[The analysis and discussion of clinical features and treatment of tumor like Sjögren's syndrome in 46 cases].

OBJECTIVE: Manifestations and treatment of tumor-like Sjögren's syndrome(SS) is varying, it is difficulty to differentiate it from other diseases. The purpose of this paper was to identify the peculiarity of the manifestations and treatment of tumor like SS. METHODS: The data of 46 cases suffering from tumor like SS had been analyzed retrospectively and discussed with published articles about its clinical features and treatment. RESULTS: There were one or more than one masses in salivary gland, general manifestations were found in 46 cases, dry mouth 41%,dry eye 23%, autoantibody 17%. The result of treatment showed recurrence site of operation group was out of primary region, recurrence rate was 20%. Effective rate of drug group was about 81%,however, recurrence rate was up to 38%. Malignant change occurred in three cases. CONCLUSION: The local feature of tumor like SS is mass in salivary gland, general manifestations are accompanied in some patients. It presents chronic benign process, malignant change may occur in a few patients. Combined therapy should be taken reasonably, local with general, drug with operation. The diagnosis should be identified before treatment, drug therapy is used at first, and operation is adopted after failure of drug treatment.

[Preliminary study on diagnosis of tumor like Sjögren's syndrome].

OBJECTIVE: To explore the clinical features and diagnosis of tumor like Sjögren's Syndrome. METHODS: 22 cases with tumor-like Sjögren's Syndrome of parotid gland, 50 cases with pleomorphic adenoma of parotid gland and 25 cases with adenolymphoma of parotid gland were studied retrospectively. RESULTS: Statistical analysis showed that tumor like Sjögren's Syndrome is predominantly in middle-aged women (40-59y) with a woman to man ratio of 6.33:1. Patients commonly present with salivary gland swelling repeatedly,varying in size,response effectively with antibiotics, accompanying dry mouth,dry eyes and aching joints. The mass probably displays medium texture and smooth appearance. The discriminant functions with tumor like Sjögren's Syndrome, pleomorphic adenoma and adenolymphoma were also established. CONCLUSION: The discriminate functions provide a simple and practical method to diagnose tumor-like Sjögren's Syndrome.

[Detection of clinical diagnosis and different symptoms of Sjogren's syndrome by traditional chinese medicine (TCM)]

OBJECTIVE:To search for the appropriate diagnostic criteria of SS and confirm the differentiation of SS.METHODS:The European di agnostic criteria has been used in clinic work for about two years,and differentiated the symptoms of SS by TCM. The specialty and relationship between them was made an inquiry.RESULTS:The European criteria set for SS offers the clinic work a practical method to correctly classify the patients suspected of having this disorder. It refers to the signs and symptoms caused by the insufficiency of spleen-qi with deficiency of liver-yin and kidney-yin.CONCLUSION:It has been further proved for easy to make up the diagnostic of SS and its treatment using traditional chinese medicine.

[Experimental research on animal model and treatment of Sjogren's syndrome by traditional chinese medicine (TCM)]

OBJECTIVE:To confirm the function of SS Syrup used in our department. METHODS: Under the basis of TCM and differentiation symptoms of SS,the animal model was established and applied to test the function of SS syrup.There are three indices to be observed,weight change,volume of drinking water daily,cAMP change. RESULTS: The three observed indices of dificiency symptom model had been rectified by SS syrup. CONCLUSION: SS syrup has two main functions:(1)reinforcing of the spleen and tonifying qi;(2)nourishing liver-yin and kidney-yin as well as removing pathogentic heat and fire.

[Primary research of development of a mouse model for non-bacterial sialoadenitis]

OBJECTIVE: To develope a mouse model for non-bacterial sialoadenitis similar to SS.The model of organ-specific to the submandibular gland of mouse has developed for this study. METHODS: Several of the mouse strains were used to the development of non-bacterial sialoadenitis.The injection of syngeneic salivary gland tissue with CFA induced inflammation in submandibular gland in mice.Not all mice had a predictable response. RESULTS: C(57) mice (500microg/ml and 750microg/ml group )appear histologically to be more prove to develop sialoadenitis. CONCLUSION: An animal model of non-bacterial sialoadenitis had been set up,the non-bacterial sialoadentitis may be similar to the autoimmune process in human SS.

[Clinic analysis of 46 cases of Sjogren's syndrome.].

Sjogren's syndrome (SS) is more common in female.Being lack of dryness in mouth and eyes,parotid gland swelling in early stage of majority patients,SS would be misdiagnosed.In a few cases,it may prominently manifest damage only in some system,such as liver and spleen enlargement,hyperglobulinemia etc,so that it would interfere the diagnosis.Examining function of salivary and lacrimal gland or sialography as well as lower lip biopsy is necessary for the diagnosis.In this article,we discussed primarily about 1.the diagnosis of the primary form of SS; 2.the diagnosis of systemic damages in SS; 3.the diagnosis of SS complicating other autoimmune disease.