ABSTRACT
OBJECTIVE: The aim of the study was to identify risk factors for mortality in patients brought to the emergency department (ED) after blunt traumatic brain injury (TBI). METHODS: The medical records of such patients who visited the ED from June 2004 to May 2005 were retrospectively reviewed. Data (age, gender, initial Glasgow coma scale (GCS) scores, initial vital signs, brain computed tomography scan findings and cause of trauma) were collected from the records of 204 TBI patients, who were treated at the ED and needed intensive care. Among these patients, 48 died in the intensive care unit (ICU) of the hospital. Logistic regression was used to assess factors affecting mortality after trauma. RESULTS: Age (odds ratio (OR) 1.04; 95% CI 1.01 to approximately 1.07), GCS score less than 9 (OR 19.29; 95% CI 5.04 to approximately 73.82) and skull bone fracture (OR 10.44; 95% CI 3.59 to approximately 30.38) were identified as possible risk factors of mortality in TBI patients. CONCLUSION: These predictors appear to be clinically relevant and may help improve ED triage of TBI patients in need of ICU care.
Subject(s)
Brain Injuries/mortality , Emergency Service, Hospital , Skull Fractures/mortality , Wounds, Nonpenetrating/mortality , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , Brain Injuries/complications , Epidemiologic Methods , Female , Glasgow Coma Scale , Humans , Injury Severity Score , Male , Middle Aged , Prognosis , Risk Factors , Skull Fractures/complications , Wounds, Nonpenetrating/complications , Young AdultABSTRACT
OBJECTIVE: The aims of this retrospective study were to investigate whether the quantification of ovarian stromal blood flow and/or leptin concentration are predictive of in vitro fertilization (IVF) outcomes in women after laparoscopic ovarian cystectomy for large endometriomas. METHODS: Twenty-two women undergoing IVF after laparoscopic surgery for ovarian endometriomas (> 6 cm) comprised the study group. Twenty-six women with tubal factor infertility constituted the control group. Ovarian stromal blood flow was evaluated by three-dimensional (3D) power Doppler ultrasound imaging using virtual organ computer-aided analysis (VOCAL( trade mark )). Serum and follicular fluid (FF) leptin concentrations were quantified using an enzyme-linked immunosorbent assay kit. RESULTS: There were significantly decreased ovarian stromal blood flow parameters (including vascularization index, flow index (FI), and vascularization flow index) in the endometriosis group without an evident difference in total ovarian volume on the day of human chorionic gonadotropin. The value of FF leptin demonstrated a negative correlation with ovarian stromal FI in the control group, but there was a loss of this effect in the endometriosis group. CONCLUSIONS: Quantification of ovarian stromal blood flow by 3D power Doppler ultrasound in women with endometriosis may provide an important prognostic indicator in those undergoing IVF.
Subject(s)
Fertilization in Vitro , Ovary/blood supply , Adult , Blood Flow Velocity/physiology , Endometriosis/diagnostic imaging , Endometriosis/physiopathology , Endometriosis/surgery , Female , Humans , Imaging, Three-Dimensional , Infertility, Female/physiopathology , Infertility, Female/therapy , Leptin/blood , Retrospective Studies , Treatment Outcome , Ultrasonography, Doppler, Color/methodsABSTRACT
This study investigated the effect of pressure on the retention behavior of a model protein, lysozyme, on octadecylsilica (C18) stationary phase under various equilibrium conditions. It is demonstrated that the retention time of the lysozyme was increased by as much as two to three times as the absolute pressure on the viewing window was increased from 23 to 318 bar. This pressure-induced retention was likely to be reversible and the corresponding volume change (deltaV = Vsta - Vmob) was found to be on the order of minus tens to hundreds of mL/mol. Moreover, the pressure-induced retention was also observed for a homologous series of hydrophobic poly-L-phenylalanine, which do not have the secondary structure, and the volume change was determined to be around minus 10 mL/mol per phenylalanine. Perturbations in solute ionization and conformational change are predicted to have a minor impact under the investigated conditions. It is believed that the pressure-induced shift of the equilibria regarding hydrophobic ad-desorption is the major cause of the observed increase of protein retention. About ten phenylalanine-equivalent residues on the lysozyme surface were involved in the hydrophobic association with the chromatographic ligands.
