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Neurosci Lett ; 314(1-2): 49-52, 2001 Nov 13.
Article in English | MEDLINE | ID: mdl-11698144

ABSTRACT

We investigated whether single injection of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) (20 mg/kg) will alter the expression of pro-apoptotic genes, namely, the c-fos, c-jun, and bax, in the striatum, cortex, and cerebellum of adult male C57BL/6 mice using reverse transcription-polymerase chain reaction assay. Injection of MPTP induced a transient decrease in the content of tyrosine hydroxylase estimated by the immunoreactivity in the striatum, which completely recovered 14 day after injection. A rapid but transient up-regulation of c-fos and c-jun genes occurred an hour after MPTP-injection, and a delayed but persistent up-regulation of bax gene expression occurred 3 day after injection. The up-regulation of these genes was present in all the examined brain regions. This result suggests that MPTP, at a low dose causing transient degeneration in the striatum, is capable of triggering two genetic pathways related to the generation of apoptosis in both dopaminergic and non-dopaminergic systems in the mouse brain.


Subject(s)
Apoptosis/drug effects , Brain/drug effects , Parkinsonian Disorders/genetics , Proto-Oncogene Proteins c-bcl-2 , Proto-Oncogene Proteins c-fos/drug effects , Proto-Oncogene Proteins c-jun/drug effects , Proto-Oncogene Proteins/drug effects , Up-Regulation/drug effects , 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/pharmacology , Animals , Apoptosis/physiology , Brain/metabolism , Brain/physiopathology , Cerebellum/drug effects , Cerebellum/metabolism , Cerebellum/physiopathology , Cerebral Cortex/drug effects , Cerebral Cortex/metabolism , Cerebral Cortex/physiopathology , Dopamine/metabolism , Dose-Response Relationship, Drug , Drug Administration Schedule , Gene Expression Regulation/drug effects , Gene Expression Regulation/physiology , Male , Mice , Mice, Inbred C57BL , Neostriatum/drug effects , Neostriatum/metabolism , Neostriatum/physiopathology , Parkinsonian Disorders/metabolism , Parkinsonian Disorders/physiopathology , Proto-Oncogene Proteins/genetics , Proto-Oncogene Proteins c-fos/genetics , Proto-Oncogene Proteins c-jun/genetics , RNA, Messenger/drug effects , RNA, Messenger/metabolism , Tyrosine 3-Monooxygenase/metabolism , Up-Regulation/genetics , bcl-2-Associated X Protein
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