Urban green total factor energy efficiency and its decomposition under a multidimensional heterogeneity framework: a case study of the Yellow River Basin, China.

Assessing and monitoring the green total factor energy efficiency (GTFEE) of cities while considering technology heterogeneity is crucial for the development of energy-conservation and emission-reduction policies. Considering that the heterogeneity of production technologies encompasses several dimensions, this paper proposes a 3E3S (Economy-Environment-Energy-Society-Science-Space) heterogeneity framework and integrates it with the improved meta-frontier global SBM-undesirable to analyze GTFEE and its decomposition. Empirical analysis of cities in the Yellow River Basin of China (YRBC) highlights the following: (1) The 3E3S heterogeneity framework facilitates the classification of all cities into three distinct groups, a finding that contrasts significantly with previous outcomes documented in the literature that relied solely on criteria such as geographic location. (2) The three groups identified under the meta-frontier exhibit substantial energy-saving potentials of 24.49%, 35.17%, and 52.46%, respectively. Additionally, there are spatiotemporal variations in GTFEE, with cities located in the central part of YRBC, particularly those in Shanxi province, demonstrating poor GTFEE performance. (3) The decomposition analysis of GTFEE indicates that technological progress plays a pivotal role in enhancing GTFEE on the whole, albeit with varying approaches for improving GTFEE depending on individual cities.

Exploring gut microbiota's role in rheumatic valve disease: insights from a Mendelian randomization study and mediation analysis.

Background: Investigating the relationship between gut microbiota and Rheumatic Valve Disease (RVD) is crucial for understanding the disease's etiology and developing effective interventions. Our study adopts a novel approach to examine the potential causal connections between these factors. Methods: Utilizing a two-sample Mendelian Randomization (MR) framework, we incorporated a multi-variable MR (MVMR) strategy to assess the mediatory mechanisms involved. This approach involved analyzing data from the MiBioGen consortium for gut microbiota and the FinnGen for RVD, among other sources. Instrumental variables (IVs) were carefully selected based on rigorous MR principles, and statistical analysis was conducted using bidirectional two-sample MR, such as inverse variance-weighted (IVW), weighted median, MR-Egger regression and MR Steiger Test methods. The MR-PRESSO strategy was employed for outlier detection, and MVMR was used to untangle the complex relationships between multiple microbiota and RVD. Results: Our analysis highlighted several gut microbiota classes and families with potential protective effects against RVD, including Lentisphaerae, Alphaproteobacteria, and Streptococcaceae. In contrast, certain genera, such as Eubacterium eligens and Odoribacter, were identified as potential risk factors. The MVMR analysis revealed significant mediation effects of various immune cell traits and biomarkers, such as CD4-CD8- T cells, CD3 on Terminally Differentiated CD8+ T cell and Pentraxin-related protein PTX, elucidating the complex pathways linking gut microbiota to RVD. Conclusion: This study underscores the intricate and potentially causal relationship between gut microbiota and RVD, mediated through a range of immune and hormonal factors. The use of MVMR in our methodological approach provides a more comprehensive understanding of these interactions, highlighting the gut microbiota's potential as therapeutic targets in RVD management. Our findings pave the way for further research to explore these complex relationships and develop targeted interventions for RVD.

Regulation Mechanism for Designing Decarbonization Pathways in the Copper Industry Toward Carbon Neutrality.

The transformation of the global power structure caused by the carbon neutrality goal will promote copper consumption. It is crucial to explore the decarbonization pathways of the copper industry to help fulfill greenhouse gas (GHG) emission reduction targets. This study utilized material flow analysis and life cycle assessment methods to investigate 12 different subscenarios based on international trade, circular economy, technology evolution, and environmental market factors. Policy combination scenario is employed to reveal the mechanism of decarbonization. The results show that refined copper consumption in China is expected to increase by 62.3% in 2060 compared to 2020. The GHG emissions of China's copper industry will reach 9.1 million tonnes (Mt) CO2e in 2060, technology evolution and environmental market are crucial for realizing carbon neutrality goal of this industry, accounting for 26.4 and 47.2% of emissions reductions, respectively, between 2020 and 2060. International trade and circular economy play important roles in the high-quality carbon peaking stage; however, imported copper and domestic secondary copper will constitute the basic supply of copper resources in China in the long run, and the comparative advantages of them will gradually weaken. Policy combination scenario can achieve the incentive synergy effect, with GHG reduced to 0.5 Mt CO2e in 2060. The enhanced application of policies such as material substitution and carbon emission trading will further promote industry to achieve net-zero GHG emission. We suggest regulating the industry's structure based on the international systemic circulation pattern and accelerating the construction of a green circular chain in the short term to achieve sustainable copper supply and high-quality carbon peaking. Promoting a high-quality technology development strategy and enhancing the environmental markets are recommended in the long term to achieve carbon neutrality.

Ecological performance assessment of ecologically fragile areas: a perspective of spatiotemporal analysis.

Sustainable development in ecologically fragile areas (EFAs) has faced significant challenges in recent years, but the traditional analytical approaches fail to provide an ideal assessment for ecological performance due to spatiotemporal variability in EFAs. This paper evaluates the ecological performance of EFAs based on a modified ecological footprint model, and ecological footprint intensity (EFI) is considered an essential indicator to measure ecological performance, especially for EFAs. Empirically, taking the Π-shaped Curve Area in the Yellow River basin of China as the study area, the spatiotemporal heterogeneity of EFI of 17 cities in the area is analyzed. Then, the extended STIRPAT and geographically and temporally weighted regression (GTWR) models are employed to explore the spatiotemporal heterogeneity of the factors driving EFI. The results show that from 2006 to 2019, the overall level of EFI in the area has decreased; EFI of the area offers a significant spatial agglomeration effect; results of the GTWR model suggest that factors driving EFI have spatiotemporal heterogeneity; the impact of population size, openness, marketization, technology, industrial structure rationalization, and information communication level on EFI was two-sided, while that of affluence, government scale, environmental regulation, and industrial structure advancement show inhibitory impact with the intensity of inhibition varying across periods and cities.

How do information and communication technology and urbanization affect carbon emissions? Evidence from 42 selected "Belt and Road Initiative" countries.

Reducing carbon emissions is key to achieving the 13th UN sustainable development goals. With the acceleration of informatization and urbanization in the "Belt and Road Initiative" (BRI) countries, it is necessary to explore the impact of ICT and urbanization on carbon emissions in the BRI countries. This paper uses the Driscoll-Kraay panel regression method, multi-chain mediation effect model, and panel moment quantile regression method to study the influence channel and heterogeneous impact of ICT, urbanization, and their interaction on carbon emissions in 42 selected BRI countries. The main empirical results reveal the inhibition of ICT and the promotion of urbanization on carbon emissions. Moreover, the integrated development of ICT and urbanization contributes to reducing carbon emissions. Industrial structure upgrading and energy intensity are found to be the channels through which ICT, urbanization, and their interactions affect carbon emissions. In addition, the impact of ICT, urbanization, and their interaction on carbon emissions varies with different measurement indicators and quantiles. Therefore, it is suggested that BRI countries should formulate appropriate ICT development policies according to their conditions, strengthen ICT application, and especially promote the integrated development of ICT and urbanization, to achieve sustainable urban development.

From low carbon to carbon neutrality: A bibliometric analysis of the status, evolution and development trend.

With global climate change becoming increasingly serious, carbon neutrality, a key strategy to mitigate climate change, has attracted widespread attention. However, due to the multidisciplinary and complexity of carbon neutrality studies, as well as the diversification of research content, a comprehensive review and systematic synthesis of which is quite limited. In this paper, a bibliometric analysis on the topic of carbon neutrality is conducted to reveal the research progress from a quantitative and visual perspective and describe the evolution of research hotspots. The results show that carbon neutrality research is abundant at both the macro and micro levels. Low carbon development is the premise of carbon neutrality, and emission reduction and carbon sinks are the basis of carbon neutrality. The degree of research varies significantly in different countries, with China dominating in the number of publications, followed by the USA and the UK. The realization of carbon neutrality cannot be fully achieved by one single perspective and requires a comprehensive and systematic analysis of technology, economy, and society. Carbon neutrality is a technology-driven process guided by policy. Economically, carbon taxes and carbon markets are two important market mechanisms for reducing carbon emissions. Technically, researches of negative carbon technologies and renewable energy are growing rapidly. Carbon market, carbon negative technology, circular economy, and green energy will become the focus of future research. This paper helps scholars to understand the overall state of carbon neutrality research and provides a historical reference for future research.

The application of resilience theory in urban development: a literature review.

In the complex context of urbanization and climate change, how to improve the resilience of cities to deal with various uncertain and unpredictable threats is a new topic with both theoretical and practical challenges. In this paper, the researches on urban resilience are summarized using the bibliometric analysis combined with the visualization analysis. We provide a systematic and objective review of resilience applied to urban development focusing on its conceptual frameworks, research tendencies, and assessment methods. The analysis results demonstrate that an increasing attention has been given to urban resilience, especially in the field of climate change. The degree of research varies significantly in different countries, with the USA dominating in the number of publications, followed by the UK and China. Scholars' attention to urban resilience in different periods is closely related to the development background and disasters experienced by their countries, but there are also some commonalities. Meanwhile, the multi-dimensional research on urban resilience has been recognized by many scholars. Quantitative assessment tools such as simulation model and optimization model have been widely used to assess the level of urban resilience. Based on this, we put forward the future research trends in this field and provide a potential guide for future application of urban resilience.

Analysis of Cardiac Adverse Reactions Caused by Different Doses of Adriamycin Chemotherapy in Patients with Breast Cancer.

PURPOSE: This paper is aimed at studying the adverse reactions of breast cancer patients after chemotherapy with different doses of adriamycin. METHODS: 122 breast cancer patients undergoing mastectomy in the Haining Central Hospital from June 2018 to June 2020 were selected as the research objects. Patients were divided into control group and study group according to the different dose of adriamycin given to patients during chemotherapy. Patients in the control group received intravenous drip of adriamycin at 50 mg/m2. Patients in the study group were given intravenous drip at 75 mg/m2. Patients in both the groups started intravenous drip of cyclophosphamide 500 mg/m2 on the first day of chemotherapy, and chemotherapy for 21 days was a cycle. A total of 6 cycles were carried out. Abnormal electrocardiograph (ECG) is compared between the two groups. Myocardial enzyme and oxidative stress indicators were tested, and Doppler ultrasound examination was conducted. RESULTS: After chemotherapy, the abnormal rate of ECG in the study group was 56.46%, which was significantly higher than that in the control group (46.67%). After chemotherapy, the indexes of myocardial enzymes and oxidative stress increased, while superoxide dismutase (SOD) decreased significantly, and the differences were statistically significant. At the end of chemotherapy, the differences of serum myocardial enzymes and oxidative stress indexes in the study group were higher than those in the control group. After chemotherapy, there was no significant difference between left ventricular ejection fraction (LVEF) and Sa in the study group and the control group, but Ea in the study group was higher than that in the control group and E/Ea was lower than that in the control group. CONCLUSION: High-dose adriamycin chemotherapy is more likely to cause accumulation of cardiotoxicity, resulting in decreased cardiac function and cardiac injury in breast cancer patients.