dosage , Thyroxine/therapeutic useABSTRACT
Due to disorders of hormonal balance in the organism, a decrease in thymic endocrine function occurred in rats after thyroidectomy. After removing the thyroid gland, we observed 1,3-2,2-fold decrease in the level of thymic hormone thymulin in the blood serum. When thyroxin was applied at a suppressive dose, endocrine function of the thymus did not restore. Injections of thymostimulin (Tp1) or its combination with thyroxin to thyroidectomized animals restored the level of thymulin up to the level in the intact rats due to effects of either injected preparation or induction of substances possessing thymosine-like activity.
Subject(s)
Adjuvants, Immunologic/therapeutic use , Thymic Factor, Circulating , Thymus Extracts/therapeutic use , Thymus Gland/metabolism , Thyroidectomy , Thyroxine/therapeutic use , Animals , Drug Therapy, Combination , Male , Rats , Thymic Factor, Circulating/administration & dosage , Thymic Factor, Circulating/drug effects , Thymic Factor, Circulating/metabolism , Thymic Factor, Circulating/therapeutic use , Thymus Gland/drug effects , Thymus Gland/immunology , Thyroid Hormones/blood , Thyroxine/administration & dosage , Thyroxine/bloodABSTRACT
In the livers and spleens of pseudoectomized, thymectomized, thymthyroidectomized mice and thyroidectomized rats there is clear regularity in the change of lipid peroxidation intensity antioxidant system and enzymes activity depending on the severity and duration of pathologic changes occurred in organism and biological significance of the removed endocrine glands in maintenance of homeostasis. Thymostimulin and thyroxin do not render a direct effect on the intensity of lipid peroxidation, but their injection to the thyroidectomized rats indirectly normalizes content of peroxidant products in tissues of liver and spleen and restores disordered metabolism processes as a result of thyroid gland ectomia.
Subject(s)
Antioxidants/metabolism , Glycoproteins/pharmacology , Lipid Peroxidation/drug effects , Thyroxine/pharmacology , Animals , Catalase/metabolism , Liver/drug effects , Liver/metabolism , Mice , Mice, Inbred CBA , Oxidation-Reduction , Rats , Spleen/drug effects , Spleen/metabolism , Superoxide Dismutase/metabolism , Thymectomy , ThyroidectomyABSTRACT
Application of nonspecific active immunotherapy in the treatment of 59 radically operated patients with pulmonary cancer had permitted in brief period of time to restore quantitative and functional indexes of cellular link of immunity, had promoted noncomplicated course of postoperative period, the reduction of the postoperative complications frequency and improvement of late follow-up results of surgical treatment of the patients in the absence of metastases in regional lymphatic nodes.
