Transparent scientific reporting is imperative during the pandemic.

The coronavirus pandemic has exposed not only the lack of preparation to combat the deadly disease, but also the nature of response by governments worldwide. This article analyses how some governments suppress science reporting in the Asia Pacific region during the pandemic. It also highlights how the political interference in science undermines liability and openness leading to the lack of freedom to express facts honestly.

How the Coronavirus Lockdown Impacts the Impoverished in India.

In response to the coronavirus pandemic, several countries have imposed curfews, quarantines, and lockdowns to restrict the spread of the infection among people. India had initiated a nationwide lockdown to combat the pandemic starting from the last week of March until the end of May 2020. But, the lockdown had continued subsequently in several red zones across parts of the country for few months. However, scientists have criticized the government's abrupt lockdown since it prevented people from preparing for the worst aftermath. Besides, the curfews have blocked millions of impoverished migrant workers from leaving cities to return to their homes in distant rural villages. As a result, the destitute workers have endured enormous hardship and outright discrimination desolately leading to their added physical and mental distress, pain, suffering, and death. Most of the victims of the lockdown have belonged to the economically distressed lower social classes of the Indian caste hierarchy. This article outlines their sufferings triggered by the long drawn-out lockdown episode.

Groundwater Storage Trends and Their Link to Farmer Suicides in Maharashtra State, India.

Threats posed by land degradation and desertification continue to destabilize India's agriculture productivity and food security. The enduring negative environmental consequences of the agricultural intensification that started during the 1960s have further contributed to the depletion of soil nutrients in farmlands through heavy input of chemical fertilizers and pesticides. More than half of India's population depends on farming. When crop productivity fails, the economically-depressed farmers are unfortunately pushed toward suicide. The news of farmers committing mass suicide in Maharashtra state of India has lately received world attention. Although suicide may involve various psychological, social and economic factors, access to irrigation water remains a contentious matter in the agriculture business. The groundwater (GW) data from government sources are limited and not displayed in the public domain for verification. Hence, this study used the Gravity Recovery and Climate Experiment (GRACE) satellite data to compare farmer suicide rate in Maharashtra with GW storage estimates at broad spatiotemporal scales. The results show significant correlations (r = -0.85, p < 0.005) between water storage and suicide rate when time lags of 2 years are introduced between them. Based on the new findings, this study recommends that the GW status needs to be monitored scientifically across India's suicide zone. By doing so, the worst case scenarios can be logically predicted well in advance. The government then may have the advantage to mobilize its resources on the ground to implement rapid emergency measures and farmer consultations to minimize future farmer suicide cases.

Social implications of fission in wild Formosan macaques at Mount Longevity, Taiwan.

Group fission in non-human primates has long been proposed to result from interactions between ecological and social factors. Several studies have documented possible causes for group fission, but its proximate causes and ultimate adaptive values are not yet fully understood. We have examined the existing hypotheses on fission from long-term demographic data of Formosan macaques inhabiting the lowland rainforest at Mt Longevity, Taiwan. Five cases of fission occurred in four social groups. We have recorded two types of fission: one involving the separation of a high-ranking adult male and multiple adult females, the other initiated by adult females from main groups. Five adult females immigrated and emigrated a few times between the main and branch groups (oscillation) in three fission events. Data presented in this study are consistent with the prediction that low-ranking females split from main groups when their fitness costs increase due to ecological pressure or population growth. However, their reproductive success may decrease after fission due to a high rate of intra-group competition. Nevertheless, it is beneficial for males to be involved in fission since this increases reproductive benefits by decreasing the sex ratio in small newly formed groups.

The Suicide Paradigm: Insights from Ancient Hindu Scriptures.

The world religions in general promote peace and happiness. They strongly discourage all sorts of violence in society including suicide. Religious commitments toward life-saving value are known to prevent suicide attempts since all world religions promote unity, reducing interpersonal hostilities. Therefore, understanding the basics on what religious scriptures narrate on life and death including suicide is essential. This paper highlights the seldom discussed topic on the concept and consequences of suicide portrayed in the ancient Hindu religious scriptures.

Harvesting river water through small dams promote positive environmental impact.

While deliberations relating to negative consequences of large dams on the environment continue to dominate world attention, positive benefits provided by small dams, also known as check dams, go unobserved. Besides, little is known about the potential of check dams in mitigating global warming impacts due to less data availability. Small dams are usually commissioned to private contractors who do not have clear mandate from their employers to post their work online for public scrutiny. As a result, statistics on the design, cost, and materials used to build check dams are not available in public domain. However, this review paper presents data for the first time on the often ignored potential of check dams mitigating climate-induced hydrological threats. We hope that the scientific analysis presented in this paper will promote further research on check dams worldwide to better comprehend their eco-friendly significance serving society.

Drug Metabolizing Enzymes in Type II Diabetes and their Pharmacogenetics During Therapy of Anti-Diabetes Drugs.

The type 2 diabetes or T2D mellitus has turn into an epidemic throughout the globe in recent years. Various forms of treatment modalities have been available for patients with T2D with some major classes of approved drugs that include Sulfonylureas, Meglitinides, Biguanides, Thiazolidinedione, Alpha-glucosidase inhibitors, GLP-1 analogs, DPP-4 Inhibitors, and SGLT2 inhibitors. This review focuses on the drug metabolizing enzymes (DME), gene polymorphisms, and inter-individual variability in therapeutics including adverse reaction effects involving Phase-I DME and Phase-II in general. This review also covers some key anti-diabetic drugs with respect to their pharcogenomics.

Can the chemotherapeutic agents perform anticancer activity through miRNA expression regulation? Proposing a new hypothesis [corrected].

In the recent advancement of cancer therapy, mortality of the immortal cancer cells begins to decline, and it shows great promise for the chemotherapy regimen supported by targeted therapy. In this post-genomic era boosted by the discovery of microRNA (miRNA), it has been understood that miRNA regulates gene expression at the post-transcriptional level. On the other hand, some studies have also indicated that miRNA expression level has changed during the treatment of chemotherapy. Data based on various previous studies, we propose that the chemotherapeutic agents modulate miRNA expression that might perform anticancerous activities through cellular changes such as DNA repair, cell cycle arrest, or apoptosis.

Non-Maternal Infant Handling in Wild Formosan Macaques of Mount Longevity, Taiwan.

In this paper, we present quantitative data on how the social network and sex of infants influence allomothering behaviour among wild Formosan macaques, Macaca cyclopis. Using long-term field data collected from the Mount Longevity study site in Kaohsiung (Taiwan), we have tested relevant hypotheses incorporating data on age, rank and reproductive state of infant handlers, and the relationship between handlers and infants. The results support 2 major hypotheses, i.e. those of reciprocity and alliance formation. Nevertheless, neither could account for the observed occurrences of unrelated infant handling by dominant females.

Living on the Societal Edge: India's Transgender Realities.

The transgendered people have played an important role in ancient Indian culture over millennia. They were portrayed in famous Hindu religious scriptures such as Ramayana and Mahabharata. They were given imperative roles in the royal courtyards of Mughal emperors. Their downfall came only at the onset of British rule during the eighteenth century when they were blacklisted and treated as criminal elements in society. Only in 2014, India's Supreme Court has made a landmark ruling by declaring that the transgendered people must have access to equal opportunity in society. In spite of this legal recognition, transgenders at large have been forced to live on the fringes of the contemporary Indian society. This article explores their past glories, present struggles and future ambitions in the world's largest democracy.

Understanding the molecular dynamics of type-2 diabetes drug target DPP-4 and its interaction with Sitagliptin and inhibitor Diprotin-A.

The occurrence of type 2 diabetes (T2D) accounts for 90-95 % of all diabetes. Intestine hormone glucagon-like peptide-1 (GLP-1) has an antidiabetic role that enhances insulin secretion and pancreatic ß-cell proliferation. GLP-1 is degraded by the enzyme dipeptidyl peptidase-4 (DPP-4) rapidly. Hence, the DPP-4 inhibition has been preferred not only for the treatment but also as a major drug target. Sitagliptin and Diprotin-A are antihyperglycemic agents for the treatment of T2D. However, little is known on the molecular dynamics of DPP-4 and the interaction properties with its ligands, namely Sitagliptin and Diprotin-A. This study has used the latest bioinformatic tools to understand the molecular dynamics and its interaction properties of DPP-4. This study has explored the number of α helices, ß strands, ß hairpins, Ψ loop, ß bulges, ß turns, and ϒ turns and they were 19, 46, 25, 1, 14, 70, and 4, respectively. The highest number of H-bonds was recorded in α helix of domain-1, and the lowest number H-bonds were noted in α helix of domain-2. During interaction between residues, in A- and B-chain, 47 and 48 residues are involved for interaction, and interaction interface area was more in A-Chain (2176 Å(2)). From DPP-4 and Sitagliptin interaction, three residues in active sites such as Try226, Glu205, and Glu206 were involved in three H-bond formation, while 10 other amino acids (Try547, Try667, Asn710, Val711, His740, Ser630, Ser209, Arg358, Phe357, and Val207) were involved in hydrophobic interactions. In this review, we have shown the importance of bioinformatics as an excellent tool for a rapid method to assess the molecular dynamics and its interaction properties of DPP-4. Our predictions highlighted in this review will help researchers to understand the interaction properties and recognition of interactive sites to design more DPP-4 inhibitors for the treatment of T2D and drug discovery.

Compression as a universal principle of animal behavior.

A key aim in biology and psychology is to identify fundamental principles underpinning the behavior of animals, including humans. Analyses of human language and the behavior of a range of non-human animal species have provided evidence for a common pattern underlying diverse behavioral phenomena: Words follow Zipf's law of brevity (the tendency of more frequently used words to be shorter), and conformity to this general pattern has been seen in the behavior of a number of other animals. It has been argued that the presence of this law is a sign of efficient coding in the information theoretic sense. However, no strong direct connection has been demonstrated between the law and compression, the information theoretic principle of minimizing the expected length of a code. Here, we show that minimizing the expected code length implies that the length of a word cannot increase as its frequency increases. Furthermore, we show that the mean code length or duration is significantly small in human language, and also in the behavior of other species in all cases where agreement with the law of brevity has been found. We argue that compression is a general principle of animal behavior that reflects selection for efficiency of coding.

Can computational biology improve the phylogenetic analysis of insulin?

Using computational biology, we have depicted the insulin phylogenetics. We have also analyzed the sequence alignment and sequence logos formation for both the insulin chain A and B for three groups namely, the mammalian group, vertebrates group and fish group. We have also analyzed cladograms of insulin for the mammalian group. In accordance with that path lengths, matrix for distance analysis, matching representation of nodes of the cladogram and dissimilarity between two nodes have been performed for both of the A and B chains of the mammalian group. Our results show that 12 amino acid residues (GlyA1, IleA2, ValA3, TyrA19, CysA20, AsnA21, LeuB6, GlyB8, LeuB11, ValB12, GlyB23 and PheB24) are highly conserved for all groups and among them some (GlyA1, IleA2, ValA3);(TyrA19, CysA20, AsnA21) are continuous. This study shows a rapid method to calculate the amino acid sequences in terms of evolutionary conservation rates as well as molecular phylogenetics.

Exploring the evolutionary relationship of insulin receptor substrate family using computational biology.

Insulin receptor substrate (IRS) harbors proteins such as IRS1, IRS2, IRS3, IRS4, IRS5 and IRS6. These key proteins act as vital downstream regulators in the insulin signaling pathway. However, little is known about the evolutionary relationship among the IRS family members. This study explores the potential to depict the evolutionary relationship among the IRS family using bioinformatics, algorithm analysis and mathematical models.

Landscape mapping of functional proteins in insulin signal transduction and insulin resistance: a network-based protein-protein interaction analysis.

The type 2 diabetes has increased rapidly in recent years throughout the world. The insulin signal transduction mechanism gets disrupted sometimes and it's known as insulin-resistance. It is one of the primary causes associated with type-2 diabetes. The signaling mechanisms involved several proteins that include 7 major functional proteins such as INS, INSR, IRS1, IRS2, PIK3CA, Akt2, and GLUT4. Using these 7 principal proteins, multiple sequences alignment has been created. The scores between sequences also have been developed. We have constructed a phylogenetic tree and modified it with node and distance. Besides, we have generated sequence logos and ultimately developed the protein-protein interaction network. The small insulin signal transduction protein arrangement shows complex network between the functional proteins.