Quantum synchronization of conjugated variables in a superconducting device leads to the fundamental resistance quantization.

We propose a way to achieve quantum synchronization of two canonically conjugated variables. For this, we employ a superconducting device where the synchronization of Josephson and Bloch oscillations results in the quantization of transresistance similar to that in the (fractional) quantum Hall effect. An LC oscillator is a key component to achieve an exponentially small rate of synchronization errors.

Model of a proposed superconducting phase slip oscillator: a method for obtaining few-photon nonlinearities.

We theoretically investigate a driven oscillator with the superconducting inductance subject to quantum phase slips (QPS). We find uncommon nonlinearities in the proposed device: they oscillate as a function of the number of photons N with a local period of the order of √N. We prove that such nonlinearities result in multiple metastable states encompassing few photons and study oscillatory dependence of various responses of the oscillator. Such nonlinearities enable new possibilities for quantum manipulation of photon states and very sensitive measurements to confirm the coherence of phase slips.

[The reaction of 3-(R-phenyl)-6-hydrazine pyridazines with substituted isatins (II)]. / La réaction de certaines 3-(R-phényle)-6-hydrazino-pyridazines avec des isatines substituées (II).

This paper presents the synthesis of six hydrazones from isatin and 1-morpholinomethyl-isatin and also of their six cooper's complex salts. Their structure was confirmed by the results of the quantitative elemental analysis and by IR, UV-VIS spectral analysis. The biological tests point out that cooper's complex salt of 3-(3'-phenyl-pyridazinylhydrazono)-5-methyl-indoline-2-one (1:2) (VI a) has the smallest toxicity (DMT over 800 mg/kg.w. p.o.), a remarkable anti-inflammatory activity (inhibition 57.1%, IAR 1.1) and also a gastroprotector coefficient of 43.3%. In the mean time, the cooper's complex salt of 3-(3'-p-anisyl-pyridazinyl-hydrazono)-5-methyl-ind oline-2-one (1:2) (VI b) has a gastroprotector coefficient of 76.3% and a lower anti-inflammatory activity than the first derivative (inhibition 36.9%).

Prolonged gastroprotective activity of a ranitidine-dextran conjugate.

The paper presents the influence of the ranitidine-dextran conjugate on the gastric secretion stimulated with carbachol on rats with a ligated pylorus [correction of ligaturated pilor]. The gastric lesions, the gastric juice volume and the total acidity at 6, 24 and 48 hours after the treatment were examined. Ranitidine serum content was determined by HPLC. Administration of the ranitidine-dextran conjugate produces a higher inhibition of gastric lesions at 48 hours than the administration of the free drug (61.4% versus 33.9%) and a prolonged action for more 48 hours. Synthesis of a macromolecular prodrug of ranitidine and its in vitro behavior was reported in a previous paper (11). The present paper studies the performances obtained in gastro-protective action by using the new ranitidine-dextran conjugate reported (11).

[The reaction of 3-(R-phenyl)-6-hydrazine pyridazine with 5-methylisatin and 1-morpholinomethyl-5-methylisatin]. / La réaction de la 3-(R-phényle)-6-hydrazino-pyridazine avec la 5-méthyl-isatine et la 1-morpholinométhyl-5-méthyl-isatine.

This paper presents the synthesis of six hydrazones obtained by treating 5-methyl-isatin or 1-morpholino methyl-5-methyl-isatin with 3-(R-phenyl)-6-hydrazino-pyridazine (R = OCH3, Cl, Br) and two complex combination with copper, derived from 3-(p-anisyl-pyridazinyl)-hydrazone-5-methyl-indoline-2- one. The structure of the new compounds was confirmed by the results of the quantitative elementary and IR, UV-VIS spectral analysis. The biological tests point out that product VI, in which a copper atom binds two molecules of 3-(p-anisyl-pyridazinyl)-hydrazono-5-methyl-indoline-2-one, has a considerable antiinflammatory activity, giving a inflammation inhibition of 39, 6%. All the synthetized compounds have a moderate antimicrobial activity against Candida albicans.

[Do calcium antagonists potentiate analgesia?]. / Antagonistii calciului potenteaza analgezia?

Studying the analgesic action for some of the calcium antagonists (nifedipin and verapamil) we found for the middle therapeutic doses analgesic effect of similar intensity with the middle therapeutic doses for aspirin and paracetamol. While associating these substances, we obtained an enhanced analgesic effect from 50% for the substances when taken separately to 65-88% when associating calcium antagonists with analgesic and antipyretics. This interaction on the analgesic effect could be explained by the common intervention of the two groups of substances on the physiological link between prostaglandins and calcium.

Experimental studies on the dynamics of the scaring effect of some ointments.

The ointment studied is made by us in the laboratory. He includes the following ingredients: a bee-keeping product soved in sunflower oil, an antioxidant, hexestrole, and a proper preserving medium. The idea was to create a product which is capable to accelerate the scarring process of the plague produced by burns. Thus, after 10-12 days we can observe a favourable clinical evolution. Anatomo-microscopy is obvious a gradually regenerating epithelium and the subjacent dermis remains slightly infiltrated. The final result is an aesthetic scar.

[The study of resorcin eyedrops]. / Contributii la studiul picaturilor pentru ochi cu rezorcina.

Seven resorcin eye drop formulas using various physico-chemical stabilizers, acid buffer solutions, antioxidants such as sodium pyrosulphite, cysteine and keodants such as EDTA--Na were prepared. A parallelism between the physico-chemical stability and local biological tolerance in rabbit eyes was found, fact demonstrating that the occurrence of some oxidation products are responsible for the biological intolerance manifestations. A pH under 5 is favourable to resorcin stability and local biological tolerance to resorcin eye drops.

[A pharmacodynamic investigation of the effect of polyholozidic substances extracted from Plantago sp. on the digestive tract]. / Investigarea farmacodinamica a influentei substantelor poliholozidice extrase din Plantago sp. asupra tractului digestiv.

From the leaves and seeds of some Plantago species (Plantago major, media, lanceolata) the polyholozidic fraction was separated. A statistically significant gastroprotective action was found both in the case of the polyholozide obtained from seeds and leaves in two experimental models. At higher doses a laxative action was also obtained.