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1.
Int J Mol Sci ; 16(3): 6140-52, 2015 Mar 17.
Article in English | MEDLINE | ID: mdl-25789502

ABSTRACT

Five new polyoxygenated cembranoids, named (+)-1,15-epoxy-2-methoxy-12-methoxycarbonyl-11E-sarcophytoxide (1), (+)-2-epi-12-methoxycarbonyl-11E-sarcophine (2), 3,4-epoxyehrenberoxide A (3), ehrenbergol D (4) and ehrenbergol E (5), were obtained from the soft coral Sarcophyton ehrenbergi. The structures of 1-5 were established on the basis of comprehensive NMR and HR-ESI-MS analyses and by comparison with reported data in the literature. Compounds 4 and 5 showed moderate cytotoxicity against P-388 (mouse lymphocytic leukemia) cancer cell line with EC50 values of 2.0 and 3.0 µM, respectively. Compound 2 exhibited slight antiviral activity against HCMV (human cytomegalovirus) with IC50 values of 25.0 µg/mL.


Subject(s)
Anthozoa/chemistry , Diterpenes/chemistry , Oxygen/chemistry , Animals , Anthozoa/metabolism , Antineoplastic Agents/chemistry , Antineoplastic Agents/pharmacology , Antiviral Agents/chemistry , Antiviral Agents/pharmacology , Apoptosis/drug effects , Cell Line, Tumor , Cytomegalovirus/drug effects , Diterpenes/pharmacology , HT29 Cells , Humans , Magnetic Resonance Spectroscopy , Mice , Molecular Conformation , Spectrometry, Mass, Electrospray Ionization
2.
Mar Drugs ; 11(11): 4318-27, 2013 Oct 30.
Article in English | MEDLINE | ID: mdl-24177676

ABSTRACT

Continuing chemical investigation on the acetone extracts of the soft coral Sarcophyton ehrenbergi collected off the coast of San-hsian-tai, Taitong County, Taiwan led to the isolation of two new diterpenoids, ehrenbergol C and acetyl ehrenberoxide B (1 and 2). The structures of these isolated metabolites were elucidated through extensive spectroscopic analyses. Moreover, in vitro tests show that compounds 1 and 2 displayed antiviral activity towards human cytomegalovirus, with EC50 of 20 and 8.0 µg/mL, respectively.


Subject(s)
Anthozoa/chemistry , Diterpenes/chemistry , Animals , Antiviral Agents/chemistry , Antiviral Agents/pharmacology , Cytomegalovirus/drug effects , Diterpenes/pharmacology , Drug Screening Assays, Antitumor/methods , Spectrum Analysis/methods , Taiwan
3.
Mar Drugs ; 10(7): 1433-1444, 2012 Jul.
Article in English | MEDLINE | ID: mdl-22851917

ABSTRACT

In order to search for new bioactive substances from marine organisms, we have investigated the acetone extracts of the soft coral Sarcophyton ehrenbergi collected at San-Hsian-Tai, Taitong County, Taiwan. Chromatographic fractionation of the extracts of the octocoral S. ehrenbergi led to the isolation of three new cembranoids, (+)-12-ethoxycarbonyl-11Z-sarcophine (1), ehrenbergol A and B (2 and 3). The structures of these isolated metabolites were elucidated through extensive spectroscopic analyses. Moreover, metabolites 1-3 were evaluated in vitro for their cytotoxicity towards selected cancer cell lines and antiviral activity against human cytomegalovirus (HCMV).


Subject(s)
Anthozoa/chemistry , Diterpenes/isolation & purification , Animals , Cytomegalovirus/drug effects , Diterpenes/chemistry , Diterpenes/pharmacology , Humans , Magnetic Resonance Spectroscopy , Mice , Taiwan
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