Self-Assembled Origami Neural Probes for Scalable, Multifunctional, Three-Dimensional Neural Interface.

Flexible intracortical neural probes have drawn attention for their enhanced longevity in high-resolution neural recordings due to reduced tissue reaction. However, the conventional monolithic fabrication approach has met significant challenges in: (i) scaling the number of recording sites for electrophysiology; (ii) integrating of other physiological sensing and modulation; and (iii) configuring into three-dimensional (3D) shapes for multi-sided electrode arrays. We report an innovative self-assembly technology that allows for implementing flexible origami neural probes as an effective alternative to overcome these challenges. By using magnetic-field-assisted hybrid self-assembly, multiple probes with various modalities can be stacked on top of each other with precise alignment. Using this approach, we demonstrated a multifunctional device with scalable high-density recording sites, dopamine sensors and a temperature sensor integrated on a single flexible probe. Simultaneous large-scale, high-spatial-resolution electrophysiology was demonstrated along with local temperature sensing and dopamine concentration monitoring. A high-density 3D origami probe was assembled by wrapping planar probes around a thin fiber in a diameter of 80∼105 µm using optimal foldable design and capillary force. Directional optogenetic modulation could be achieved with illumination from the neuron-sized micro-LEDs (µLEDs) integrated on the surface of 3D origami probes. We could identify angular heterogeneous single-unit signals and neural connectivity 360° surrounding the probe. The probe longevity was validated by chronic recordings of 64-channel stacked probes in behaving mice for up to 140 days. With the modular, customizable assembly technologies presented, we demonstrated a novel and highly flexible solution to accommodate multifunctional integration, channel scaling, and 3D array configuration.

Two-Dimensional Self-Assembly of Boric Acid-Functionalized Graphene Quantum Dots: Tunable and Superior Optical Properties for Efficient Eco-Friendly Luminescent Solar Concentrators.

Carbon-based nanomaterials hold promise for eco-friendly alternatives to heavy-metal-containing quantum dots (QDs) in optoelectronic applications. Here, boric acid-functionalized graphene quantum dots (B-GQDs) were prepared using bottom-up molecular fusion based on nitrated pyrenes and boric acid. Such B-GQDs with crystalline graphitic structures and hydrogen-bonding functionalities would be suitable model systems for unraveling the photoluminescence (PL) mechanism, while serving as versatile building blocks for supramolecular self-assembly. Unlike conventional GQDs with multiple emissive states, the B-GQDs exhibited excitation-wavelength-independent, vibronic-coupled excitonic emission. Interestingly, their PL spectra can be tuned without largely sacrificing the quantum yield (QY) due to two-dimensional self-assembly. In addition, such B-GQDs in a polystyrene matrix possessed an ultrahigh QY (∼90%) and large exciton binding energy (∼300 meV). Benefiting from broadband absorption, ultrahigh QY, and long-wavelength emission, efficient laminated luminescent solar concentrators (100 × 100 × 6.3 mm3) were fabricated, yielding a high power conversion efficiency (1.4%).