Subject(s)
Mycoplasma , Pleural Effusion/veterinary , Pleuropneumonia/veterinary , Animals , Cat Diseases/diagnostic imaging , Cats , Color , UltrasonographySubject(s)
Blastocystis Infections/diagnosis , Blastocystis hominis/isolation & purification , Dysentery, Amebic/diagnosis , Entamoeba histolytica/isolation & purification , Liver Abscess, Amebic/diagnosis , Animals , Antiprotozoal Agents/therapeutic use , Blastocystis Infections/drug therapy , Dysentery, Amebic/drug therapy , Humans , Liver Abscess, Amebic/drug therapy , Male , Metronidazole/therapeutic use , Middle Aged , Treatment OutcomeABSTRACT
Cervical cancer is common among women all over the world. Although infection with high-risk types of human papillomavirus (HPV) has been identified as the primary cause of cervical cancer, only some of those infected go on to develop cervical cancer. Obviously, the progression from HPV infection to cancer involves other environmental and host factors. Recent population-based twin and family studies have demonstrated the importance of the hereditary component of cervical cancer, associated with genetic susceptibility. Consequently, single-nucleotide polymorphism (SNP) markers and microsatellites should be considered genetic factors for determining what combinations of genetic factors are involved in precancerous changes to cervical cancer. This study employs a Bayesian network and four different decision tree algorithms, and compares the performance of these learning algorithms. The results of this study raise the possibility of investigations that could identify combinations of genetic factors, such as SNPs and microsatellites, that influence the risk associated with common complex multifactorial diseases, such as cervical cancer.
Subject(s)
Algorithms , Diagnosis, Computer-Assisted/methods , Gene Expression Profiling/methods , Genetic Predisposition to Disease/genetics , Genetic Testing/methods , Risk Assessment/methods , Uterine Cervical Neoplasms/diagnosis , Uterine Cervical Neoplasms/genetics , Bayes Theorem , Case-Control Studies , Female , Humans , Internet , Microsatellite Repeats/genetics , Phylogeny , Polymorphism, Single Nucleotide/genetics , Reproducibility of Results , Retrospective Studies , Sensitivity and Specificity , Uterine Cervical Neoplasms/classificationABSTRACT
Multiple myeloma associated with extramedullary plasmacytoma at initial presentation is rare. We describe a 45-year-old female patient with an initial presentation of low back pain and right side L5, S1 radiculopathy. There was no evidence of vertebral involvement but an epidural tumor was found later during neurosurgical intervention. The final diagnosis was immunoglobulin G, kappa multiple myeloma complicated with spinal root compression by an extramedullary plasmacytoma. No osteolytic lesion was noted over the length of the spine. Pathology revealed high-grade plasmablastic myeloma. During the clinical course, the patient was refractory to induction chemotherapy, and there was progressive deterioration of renal function. Urinary tract infection by Morganella morganii and pulmonary infection of unknown cause developed 5 months later, and the patient died.
