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1.
Zhonghua Zhong Liu Za Zhi ; 40(1): 52-56, 2018 Jan 23.
Article in Chinese | MEDLINE | ID: mdl-29365418

ABSTRACT

Objective: To verify the safety and efficacy of IONTRIS particle therapy system (IONTRIS) in clinical implementation. Methods: Between 6.2014 and 8.2014, a total of 35 patients were enrolled into this trial: 31 males and 4 females with a median age of 69 yrs (range 39-80). Ten patients had locally recurrent head and neck tumors after surgery, 4 cases with thoracic malignancies, 1 case with hepatocellular carcinoma, 1 case with retroperitoneal sarcoma, and 19 cases with non-metastatic prostate carcinomas. Phantom dose verification was mandatory for each field before the start of radiation. Results: Twenty-two patients received carbon ion and 13 had proton irradiation. With a median follow-up time of 1 year, all patients were alive. Among the 16 patients with head and neck, thoracic, and abdominal/pelvic tumors, 2, 1, 12, and 1 cases developed complete response, partial response, stable disease, or disease progression, respectively. Progression-free survival rate was 93.8% (15/16). Among the 19 patients with prostate cancer, biological-recurrence free survival was 100%. Particle therapy was well tolerated in all 35 patients. Twenty-five patients (71.4%) experienced 33 grade 1 acute adverse effects, which subsided at 1 year follow-up. Six (17.1%) patients developed grade 1 late adverse effects. No significant change in ECOG or body weight was observed. Conclusions: IONTRIS is safe and effective for clinical use. However, long term follow-up is needed to observe the late toxicity and long term result.


Subject(s)
Head and Neck Neoplasms/radiotherapy , Heavy Ion Radiotherapy/methods , Prostatic Neoplasms/radiotherapy , Proton Therapy/methods , Retroperitoneal Neoplasms/radiotherapy , Sarcoma/radiotherapy , Adult , Aged , Aged, 80 and over , Disease-Free Survival , Female , Head and Neck Neoplasms/pathology , Heavy Ion Radiotherapy/adverse effects , Humans , Male , Middle Aged , Prostatic Neoplasms/pathology , Proton Therapy/adverse effects , Retroperitoneal Neoplasms/pathology , Sarcoma/pathology
2.
Physiol Res ; 59(5): 821-829, 2010.
Article in English | MEDLINE | ID: mdl-20406032

ABSTRACT

Sleep is regulated by complex biological systems and environmental influences, neither of which is fully clarified. This study demonstrates differential effects of partial sleep deprivation (SD) on sleep architecture and psychomotor vigilance task (PVT) performance using two different protocols (sequentially) that each restricted daily sleep to 3 hours in healthy adult men. The protocols differed only in the period of sleep restriction; in one, sleep was restricted to a 3-hour block from 12:00 AM to 3:00 AM, and in the other, sleep was restricted to a block from 3:00 AM to 6:00 AM. Subjects in the earlier sleep restriction period showed a significantly lower percentage of rapid-eye-movement (REM) sleep after 4 days (17.0 vs. 25.7 %) and a longer latency to the onset of REM sleep (L-REM) after 1 day (78.8 vs. 45.5 min) than they did in the later sleep restriction period. Reaction times on PVT performance were also better (i.e. shorter) in the earlier SR period on day 4 (249.8 vs. 272 ms). These data support the view that earlier-night sleep may be more beneficial for daytime vigilance than later-night sleep. The study also showed that cumulative declines in daytime vigilance resulted from loss of total sleep time, rather than from specific stages, and underscored the reversibility of SR effects with greater amounts of sleep.


Subject(s)
Arousal/physiology , Psychomotor Performance/physiology , Sleep Deprivation/physiopathology , Sleep, REM/physiology , Circadian Rhythm/physiology , Humans , Male , Polysomnography , Reaction Time/physiology , Young Adult
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