1.
J Med Chem
; 30(4): 678-82, 1987 Apr.
Article
in English
| MEDLINE
| ID: mdl-3494124
ABSTRACT
The synthesis of tenoxicam, 4-hydroxy-2-methyl-N-2-pyridyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxami de 1,1-dioxide (1e), and of the analogues with various residues on the ring nitrogen and the amide nitrogen is described. This new class of "oxicams" has pronounced antiinflammatory and analgesic properties. The very specific structure-activity relationship of isomeric and isosteric groups at the amide nitrogen has been evaluated. The substituent in position 2 also has a great influence on the pharmacological properties. Tenoxicam is presently undergoing clinical trials.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis , Piroxicam/analogs & derivatives , Animals , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Anti-Inflammatory Agents, Non-Steroidal/toxicity , Edema/drug therapy , Piroxicam/chemical synthesis , Piroxicam/therapeutic use , Piroxicam/toxicity , Rats , Stomach Ulcer/chemically induced , Structure-Activity Relationship
2.
Arch Pharm (Weinheim)
; 313(7): 636-44, 1980 Jul.
Article
in German
| MEDLINE
| ID: mdl-7190816
3.
Arch Pharm (Weinheim)
; 313(7): 587-602, 1980 Jul.
Article
in German
| MEDLINE
| ID: mdl-7406668